Synthesis and characterization of nano sized (Zn,Cd)S mixed phosphors

Present paper reports synthesis and characterization of (Zn,Cd)S mixed phosphors. Sample was synthesized with modified chemical route method which is suitable for large scale production and economical with pollution free technique. Prepared sample was characterized by PXRD (Powder X-ray Diffraction technique) and average crystalline sizes were calculated by Debye-Scherer formula which was verified by FEGSEM (Field emission gun scanning electron microscopy) technique. The average particles sized were found at 5-55nm range

Experimental investigation of ball bearing lubrication conditions by shock pulse method

Lubricant (grease) is a vital requirement of ball bearing system. Grease not only protects ball bearing from wear and tear but performs various other functions that are essential for proper functioning of ball bearings. The lubricant (grease) under different conditions attains different properties which in turn affect the performance of the ball bearings. The effect of the condition of the lubricants on the performance of the ball bearings is well documented. the work reports about the investigation of ball bearing using shock pulse method by using two different instruments (Tester T2000 Model and Shock Pulse Meter 43A) of different operating conditions of ball bearing the condition such as used the quantity of grease as different percentage (0%, 25%, 50%, 75%, 100%) and bad quality grease (burn grease) at different rpm at a fixed load (10kg) and compare the normalized shock pulse value (dB) at different operating conditions. This method uses a piezo-electric accelerometer superimposed electrically as well as mechanically to about 32 kHz of resonant frequency. The result will help in bearing related to quantity as well as quality condition based maintenance choosing the optimum conditions for detecting the lubricant problem in ball bearing

Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue.

Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and transplantable human fetal retina provides an opportunity for evaluating and modeling retinal tissue replacement strategies in relevant animal models in the effort to develop a functional retinal patch to restore vision in patients with profound blindness caused by retinal degeneration. Because of the complexity of this very promising approach requiring specialized stem cell and grafting techniques, the tasks of retinal tissue derivation and transplantation are frequently split between geographically distant teams. Delivery of delicate and perishable neural tissue such as retina to the surgical sites requires a reliable shipping protocol and also controlled temperature conditions with damage-reporting mechanisms in place to prevent transplantation of tissue damaged in transit into expensive animal models. We have developed a robust overnight tissue shipping protocol providing reliable temperature control, live monitoring of the shipment conditions and physical location of the package, and damage reporting at the time of delivery. This allows for shipping of viable (transplantation-competent) hPSC-derived retinal tissue over large distances, thus enabling stem cell and surgical teams from different parts of the country to work together and maximize successful engraftment of organoid-derived retinal tissue. Although this protocol was developed for preclinical in vivo studies in animal models, it is potentially translatable for clinical transplantation in the future and will contribute to developing clinical protocols for restoring vision in patients with retinal degeneration

Post Harvest Technology of Papaya Fruits and It’S Value Added Products-A Review

Helicoverpa armigera (Hubner) is considered one of the most important pests in agriculture globally. As it is a polypahgous pest and infests more than 180 plants, it causes huge economic loss annually. It is a native to India and is widely distributed throughout the country. Agriculturists have taken several measures to control this pest. Earlier methods include the use of chemical pesticides and insecticides. In recent times, more attention is being paid to the biological control methods such as use of natural enemies, pheromones, neuropeptides, development of transgenic crops, RNA interference technology etc. These methods though have faced some challenges in implementation but are safe, sustainable and mostly species specific. Here, we have discussed the chemical and biological methods that have been used in the past or are currently in practice. We have also discussed some of quite recent but promising technologies which in future can be developed as a tool for the control of Helicoverpa armigera

Post Harvest Technology of Papaya Fruits and It’S Value Added Products-A Review

Helicoverpa armigera (Hubner) is considered one of the most important pests in agriculture globally. As it is a polypahgous pest and infests more than 180 plants, it causes huge economic loss annually. It is a native to India and is widely distributed throughout the country. Agriculturists have taken several measures to control this pest. Earlier methods include the use of chemical pesticides and insecticides. In recent times, more attention is being paid to the biological control methods such as use of natural enemies, pheromones, neuropeptides, development of transgenic crops, RNA interference technology etc. These methods though have faced some challenges in implementation but are safe, sustainable and mostly species specific. Here, we have discussed the chemical and biological methods that have been used in the past or are currently in practice. We have also discussed some of quite recent but promising technologies which in future can be developed as a tool for the control of Helicoverpa armige

