Effect of oxygen content in seed layer on microstructure and optoelectronic properties of NB-doped and undoped anatase TIO2 thin films

by Priyanka RawatM.Tech

An End-2-End tunnel header compression solution for nested mobile networks

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DEVELOPMENT AND EVALUATION OF FREEZING RESISTANT INTRAVENOUS FLUID

Objectives: Hemorrhagic or hypovolemic shocks accounts for a large portion of civilian and military trauma deaths due to life-threatening blood loss which requires intravenous fluid infusion to prevent essential deficiencies of fluids. However, at low temperature (-150C) fluid bottles freeze out and can not be used in emergency. In view of that, objective of the present work is to develop a freezing resistant intravenous formulation (FRIV) and its in vivo safety and efficacy evaluation. Methods: FRIV formulations were developed using standardized ringer lactate (RL) formulation protocol, in which varying concentrations of ethanol and glycerol were added to induce desired physiochemical properties. Efficacy of FRIV was evaluated in terms of survival percentage of hemorrhagic animal models (Swiss albino strain mice). Acute toxicity studies were carried out through an infusion at dose levels (0, 20 and 40 ml/Kg b. wt.). Results: In vitro data showed that optimized FRIV (F-10) takes more time (360 ± 21 min) for freezing and less time in thawing (50 ± 4.50 min) in comparison to control which takes (110 ± 15 min) in freezing and (80 ± 7.25 min) in thawing. Formulations were found to be stable and sterile up to six months. In vivo efficacy data showed ≥ 75% survival in animals infused with FRIV as compared to control group in hemorrhagic animal models and no treatment related toxic effects of optimized formulation in terms of hematological, serum biochemistry and histopathological analysis. Conclusion: Pre-clinical safety and efficacy data of the present study indicated that developed FRIV formulation could be used for fluid recovery during the hemorrhagic shocks conditions in the combat scenario

Combinatorial Effect of Fertigation Rate and Scheduling on Tomato Performance under Naturally Ventilated Polyhouse in Indian Humid Sub-Tropics

Protected cultivation is a resource-efficient method of crop production, however, at the same time, it is resource intensive. An optimum rate and time of fertilizer application is required in order to maximize crop yield vis-a-vis resource use efficiency. However, these aspects are scarcely studied for tomato under low- and medium-tech greenhouses in Indian humid sub-tropics. In this regard, a two-year study was conducted to assess the effect of four NPK fertilization rates (i.e., 120, 100, 80, and 60% of the recommended dose of fertilizers, RDF) and three fertigation scheduling approaches-fertigation at different stages in different proportions of NPK, along with an additional treatment, i.e., farmers' practice (soil-based application of recommended NPK) for tomatoes under a naturally ventilated polyhouse. The plant growth attributes, the tomato yield- and quality-related traits, the nutrient (NPK) accumulation by the plants, the water use efficiency (WUE), and economics were studied in response to different fertigation rates and scheduling approaches. These parameters were affected by both the rates of NPK fertilization and their time of application (scheduling) over the different growth stages. Among the different rates and time of fertigation, the recommended dose of fertilizer (100% RDF) (i.e., 300 kg N, 150 kg P2O5, and 150 kg K2O per ha and their scheduling as 15% N, 10% P2O5, and 10% K2O of RDF during 15-45 days after transplanting (P-1); 40% N, 40% P2O5, and 40% K2O of RDF during 47-76 DAT (P-2); 30% N, 40% P2O5, and 40% K2O of RDF during 77-107 DAT (P-3); and 15% N, 10% P2O5, and 10% K2O of RDF during 108-138 DAT (P-4)) was found to be the optimum for fruit yield, WUE, and economics of tomato under protected condition

Malnutrition among under Five Children in Uttarakhand

BACKGROUND: Globally more than one third of child deaths are attributable to under nutrition. Eighty percent of the world’s undernourished children live in 20 countries, with India being home to nearly 60 million children who are underweight. OBJECTIVE: This study aimed to assess malnutrition among under five children in a selected hospital of Dehradun, Uttarakhand. METHODOLOGY: A quantitative research approach was used with descriptive cross-sectional research design. Non probability convenient sampling technique was used to select 70 under five children who fulfilled the inclusion criteria. The data collection tools included Socio -demographic profile and Anthropometric assessment of the children. The data was analyzed based on objectives by using descriptive and inferential statistics. Data was analyzed using WHO anthroplus software and SPSS 21.0. RESULT: The result showed that out of 70 children 17.14% showed mild wasting, 18.57% showed moderate wasting and (21.43%) showed severe wasting. 11.43% children showed mild stunting, moderate stunting was present in 15.71% children and severe stunting was present in 27.14% children. 31.43% children were moderately underweight and 30% were severely underweight. CONCLUSION: The study concluded that majority of the children were malnourished

