Ceramika osadowa kultury przeworskiej z Leimbach, powiat Nordhausen

Von 2010 bis 2014 erfolgte die großflächige Ausgrabung einer spätlatènezeitlichen Siedlung der Przeworsk-Kultur bei Leimbach, Lkr. Nordhausen, am Nordrand der nordthüringischen Goldenen Aue. Es handelt sich um eine von mehreren Fundstellen im Landkreis Nordhausen, auf denen Keramik im Stil der spätlatènezeitlichen Przeworsk-Kultur den größten Fundanteil stellt und die sich unmittelbar mit gleichzeitigen Siedlungen des Kerngebietes der Przeworsk-Kultur vergleichen lassen.Gleichzeitig wird damit der Nachweis einer Migration von Siedlern der Przeworsk-Kultur während der jüngeren vorrömischen Eisenzeit in das nordthüringische Südharzvorland erbracht

Ärztliches Karrierekonzept und Selbstkonzept bei Medizinstudierenden in Ost- und West-Berlin

Nach der Selbstkonzept-Theorie der beruflichen Entwicklung ist eine Person in einem Beruf um so erfolgreicher, je besser ihr Selbstkonzept und ihr subjektives Berufskonzept übereinstimmen. In einer West-Berliner Studie zum ärztlichen Berufskonzept zeigte sich, daß von Medizinstudierenden für eine berufliche Karriere im Krankenhaus in erster Linie solche Eigenschaften als förderlich eingestuft wurden, die eher dem männlichen als dem weiblichen Geschlechtsstereotyp entsprechen, und daß Frauen am Ende des Medizinstudiums eine deutlich größere Diskrepanz zwischen subjektivem Karrierekonzept und Selbstkonzept wahrnahmen als ihre männlichen Kommilitonen. Da sich das ärztliche Berufsfeld und die Situation der Frau in der ehemaligen DDR in wesentlichen Punkten von der Situation in Westdeutschland unterschied, bestand die Vermutung, daß sich dies auch im Karrierekonzept und Selbstkonzept von angehenden Ärzten und Ärztinnen niederschlagen würde. Bei dem Vergleich mit einer Ost-Berliner Stichprobe von Medizinstudierenden zeigten sich weniger Ost-West-Unterschiede als erwartet. Auch in Ost-Berlin galten maskuline Attribute für eine berufliche Karriere im Krankenhaus als besonders förderlich, während feminine Eigenschaften als wenig förderlich eingeschätzt wurden. Im Karrierekonzept wie im Selbstkonzept erschien der Geschlechtsunterschied bedeutsamer als der gesellschaftliche Unterschied. Auch in Ost-Berlin klafften bei den Frauen am Ende des Medizinstudiums die bei den Konzepte am weitesten auseinander; sie hatten ein besonders maskulines Karrierekonzept und beschrieben sich selbst gleichzeitig als ausgesprochen feminin

Untersuchung von Konzepten zur CO2-Abtrennung in Kombikraftwerken mit integrierter Wirbelschichtvergasung: Untersuchung von Konzepten zur CO2-Abtrennung in Kombikraftwerken mit integrierter Wirbelschichtvergasung

Im Rahmen dieser Arbeit werden Konzepte für Gasaufbereitung in Kombikraftwerken mit integrierter Wirbelschichtvergasung und CO2-Abtrennung untersucht (IGCC-CCS). Dabei stehen die Konvertierung von Kohlenmonoxid (CO-Shift) und die Einbindung dieses Prozeß-schrittes in ein IGCC-CCS-Kraftwerk im Mittelpunkt. Ziel der Arbeit ist die energetische und wirtschaftliche Bewertung von Konzepten zur CO2-Abtrennung für ein ab 2015 baubares, grundlastfähiges IGCC-CCS-Kraftwerk der 800-MW-Klasse. Dazu werden neben den bekannten konventionellen, mehrstufigen Konzepten der Rohgas- und Reingas-Shift weitere alternative Ansätze zur Steigerung des Anlagenwirkungsgrades sowie zur Senkung der spezifischen CO2-Emission verfolgt. Die Ergebnisse der mit Hilfe von ASPEN Plus und EBSILON Professional durchgeführten Prozesssimulationen werden im Vergleich zu Dampfkraftwerken neuester Bauart wirtschaftlich bewertet

Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma is in most transplant regions a contraindication for liver transplantation, even ruling out an active waiting list registration. However, recent studies showed that well-selected patients after a neo-adjuvant treatment benefit from liver transplantation with good long-term outcomes. The role of living donor liver transplantation is unclear for this indication. The current study focuses on LDLT for intrahepatic cholangiocarcinoma

Разработка плана тактических действий по тушению пожаров в зданиях повышенной этажности (на примере жилого дома с административными помещениями, этажность 25)

Анализ пожаров в городе Новокузнецке показывает, что около 70% пожаров происходит в жилом секторе. При этом в жилье гибнет при пожарах около 80% людей по последним статистическим данным. Объектом исследования является жилой дом, расположенный в городе Новокузнецке, центральный район. Цель дипломного проекта – разработать тактические действия по тушению пожаров в зданиях повышенной этажности на примере вышеупомянутого объекта исследования. В процессе исследования был проведен аналитический обзор научных трудов и информационных статей по вопросам обеспечения пожарной безопасности в зданиях промышленной этажности, представлена характеристика исследуемого объекта и факторы, влияющие на развитие пожара в высотных зданиях.Analysis of fires in the city of Novokuznetsk shows that about 70% of fires occur in the residential sector. While the housing dies in fires, about 80% of people according to recent statistics. The object of study is a residential building located in the city of Novokuznetsk Central district. The aim of the project is to develop tactical actions on a touch-NIJ fires in high-rise buildings on the example of the above-mentioned object of study. In the process of the study was an analytical review of scientific papers and news articles on issues of fire safety in buildings, industrial heights, are the characteristic of the object studied and the factors affecting the development of fire in high-rise buildings

Nanocellulose as a natural source for groundbreaking applications in materials science: Todays state

Nanocelluloses are natural materials with at least one dimension in the nano-scale. They combine important cellulose properties with the features of nanomaterials and open new horizons for materials science and its applications. The field of nanocellulose materials is subdivided into three domains: biotechnologically produced bacterial nanocellulose hydrogels, mechanically delaminated cellulose nanofibers, and hydrolytically extracted cellulose nanocrystals. This review article describes todays state regarding the production, structural details, physicochemical properties, and innovative applications of these nanocelluloses. Promising technical applications including gels/foams, thickeners/stabilizers as well as reinforcing agents have been proposed and research from last five years indicates new potential for groundbreaking innovations in the areas of cosmetic products, wound dressings, drug carriers, medical implants, tissue engineering, food and composites. The current state of worldwide commercialization and the challenge of reducing nanocellulose production costs are also discussed.Dana Kralisch and Dagmar Fischer gratefully acknowledge the Free State of Thuringia and the European Social Fund (2016 FGR 0045) for funding. Dagmar Fischer would like to thank Yvette Pötzinger and Berit Karl for the excellent editorial support. Dieter Klemm, Friederike Kramer and Katrin Petzold-Welcke are grateful for the support by the Federal Ministry of Economic Affairs and Energy, ZIM (KF2748903MF4 and KF2386003MF3). Thanks are due to the employees of Jenpolymer Materials Ltd. & Co. KG and the Polymet Jena Association, especially Priv.-Doz. Dr. Wolfgang Fried, and Prof. Dr. Raimund W. Kinne, Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Germany as well as to Dr. Detlef Gorski and Elke Langhammer, SuraChemicals GmbH, Jena, Germany for effective and helpful cooperation and stimulating interaction. Dieter Klemm and Friederike Kramer would like to thank Katharina Horn for the excellent editorial support. Miguel Gama acknowledges the funding from QREN (“Quadro de Referência Estratégica Nacional”) through the BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020-Programa Operacional Regional do Norte. Tom Lindström acknowledges RISE Bioeconomy for support and permission to publish. Emily Cranston and Stephanie Kedzior are thankful for funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) in the form of a Discovery Grant (RGPIN 402329) and PGSD graduate student scholarship, as well as support from the Faculty of Engineering at McMaster University.info:eu-repo/semantics/publishedVersio

The role of off-board EV battery chargers in smart homes and smart grids: operation with renewables and energy storage systems

