Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion

Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique case of a 62-year-old Asian female who presented with a hemorrhagic stroke suspected to be secondary to refractory hypertension from intracranial large vessel atherosclerotic flow limiting stenosis, with rapid subsequent large vessel occlusion and ischemic stroke. Questions arise such as ideal blood pressure parameters for dual management, timeliness of computed tomography angiography imaging in the emergency department for detection of large vessel occlusion during intracranial hemorrhage, and subsequent selection of treatment plan in the dual-lesion patient population

Bouncing back from bankruptcy

This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonDrawing on the concept of antifragility as a lens, this thesis explores how once bankrupted business venture owners bounce back to venture again. Examined through the prism of ‘microstoria’: the creation and sharing of contemporaneous storylines by people frequently overlooked in entrepreneurship research, the research focused on the narrative accounts of twenty UK-based entrepreneurs who have come out of bankruptcy to venture again. Data for the empirical inquiry were chiefly collected using the semi-structured interviews and publicly available documents on entrepreneurship and bankruptcy in the UK. The thesis makes contribution to knowledge in three main areas. First, it demonstrates that the once bankrupted business owners go through a series of three stages to recover from their bankruptcy entailing: determining for the cause of the failure, embracing negative bankruptcy experiences, and undertaking a series of coping measures. This enables them to develop an internal attributional style by taking control of their actions, increase their self-efficacy, and benefit from the bankruptcy by developing antifragility as an ‘entrepreneurial competence’. Second, this competence allows the venture founders to engage in long-term reflexive and experiential learning behaviours which allow the business owners to prospectively sense-make and form deeper high-order moments of learning which are harnessed to restart. Third, a range of supporting organising practices were found to impact the development of antifragility. A theoretical grounded model has been formed through a synthesis of the research findings. The model encompasses the steps and factors involved in returning to entrepreneurship post-bankruptcy by forming antifragility as an organising capability. A series of practical implications, and some relevant policy implications of the study are set out to support the effective management of entrepreneurship and bankruptcy in practice

Primary pure non-gestational choriocarcinoma of ovary: a rare case report

Germ cell malignancies represent 15% of ovarian cancers. Choriocarcinoma is a malignant tumour with trophoblastic differentiation. It may be gestational or non-gestational and may be a primary tumour or metastatic from other organs. Pure non-gestational choriocarcinoma is an extremely rare neoplasm, with reports of only a few cases. This study reports a rare case of non-gestational pure choriocarcinoma in a postmenarcheal young female and describes details of the tumour, including the clinicopathological findings. A young female presented with sudden onset anxiety, abdominal distention, severe abdominal pain, and severe pallor. Clinically, she was diagnosed as a case of ruptured ectopic pregnancy, and was taken up for emergency laparotomy. A right ovarian mass of 5X7 cm was seen, which was ruptured and was bleeding profusely. Right salpingo-oophorectomy was done, and it was diagnosed histopathologically as primary pure non-gestational choriocarcinoma of ovary. This case report describes the histopathological and immunohistochemical findings of this rare entity, as well as the various methods to differentiate between cases of non-gestational and gestational choriocarcinoma of the ovary. This is important as non-gestational choriocarcinoma has a poorer prognosis in comparison with gestational. Also, the treatment regimen for the two differs

Performance Analysis of GaN/AlGaN HEMTs Passivation using Inductively Coupled Plasma Chemical Vapour Deposition and Plasma Enhanced Chemical Vapour Deposition Techniques

In the present paper SiN thin film has been studied as a passivation layer and its effect on AlGaN/GaN HEMTs is investigated using two different deposition techniques i.e PECVD and ICPCVD. AlGaN/GaN HEMTs devices passivated with optimised SiN film have delivered lower gate leakage current (from μA to nA). Device source drain saturation current (Ids) increased from 400mA/mm to ~550 A/mm and the peak extrinsic trans-conductance increased from 100 mS/mm to 170 mS/mm for a 0.8 μm HEMT device. The optimised SiN passivation process has resulted in reduced current collapse and increased breakdown voltage for HEMT devices.