Post Harvest Technology of Papaya Fruits and It’S Value Added Products-A Review

Helicoverpa armigera (Hubner) is considered one of the most important pests in agriculture globally. As it is a polypahgous pest and infests more than 180 plants, it causes huge economic loss annually. It is a native to India and is widely distributed throughout the country. Agriculturists have taken several measures to control this pest. Earlier methods include the use of chemical pesticides and insecticides. In recent times, more attention is being paid to the biological control methods such as use of natural enemies, pheromones, neuropeptides, development of transgenic crops, RNA interference technology etc. These methods though have faced some challenges in implementation but are safe, sustainable and mostly species specific. Here, we have discussed the chemical and biological methods that have been used in the past or are currently in practice. We have also discussed some of quite recent but promising technologies which in future can be developed as a tool for the control of Helicoverpa armigera

Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

Introduction: Younger women with breast carcinoma (BC) exhibits more aggressive pathologic features compared to older women; young age could be an independent predictor of adverse prognosis. To find any existing differences in the molecular pathogenesis of BC in both younger and older women, alterations at chromosomal (chr.) 9q22.32-22.33 region were studied owing to its association in wide variety of tumors. Present work focuses on comparative analysis of alterations of four candidate genes; PHF2, FANCC, PTCH1 and XPA located within 4.4 Mb region of the afore-said locus in two age groups of BC, as well as the interrelation and prognostic significance of alterations of these genes. Methods: Deletion analysis of PHF2, FANCC, PTCH1 and XPA were examined in a subset of 47 early-onset (group-A: ≤ 40 years) and 59 late-onset (group-B: > 40 years) breast carcinomas using both microsatellite and exonic markers. Methylation Sensitive Restriction analysis (MSRA) was done to check for promoter methylation. Quantitative real-time polymerase chain reaction (Q-PCR) and immunohistochemisty (IHC) was done in some genes to see their relative mRNA and protein expressions respectively. Clinico-pathological correlation of different parameters as well as patient survival was calculated using different statistical softwares like EpiInfo 6.04b, SPSS 10.0 etc. Results: Either age group exhibited high frequency of overall alterations in PHF2, FANCC and PTCH1 compared to XPA. Samples with alteration (deletion/methylation) in these genes showed reduced level of mRNA expression as seen by Q-PCR. Immunohistochemical analysis of FANCC and PTCH1 also supported this observation. Poor patient survival was noted in both age groups having alterations in FANCC. Similar result was also seen with PTCH1 and XPA alterations in group-A and PHF2 alterations in group-B. This reflected their roles as prognostic tools in the respective groups in which they were altered. Conclusion: Overall alterations of PHF2, FANCC and PTCH1 were comparatively higher than XPA. Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis and dysregulation of multiple DNA repair pathways as well as hedgehog dependent stem cell renewal pathway

Release of insecticidal transgenic crops and gap areas in developing approaches for more durable resistance

Transgenic cultivars expressing d-endotoxin coding genes of Bacillus thuringiensis are beinggrown globally on about 12 million hectares this year. Agriculture in India can benefit substan-tially by adopting transgenic insecticidal cultivars since, in contrast to the world average of 30%,of the total chemical pesticides used in India 75% are employed against insects. No other bio-logical approach, as safe as and yet as effective as the Bt technology is presently known to con-trol agricultural pests. The question at the center stage is to expedite the commercial release ofBt transgenics and also make a parallel effort to devise knowledge-based strategies aimed atachieving longer durability of crop resistance to insect pests. Plant breeders have encounteredsimilar situations in the past for improving crops against insects and other diseases. This articleidentifies the gap areas where research efforts are needed to develop strategies for enhancing thedurability of crop resistance