Genetic landscape of common epilepsies: advancing towards precision in treatment

Epilepsy, a neurological disease characterized by recurrent seizures, is highly heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types: common and rare epilepsies. Common epilepsies affecting nearly 95% people with epilepsy, comprise generalized epilepsy which encompass idiopathic generalized epilepsy like childhood absence epilepsy, juvenile myoclonic epilepsy, juvenile absence epilepsy and epilepsy with generalized tonic-clonic seizure on awakening and focal epilepsy like temporal lobe epilepsy and cryptogenic focal epilepsy. In 70% of the epilepsy cases, genetic factors are responsible either as single genetic variant in rare epilepsies or multiple genetic variants acting along with different environmental factors as in common epilepsies. Genetic testing and precision treatment have been developed for a few rare epilepsies and is lacking for common epilepsies due to their complex nature of inheritance. Precision medicine for common epilepsies require a panoramic approach that incorporates polygenic background and other non-genetic factors like microbiome, diet, age at disease onset, optimal time for treatment and other lifestyle factors which influence seizure threshold. This review aims to comprehensively present a state-of-art review of all the genes and their genetic variants that are associated with all common epilepsy subtypes. It also encompasses the basis of these genes in the epileptogenesis. Here, we discussed the current status of the common epilepsy genetics and address the clinical application so far on evidence-based markers in prognosis, diagnosis, and treatment management. In addition, we assessed the diagnostic predictability of a few genetic markers used for disease risk prediction in individuals. A combination of deeper endo-phenotyping including pharmaco-response data, electro-clinical imaging, and other clinical measurements along with genetics may be used to diagnose common epilepsies and this marks a step ahead in precision medicine in common epilepsies management

Palynostratigraphy and palynofacies of the early Eocene Gurha lignite mine, Rajasthan, India

A 105 m early Eocene section exposed in the Gurha mine in the Nagaur-Ganganagar Basin, Rajasthan, India, archiving remains of equatorial vegetation at a time of extreme global warmth and close to the onset of the India-Eurasia collision, is investigated using palynostratigraphic and palynofacies analyses. Four palynozones e.g., Palmidites plicatus Singh, Botryococcus braunii Kützing, Triangulorites bellus Kar and Ovoidites ligneolus are identified stratigraphically on the basis of abundance of these pollen taxa over others. The occurrence of taxonomically highly diverse angiosperm pollen in all the four palynozones attests to an extremely rich near-coastal tropical flora subject to frequent wildfires under a strongly seasonal precipitation regime. Palynotaxa characteristic of these palynozones are widely distributed in other early Paleogene sediments of India. Sedimentary organic matter (structured terrestrial, biodegraded, amorphous, grey amorphous, resins, charcoal/black-brown debris and algal remains) recovered from mire and lacustrine sediments are of terrestrial origin, recording fluctuations in burial anoxia and salinity. Episodes of elevated salinity are due either to seepage of marine waters and/or a periodic excess of evaporation over precipitation at times when the depositional system was closed

CD40 gene polymorphism and its expression in children with Kawasaki disease from North India: a preliminary case–control study and meta-analysis

IntroductionCD40 gene single-nucleotide polymorphisms (SNPs) have been associated with susceptibility and development of coronary artery abnormalities (CAAs) in children with Kawasaki disease (KD) in Japanese, Chinese, and Taiwanese populations. However, data on SNPs of the CD40 gene in patients with KD from the Indian subcontinent are not available. We studied the CD40 gene polymorphisms and its expression in children with KD from North India.MethodsSNPs of the CD40 gene (rs4810485, rs1535045) were studied using Sanger sequencing. CD40 expression was studied by flow cytometry. Meta-analysis was carried out to assess the role of both SNPs of the CD40 gene in KD. GRADEpro GDT software (v.3.2) was used to assess the “certainty of evidence.”ResultsForty-one patients with KD and 41 age-, sex-matched febrile controls were enrolled. However, none of the alleles and genotypes of the CD40 gene were found to be associated with KD. CD40 expression was higher in KD and in KD with CAAs compared to controls, but it failed to reach statistical significance. In a meta-analysis, the T allele of rs153045 was found to be significantly associated with KD (OR = 1.28; 95% confidence interval (: 1.09–1.50; p = 0.002). The GRADE of evidence for this outcome, however, is of “ very low certainty.”ConclusionThe present study found no association between SNPs (rs4810485 and rs153045) and susceptibility to KD. This could be a reflection of a modest sample size. CD40 expression was higher in KD and in KD with CAAs. In the meta-analysis, the T allele of rs153045 was significantly associated with KD. Our study confirms a significant genetic heterogeneity in KD among different ethnicities

ieee access special section editorial intelligent systems for the internet of things

The underlying concept of the Internet of Things (IoT) is simply to connect all devices and systems together via the Internet so that more suitable services can be provided to users. Many infrastructures, systems, and devices of the IoT have matured while some are still being developed. This is why several recent studies have claimed that IoT will dramatically change our lives. Today, we can find research topics driven by IoT technologies and can imagine that the era of smart homes and cities will be coming in the foreseeable future. The development of the IoT has reached a crossroad. One of the current research trends is to make this kind of system smarter, by using intelligent technologies to provide a much more convenient environment for humans. Among the intelligent technologies, how to handle the massive amount of data generated by the systems and devices of the IoT has been widely considered. Many other technologies, such as data mining, big data analytics, statistical and other analysis technologies, have also been used for analyzing data generated from the IoT. In addition to the analysis technologies, intelligent system technologies also provide many possibilities for the IoT because they can be used to enhance not only the performance of a system and its devices, but they can also be aware of events that have occurred