Partitioning response inhibition by its latency, extent, and electrophysiological correlates

Inhibition is one of the core concepts in cognitive neuroscience, referring to a higher-order control mechanism that can arrest or cancel the output of other functional systems. Inhibition of motor responses is assumed to serve as a proxy for cognitive inhibition, and impaired motor inhibition may thus constitute an endophenotype for at-risk behavior regarding poor impulse control and related psychiatric conditions. The current thesis challenges the account of a single central inhibition node by testing potential partitioning schemes of response inhibition into multiple counterparts within the motor system. First, behavioral and electrophysiological indices were compared between the most common response inhibition tasks, i.e., the go/no-go and stop signal tasks, and it was found that suppressed behavior in these tasks can be achieved via separable mechanisms. Secondly, hypothetical partitioning schemes between fast global and slow selective inhibition mechanisms were tested. While no conclusive evidence was found in support of such a dissociation in two independent studies, evidence was found for a pivotal role of proactive control in shaping the sensory, attentional, and motor parameters that play a role in successful inhibition. Altogether, the results suggest that action cancellation may be achieved via dynamic interactions within the motor control system incorporating action planning, selection, and inhibition, which further interacts with the proactive goal-driven cognitive system

The Temporal Dynamics of Response Inhibition and their Modulation by Cognitive Control

Behavioral adjustments require interactions between distinct modes of cognitive control and response inhibition. Hypothetically, fast and global inhibition is exerted in the reactive control mode, whereas proactive control enables the preparation of inhibitory pathways in advance while relying on the slower selective inhibitory system. We compared the temporal progression of inhibition in the reactive and proactive control modes using simultaneous electroencephalography (EEG) and electromyography (EMG) recordings. A selective stop signal task was used where go stimuli required bimanual responses, but only one hand’s response had to be suppressed in stop trials. Reactive and proactive conditions were incorporated by non-informative and informative cues, respectively. In 47% of successful stop trials, subthreshold EMG activity was detected that was interrupted as early as 150 ms after stop stimulus presentation, indicating that inhibition occurs much earlier than previously thought. Inhibition latencies were similar across the reactive and proactive control modes. The EMG of the responding hand in successful selective stop trials indicated a global suppression of ongoing motor actions in the reactive condition, and less inhibitory interference on the ongoing actions in the proactive condition. Group-level second order blind separation (SOBI) was applied to the EEG to dissociate temporally overlapping event-related potentials. The components capturing the N1 and N2 were larger in the reactive than the proactive condition. P3 activity was distributed across four components, three of which were augmented in the proactive condition. Thus, although EEG indices were modulated by the control mode, the inhibition latency remained unaffected

Hippocampal-cortical functional connectivity during memory encoding and retrieval. Supplementary materials.

Data, analysis code, and analyses report

Inhibitory Control and the Structural Parcelation of the Right Inferior Frontal Gyrus

The right inferior frontal gyrus (rIFG) has most strongly, although not exclusively, been associated with response inhibition, not least based on covariations of behavioral performance measures and local gray matter characteristics. However, the white matter microstructure of the rIFG as well as its connectivity has been less in focus, especially when it comes to the consideration of potential subdivisions within this area. The present study reconstructed the structural connections of the three main subregions of the rIFG (i.e., pars opercularis, pars triangularis, and pars orbitalis) using diffusion tensor imaging, and further assessed their associations with behavioral measures of inhibitory control. The results revealed a marked heterogeneity of the three subregions with respect to the pattern and extent of their connections, with the pars orbitalis showing the most widespread inter-regional connectivity, while the pars opercularis showed the lowest number of interconnected regions. When relating behavioral performance measures of a stop signal task to brain structure, the data indicated an association between the dorsal opercular connectivity and the go reaction time and the stopping accuracy

Library of Samples for E-Vehicle Propulsion Drive Tuning

The majority of testing cycles for the vehicle comparison is the long-term cycles and could not be used for the short-term transient mode imitations. Also, all the used nowadays testing cycles were designed for internal combustion engine vehicles and take into account not only energy and mechanical aspects, but also pollution and internal combustion engine characteristics. The paper presents a collection of sample signals developed to explore and simulate multiple system impacts to emulate different reference and load conditions. The study describes the major driving modes, such as the constant-speed cruising, speeding up and braking, typical parking regimes, uphill and downhill motion, and taking a turn. The developed testing equipment and software are described. Responses of the battery vehicle drives to the changeable controls and disturbances were studied in the laboratory test bench. The set of test cycles prepared in the frame of the ABB control arrangement was applied to the system evaluation and assessment. The developed methodology can be recommended to adjust the electric drives for different kinds of testing equipment. Experimental validation of the described approach has demonstrated the broad possibilities for the steady-state and transient modes of vehicle quality evaluation. It suits for recommendations that can be made with regard to the tuning of the drive regulators, control looping, sensor allocation, and feedback arrangements

