Transgenic cultivars expressing d-endotoxin coding genes of Bacillus thuringiensis are beinggrown globally on about 12 million hectares this year. Agriculture in India can benefit substan-tially by adopting transgenic insecticidal cultivars since, in contrast to the world average of 30%,of the total chemical pesticides used in India 75% are employed against insects. No other bio-logical approach, as safe as and yet as effective as the Bt technology is presently known to con-trol agricultural pests. The question at the center stage is to expedite the commercial release ofBt transgenics and also make a parallel effort to devise knowledge-based strategies aimed atachieving longer durability of crop resistance to insect pests. Plant breeders have encounteredsimilar situations in the past for improving crops against insects and other diseases. This articleidentifies the gap areas where research efforts are needed to develop strategies for enhancing thedurability of crop resistance