Concerns about climate changes and environmental air pollution are leading to the adoption of new technologies for transportation, mainly based on vehicle electrification and the interaction with smart grids, and also with the introduction of renewable energy sources (RES) accompanied by energy storage systems (ESS). For these three fundamental pillars, new power electronics technologies are emerging to transform the electrical power grid, targeting a flexible and collaborative operation. As a distinctive factor, the vehicle electrification has stimulated the presence of new technologies in terms of power management, both for smart homes and smart grids. As the title indicates, this book chapter focuses on the role of off-board EV battery chargers in terms of operation modes and contextualization for smart homes and smart grids in terms of opportunities. Based on a review of on-board and off-board EV battery charging systems (EV-BCS), this chapter focus on the off-board EV-BCS framed with RES and ESS as a dominant system in future smart homes. Contextualizing these aspects, three distinct cases are considered: (1) An ac smart home using separate power converters, according to the considered technologies; (2) A hybrid ac and dc smart home with an off-board EV-BCS interfacing RES and ESS, and with the electrical appliances plugged-in to the ac power grid; (3) A dc smart home using a unified 2 off-board EV-BCS with a single interface for the electrical power grid, and with multiple dc interfaces (RES, ESS, and electrical appliances). The results for each case are obtained in terms of efficiency and power quality, demonstrating that the off-board EV-BCS, as a unified structure for smart homes, presents better results. Besides, the off-board EV-BCS can also be used as an important asset for the smart grid, even when the EV is not plugged-in at the smart home.(undefined

Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal sepsis

We provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients undergoing open surgery were included in a cross-sectional study and blood and skeletal muscle samples were taken. Key markers of the UPR and cluster of differentiation 68 (CD68) as surrogate of inflammatory injury were evaluated by real-time PCR and histochemical staining. CD68 mRNA increased with sepsis in skeletal muscle of patients and animals (p < 0.05). Mainly the inositol-requiring enzyme 1α branch of the UPR was upregulated as shown by elevated X-box binding-protein 1 (XBP1u) and its spliced isoform (XBP1s) mRNA (p < 0.05, respectively). Increased expression of Gadd34 indicated activation of PRKR-Like Endoplasmic Reticulum Kinase (PERK) branch of the UPR, and was only observed in mice (p < 0.001) but not human study subjects. Selected cell death signals were upregulated in human and murine muscle, demonstrated by increased bcl-2 associated X protein mRNA and TUNEL staining (p < 0.05). In conclusion we provide a first characterization of the UPR in skeletal muscle in human sepsis

EnGraft: a multicentre, open-label, randomised, two-arm, superiority study protocol to assess bioavailability and practicability of Envarsus® versus Advagraf™ in liver transplant recipients

Background Graft rejection and chronic CNI toxicity remain obstacles to organ transplant success. Current formulations of tacrolimus, such as Prograf® and Advagraf™, exhibit limitations in terms of pharmacokinetics and tolerability, related in part to suboptimal bioavailability. As dosing non-compliance can result in graft rejection, the once daily formulation of tacrolimus, Advagraf™, was developed (vs 2x/day Prograf®). Benefits of Advagraf™ are counterbalanced by delayed achievement of therapeutic trough levels and need for up to 50% higher doses to maintain Prograf®-equivalent troughs. Envarsus® is also a prolonged-release once-daily tacrolimus formulation, developed using MeltDose™ drug-delivery technology to increase drug bioavailability; improved bioavailability results in low patient drug absorption variability and less pronounced peak-to-trough fluctuations. In phase III de novo kidney transplant studies, Envarsus® proved non-inferior to twice-daily tacrolimus; however, no phase IV studies show superiority of Envarsus® vs Advagraf™ in de novo liver transplant (LTx) recipients. Methods The EnGraft compares bioavailability and tests superiority of Envarsus® (test arm) versus Advagraf™ (comparator arm) in de novo LTx recipients. A total of 268 patients from 15 German transplant centres will be randomised 1:1 within 14 days post-LTx. The primary endpoint is dose-normalised trough level (C/D ratio) measured 12 weeks after randomisation. Secondary endpoints include the number of dose adjustments, time to reach first defined trough level and incidence of graft rejections. Additionally, clinical and laboratory parameters will be assessed over a 3-year period. Discussion C/D ratio is an estimate for tacrolimus bioavailability. Improving bioavailability and increasing C/D ratio using Envarsus could reduce renal dysfunction and other tacrolimus-related toxicities; previous trials have shown that a higher C/D ratio (i.e. slower tacrolimus metabolism) is not only associated with improved renal function but also linked to reduced neurotoxic side effects. A higher C/D ratio could improve clinical outcomes for LTx recipients; EnGraft has begun, with one third of patients recruited by January 2022