A Library of Samples for E-Vehicle Propulsion Drive Tuning

The majority of testing cycles for the vehicle comparison is the long-term cycles and could not be used for the short-term transient mode imitations. Also, all the used nowadays testing cycles were designed for internal combustion engine vehicles and take into account not only energy and mechanical aspects, but also pollution and internal combustion engine characteristics. The paper presents a collection of sample signals developed to explore and simulate multiple system impacts to emulate different reference and load conditions. The study describes the major driving modes, such as the constant-speed cruising, speeding up and braking, typical parking regimes, uphill and downhill motion, and taking a turn. The developed testing equipment and software are described. Responses of the battery vehicle drives to the changeable controls and disturbances were studied in the laboratory test bench. The set of test cycles prepared in the frame of the ABB control arrangement was applied to the system evaluation and assessment. The developed methodology can be recommended to adjust the electric drives for different kinds of testing equipment. Experimental validation of the described approach has demonstrated the broad possibilities for the steady-state and transient modes of vehicle quality evaluation. It suits for recommendations that can be made with regard to the tuning of the drive regulators, control looping, sensor allocation, and feedback arrangements

Differences in unity: The go/no-go and stop signal tasks rely on different mechanisms

Response inhibition refers to the suppression of prepared or initiated actions. Typically, the go/no-go task (GNGT) or the stop signal task (SST) are used interchangeably to capture individual differences in response inhibition. On the one hand, factor analytic and conjunction neuroimaging studies support the association of both tasks with a single inhibition construct. On the other hand, studies that directly compare the two tasks indicate distinct mechanisms, corresponding to action restraint and cancellation in the GNGT and SST, respectively. We addressed these contradictory findings with the aim to identify the core differences in the temporal dynamics of the functional networks that are recruited in both tasks. We extracted the time-courses of sensory, motor, attentional, and cognitive control networks by group independent component (G-ICA) analysis of electroencephalography (EEG) data from both tasks. Additionally, electromyography (EMG) from the responding effector muscles was recorded to detect the timing of response inhibition. The results indicated that inhibitory performance in the GNGT may be comparable to response selection mechanisms, reaching peripheral muscles at around 316 ​ms. In contrast, inhibitory performance in the SST is achieved via biasing of the sensorimotor system in preparation for stopping, followed by fast sensory, motor and frontal integration during outright stopping. Inhibition can be detected at the peripheral level at 140 ​ms after stop stimulus presentation. The GNGT and the SST therefore seem to recruit widely different neural dynamics, implying that the interchangeable use of superficially similar inhibition tasks in both basic and clinical research is unwarranted

The P300 as marker of inhibitory control – Fact or fiction?

Inhibitory control, i.e., the ability to stop or suppress actions, thoughts, or memories, represents a prevalent and popular concept in basic and clinical neuroscience as well as psychology. At the same time, it is notoriously difficult to study as successful inhibition is characterized by the absence of a continuously quantifiable direct behavioral marker. It has been suggested that the P3 latency, and here especially its onset latency, may serve as neurophysiological marker of inhibitory control as it correlates with the stop signal reaction time (SSRT). The SSRT estimates the average stopping latency, which itself is unobservable since no overt response is elicited in successful stop trials, based on differences in the distribution of go reaction times and the delay of the stop-relative to the go-signal in stop trials. In a meta-analysis and an independent electroencephalography (EEG) experiment, we found that correlations between the P3 latency and the SSRT are indeed replicable, but also unspecific. Not only does the SSRT also correlate with the N2 latency, but both P3 and N2 latency measures show similar or even higher correlations with other behavioral parameters such as the go reaction time or stopping accuracy. The missing specificity of P3–SSRT correlations, together with the general pattern of associations, suggests that these manifest effects are driven by underlying latent processes other than inhibition, such as behavioral adaptations in context of performance monitoring operations

tDCS over the inferior frontal gyri and visual cortices did not improve response inhibition

The ability to cancel an already initiated response is central to flexible behavior. While several different behavioral and neural markers have been suggested to quantify the latency of the stopping process, it remains unclear if they quantify the stopping process itself, or other supporting mechanisms such as visual and/or attentional processing. The present study sought to investigate the contributions of inhibitory and sensory processes to stopping latency markers by combining transcranial direct current stimulation (tDCS), electroencephalography (EEG) and electromyography (EMG) recordings in a within-participant design. Active and sham tDCS were applied over the inferior frontal gyri (IFG) and visual cortices (VC), combined with both online and offline EEG and EMG recordings. We found evidence that neither of the active tDCS condition affected stopping latencies relative to sham stimulation. Our results challenge previous findings suggesting that anodal tDCS over the IFG can reduce stopping latency and demonstrates the necessity of adequate control conditions in tDCS research. Additionally, while the different putative markers of stopping latency showed generally positive correlations with each other, they also showed substantial variation in the estimated latency of inhibition, making it unlikely that they all capture the same construct exclusively