Synchronous mucinous cystadenoma ovary, leiomyoma uterus and mucinous adenocarcinoma cervix infiltrating into uterine leiomyoma: a rare case report

The overall incidence of synchronous female genital tract malignancies is 0.63%. The most frequently observed synchronous neoplasms are those of the ovary together with the endometrium. Cervical and ovarian malignancies are exceedingly rare. We present the case of a female patient who complained of abdominal distention and pain abdomen. A cervical pap smear was performed, and it showed inflammation and atrophic changes. USG abdomen revealed findings consistent with pyometra. Repeated dilatation and curretage for resolving the pyometra was attempted, but it yielded mucinous fluid only. Another USG abdomen was done, which showed a cervical growth. The patient was taken up for staging laparotomy. Per operatively, no growth could be identified in the cervix. However, dense adhesions of the cervix with the bladder were present. A bilateral salpingo-oophorectomy specimen was sent for intraoperative cytology, and showed mucinous cystadenoma, ovary. Further, the completion total hysterectomy specimen was sent for histopathology. Sections showed adenocarcinoma, cervix and leiomyoma, uterus. The cervical adenocarcinoma showed infiltration into the uterine leiomyoma. Thus, we document a very rare case involving a patient who presented with three coexistent tumours involving bilateral ovaries and uterus. To our knowledge, this is the first reported case of the combination. Accurate diagnosis as separate independent primary tumours or as primary tumour associated with its metastasis, and identification the site of origin in secondary tumours has important prognostic implications and is necessary for appropriate staging and treatment

Phoenix rising: Rebounding to venture again post firm-failure

Despite extant literature on a failed firm owner's coping, learning, and emotional functioning, very little is known about how once bankrupted B2B entrepreneurs rebound to venture again and develop capabilities like antifragility. Drawing on antifragility as a lens, we explore how UK B2B firm owners bounce back from bankruptcy and external crises to pursue successful ventures. Empirically, we examine the retrospective accounts of 20 formerly bankrupted UK-based entrepreneurs who overcame their adversity to venture again. Our study suggests that emotional and reflective coping strategies are key to developing the business owners' internal attributional style towards their failure, which in turn help them to cultivate what we term antifragility as an ‘entrepreneurial competence’. This capability prompts long-term learning behaviours which generate deep insights into exploring and exploiting opportunities and limits otherwise overlooked by others to restart a new venture. Emphasizing the role of dealing with emotions associated with failure and coping with uncertainties, our study provides nuanced insight into how once bankrupted B2B entrepreneurs overcome a firm demise to rebound to venture again and learn in the long-term. Implications for entrepreneurial re-entry post-failure are explored

Performance analysis of InAlN/GaN HEMT and optimization for high frequency applications

An InAlN/GaN HEMT device was studied using extensive temperature dependent DC IV measurements and CV measurements. Barrier traps in the InAlN layer were characterized using transient analysis. Forward gate current was modelled using analytical equations. RF performance of the device was also studied and device parameters were extracted following small signal equivalent circuit model. Extensive simulations in Silvaco TCAD were also carried out by varying stem height, gate length and incorporating back barrier to optimize the suitability of this device in Ku-band by reducing the detrimental Short Channel Effects (SCEs). In this paper a novel structure i.e., a short length T gate with recess, on thin GaN buffer to achieve high cut-off frequency (f$_T$) and high maximum oscillating frequency (f$_{max}$) apt for Ku-band applications is also proposed

Design and Fabrication of Multi-finger Field Plate for Enhancement of AlGaN/GaN HEMT Breakdown Voltage

The design and fabrication of gate/source connected multi-finger field plate structures using TCAD ATLAS simulation software is presented. The designed field plate structures are fabricated on indigenous AlGaN/GaN HEMT devices. AlGaN/GaN HEMT devices with field plate structures exhibit about three times improvement in breakdown voltage of device and are in close agreement with the simulation results. Integration of field plates in device have resulted in higher VDS (drain to source voltage) operation and improvement in output power of AlGaN/GaN HEMT devices. Incorporation of field plates also decrease the reverse leakage current of HEMT devices