A rare case of heterotopic pregnancy: an avalanche of catastrophe

An ectopic pregnancy is the development of an embryo outside the uterus, a major cause of maternal morbidity and mortality. Heterotopic pregnancy is when an intrauterine implanted embryo develops simultaneously along with an extra uterine implantation. With rising incidence of assisted reproductive technology (ART), incidence of ectopic pregnancy is on a rise. We report a case of an elderly patient, conceived by in vitro fertilization and embryo transfer (IVF-ET), who had a catastrophe of events following conception, where she had an intrauterine twin gestation and an ectopic gestation in the left fallopian tube. She presented with vomiting and on ultrasound scan, we found a twin intra uterine gestation, with demise of one twin with no sign of ectopic implantation. Initially we decided to continue pregnancy. However, she had persistent spotting per vagina, and on a repeat ultrasound scan there was intrauterine demise of the other foetus also. Her uterus was then evacuated under anaesthesia. Post operatively, she became hemodynamic ally unstable and ultrasound was inconclusive of the cause. So, we subjected her to an MRI which showed a left adnexal ruptured ectopic pregnancy with hemoperitoneum. She was immediately taken up for exploratory laparotomy and left salpingectomy was done hemoperitoneum evacuated. Due to timely intervention and use of advanced techniques for diagnosis, she recovered successfully. Thus, heterotopic pregnancy can be a rare, life threatening complication of IVF, a vigilant eye and not shying away from the use of novel and advanced techniques for diagnosis, can help in early diagnosis and timely intervention and thus prove to be lifesaving.

Microscopic mechanisms of thermal and driven diffusion of non rigid molecules on surfaces

The motion of molecules on solid surfaces is of interest for technological applications such as catalysis and lubrication, but it is also a theoretical challenge at a more fundamental level. The concept of activation barriers is very convenient for the interpretation of experiments and as input for Monte Carlo simulations but may become inadequate when mismatch with the substrate and molecular vibrations are considered. We study the simplest objects diffusing on a substrate at finite temperature $T$, namely an adatom and a diatomic molecule (dimer), using the Langevin approach. In the driven case, we analyse the characteristic curves, comparing the motion for different values of the intramolecular spacing, both for T=0 and $T\ne 0$. The mobility of the dimer is higher than that of the monomer when the drift velocity is less than the natural stretching frequency. The role of intramolecular excitations is crucial in this respect. In the undriven case, the diffusive dynamics is considered as a function of temperature. Contrary to atomic diffusion, for the dimer it is not possible to define a single, temperature independent, activation barrier. Our results suggest that vibrations can account for drastic variations of the activation barrier. This reveals a complex behaviour determined by the interplay between vibrations and a temperature dependent intramolecular equilibrium length.Comment: 6 pages, 5 figures, Proceeding of the EMRS 2002 Conference, to be published in Thin Solid Film

Probing muonic charged current nonstandard interactions at decay-at-rest facilities in conjunction with T2HK

The muon decay-at-rest ($\mu$-DAR) facility provides us with an ideal platform to probe purely muonic charged-current nonstandard neutrino interactions (NSIs). We propose to probe this class of NSI effects using antineutrinos from a $\mu$-DAR source in conjunction with neutrinos from the future Tokai to Kamioka superbeam experiment with megaton Hyper Kamiokande detector (T2HK). Even though muonic NSIs are absent in neutrino production at T2HK, we show that our proposed hybrid setup comprising $\mu$-DAR and T2HK helps in alleviating the parameter degeneracies that can arise in data. Analytic considerations reveal that the oscillation probability is most sensitive to the NSI parameter in the $\mu$-e sector. For this parameter, we show that the $\mu$-DAR setup can improve on the existing bounds down to around 0.01, especially when the data are combined with neutrino data from T2HK experiment due to the lifting of parameter degeneracies. The high precision with which $\mu$-DAR can measure $\delta_{\rm{CP}}$ is shown to be robust even in the presence of the considered NSIs. Finally, we show that the combination of $\mu$-DAR along with T2HK can also be used to put mild constraints on the NSI phase in the vicinity of the maximal CP-violating value for the chosen benchmark value of $\varepsilon^{\mu e}_{\mu e}=0.01$.Comment: Matches version published in Phys. Rev.

A Survey on Implementation of Homomorphic Encryption Scheme in Cloud based Medical Analytical System

The privacy of sensitive personal information is more and more important topic as a result of the increased availability of cloud services. These privacy issues arise due to the legitimate concern of a) having a security breach on these cloud servers or b) the leakage of this sensitive information due to an honest but curious individual at the cloud service provider. Standard encryption schemes try to address the ?rst concern by devising encryption schemes that are harder to break, yet they don’t solve the possible misuse of this sensitive data by the cloud service providers. Homomorphic encryption presents a tool that can solve both types of privacy concerns. The clients are given the possibility of encrypting their sensitive information before sending it to the cloud. The cloud will then compute over their encrypted data without the need for the decryption key. By using homomorphic encryption, servers guarantee to the clients that their valuable information to have no problems after being in a difficult situation.

A rare case of acute non-puerperal uterine inversion due to large leiomyoma in COVID pandemic: challenges in clinical diagnosis and management

Non puerperal uterine inversion is a very rare clinical scenario with very few gynaecologist actually managing it in their lifetime. Acute variety of non-puerperal inversion is even rarer and thus possess diagnostic and management challenges. Case study of a rare case of a 45 years old female who was admitted for an elective surgery and had sudden acute inversion of uterus which was clinically diagnosed. Patient was managed by debulking of tumour which turned out to be large leiomyoma, followed by total abdominal hysterectomy. Rarity of the disease, atypical symptoms and less clinical exposure to such cases pose diagnostic as well as surgical challenges as in our case

Quantifying black carbon deposition over the Greenland ice sheet from forest fires in Canada

Black carbon (BC) concentrations observed in 22 snowpits sampled in the northwest sector of the Greenland ice sheet in April 2014 have allowed us to identify a strong and widespread BC aerosol deposition event, which was dated to have accumulated in the pits from two snow storms between 27 July and 2 August 2013. This event comprises a significant portion (57% on average across all pits) of total BC deposition over 10 months (July 2013 to April 2014). Here we link this deposition event to forest fires burning in Canada during summer 2013 using modeling and remote sensing tools. Aerosols were detected by both the Cloud‐Aerosol Lidar with Orthogonal Polarization (on board CALIPSO) and Moderate Resolution Imaging Spectroradiometer (Aqua) instruments during transport between Canada and Greenland. We use high‐resolution regional chemical transport modeling (WRF‐Chem) combined with high‐resolution fire emissions (FINNv1.5) to study aerosol emissions, transport, and deposition during this event. The model captures the timing of the BC deposition event and shows that fires in Canada were the main source of deposited BC. However, the model underpredicts BC deposition compared to measurements at all sites by a factor of 2–100. Underprediction of modeled BC deposition originates from uncertainties in fire emissions and model treatment of wet removal of aerosols. Improvements in model descriptions of precipitation scavenging and emissions from wildfires are needed to correctly predict deposition, which is critical for determining the climate impacts of aerosols that originate from fires

�Synchronous Modulation In An Inverter Fed Motor Drive For Recovering Energy From Matching Long Cable ��

In this paper, we understood the significance of bit rate investigation of the approaching bundle. We additionally comprehended that if the bit rate is not dissected, then there is wastefulness in system execution. This examination study will demonstrate a decent base for further research in the territory of bit rate investigation of bundle landings. In this paper we had broke down the throughput, parcel delay, bundle conveyance proportion, jitter, vitality devoured and the examination as for no. of bundles sent is performed. Thusly we can accomplish the objective of enhancing bit rate bundle investigation coming about system proficiency. The most recent adaptation of system test system will be most useful in development of system and follow document in it is additionally helpful. In future, the framework could be created on the equipment and the execution assessment could be checked continuously. The deferral is an imperative parameter if there should arise an occurrence of ongoing activity. The postponement ought to be diminished or else it prompts unsafe circumstance on the off chance that hard continuous frameworks. Thus, it would be an awesome future work to build up the framework on the equipment and checking of execution assessment progressively

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF PACLITAXEL LOADED SOLID LIPID NANOPARTICLES AS A COLLOIDAL DRUG CARRIER

Objective: This study was aimed to design and characterize Paclitaxel-loaded Solid Lipid Nanoparticles (SLNs) to achieve site specificity,reduce toxicity and sustained release pattern. Methods: Paclitaxel-loaded solid lipid nanoparticles were fabricated by microemulsion followed by probe sonication technique using stearic acid as lipid and stabilized of the mixture of surfactants. In this study, 32 full factorial design was employed for optimizing the concentration of lipid as stearic acid and surfactant (soya lecithin) for the nanoparticles. The optimization was done by studying the dependent variable of particle size and % entrapment efficiency. Results: The results showed that the paclitaxel-loaded solid lipid nanoparticles prepared with the concentration of 33.31 % stearic acid and 500 mg of soya lecithin were optimum characteristic than other formulations. They showed the average particles size 149±4.10 nm and PDI 250±2.04. The zeta potential, % EE and % drug loading capacity was found to be respectively-29.7, 93.38±1.90 and 0.81±0.01. The optimized batch of Paclitaxel SLNs exhibited spherical shape with smooth surface analyzed by Transmission Electron Microscopy. In vitro study showed sustained release profile and was found to follow Higuchi Kinetics Equation. Conclusion: The SLNs of paclitaxel m et al. l the requirements of a colloidal drug delivery system. They had a particle size in nanosize; their size distribution was narrow and all the particles were in a spherical shape