Numerical analysis of flow non-uniformity in the hot gas manifold of the Space Shuttle main engine

Three-dimensional viscous flow in a conceptual hot gas manifold (HGM) for the Space Shuttle Main Engine High Pressure Fuel Turbopump (SSME HPFTP) was numerically analyzed. A finite difference scheme was used to solve the Navier-Stokes equations. The exact geometry of the SSME HGM was modeled using boundary fitted curvilinear coordinates and the General Interpolants Method (GIM) code. Slight compressibility of the subsonic flow was modeled using a linearized equation of state with artificial compressibility. A time relaxation method was used to obtain a steady state solution. The feasibility and potential usefulness of computational methods in assisting the design of SSME components which involves the flow of fluids within complex geometrical shapes is demonstrated

Low thrust orbit determination program

Logical flow and guidelines are provided for the construction of a low thrust orbit determination computer program. The program, tentatively called FRACAS (filter response analysis for continuously accelerating spacecraft), is capable of generating a reference low thrust trajectory, performing a linear covariance analysis of guidance and navigation processes, and analyzing trajectory nonlinearities in Monte Carlo fashion. The choice of trajectory, guidance and navigation models has been made after extensive literature surveys and investigation of previous software. A key part of program design relied upon experience gained in developing and using Martin Marietta Aerospace programs: TOPSEP (Targeting/Optimization for Solar Electric Propulsion), GODSEP (Guidance and Orbit Determination for SEP) and SIMSEP (Simulation of SEP)

Ballistic Limit Equations for Non-Aluminum Projectiles Impacting Dual-Wall Spacecraft Systems

One of the primary design considerations of earth-orbiting spacecraft is the mitigation of the damage that might occur from an on-orbit MMOD impact. Traditional damage-resistant design consists of a \u27bumper\u27 that is placed a small distance away from a spacecraft component or from the wall of the element in which it is housed. The performance of such a multi-wall structural element is typically characterized by its ballistic limit equation (BLE), which defines the threshold particle size that results in a failure of the spacecraft element. BLEs are also key components of any micro-meteoroid/orbital debris (MMOD) risk assessment calculations. However, these assessments often call for BLEs to predict impact response for projectiles made of materials not used in the development of those BLEs. The question naturally arises regarding how close are the predictions of such BLEs when used in impact scenarios involving projectiles made of materials not necessarily considered in their development. In an effort to address this issue, a study was performed with the objective of assessing the validity of the NNO BLE for non-aluminum particles. Particle materials considered included steel, copper, and Al2O3 (i.e. particles that are made of materials that are more dense than aluminum). Comparisons are made between actual test results involving these non-aluminum projectiles and the predictions of the NNO BLE. In nearly all cases, the NNO BLE was found not to work very well in the predicting failure / no failure response of these non-aluminum projectiles. A new NNO-type BLE is then developed that can be used to more reliably predict the response of dual-wall systems under the hypervelocity impact of such heavier non-aluminum projectiles

A First-Principles-Based Model for Crack Formation in a Pressurized Tank Following an MMOD Impact

Most robotic spacecraft have at least one pressurized vessel on board, usually a liquid propellant tank. One of the design considerations of such spacecraft is the anticipation and mitigation of the possible damage that might occur from on-orbit impacts by micro-meteoroids or orbital debris (MMOD). While considerable effort has been expended in the study of the response of non-pressurized spacecraft components to MMOD impacts, relatively few studies have been conducted on the pressurized elements of such spacecraft. In particular, since it was first proposed nearly 45 years ago, NASA\u27s current evaluation methodology for determining impact-induced failure of pressurized tanks has undergone little scrutiny. This paper presents a first-principles based model that has been developed to predict whether or not cracking might start or a through-crack might be created under an impact crater in a thin plate. This model was used to examine the effect of penetration depth on crack formation and whether or not the crack might grow through the tank wall thickness. The predictions of the model are compared to experimental data with encouraging results. The paper also develops some suggestions for future work in this area, including the extension of the first-principles model to include 3-D crack initiation modelling

Simulations of stable compact proton beam acceleration from a two-ion-species ultrathin foil

We report stable laser-driven proton beam acceleration from ultrathin foils consisting of two ion species: heavier carbon ions and lighter protons. Multi-dimensional particle-in-cell (PIC) simulations show that the radiation pressure leads to very fast and complete spatial separation of the species. The laser pulse does not penetrate the carbon ion layer, avoiding the proton Rayleigh-Taylor-like (RT) instability. Ultimately, the carbon ions are heated and spread extensively in space. In contrast, protons always ride on the front of the carbon ion cloud, forming a compact high quality bunch. We introduce a simple three-interface model to interpret the instability suppression in the proton layer. The model is backed by simulations of various compound foils such as carbon-deuterium (C-D) and carbon-tritium (C-T) foils. The effects of the carbon ions' charge state on proton acceleration are also investigated. It is shown that with the decrease of the carbon ion charge state, both the RT-like instability and the Coulomb explosion degrade the energy spectrum of the protons. Finally, full 3D simulations are performed to demonstrate the robustness of the stable two-ion-species regime.Comment: 14 pages, 10figures, to be published in PO

Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice

AbstractThioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip

Use of graphene as protection film in biological environments

Corrosion of metal in biomedical devices could cause serious health problems to patients. Currently ceramics coating materials used in metal implants can reduce corrosion to some extent with limitations. Here we proposed graphene as a biocompatible protective film for metal potentially for biomedical application. We confirmed graphene effectively inhibits Cu surface from corrosion in different biological aqueous environments. Results from cell viability tests suggested that graphene greatly eliminates the toxicity of Cu by inhibiting corrosion and reducing the concentration of Cu(2+) ions produced. We demonstrated that additional thiol derivatives assembled on graphene coated Cu surface can prominently enhance durability of sole graphene protection limited by the defects in graphene film. We also demonstrated that graphene coating reduced the immune response to metal in a clinical setting for the first time through the lymphocyte transformation test. Finally, an animal experiment showed the effective protection of graphene to Cu under in vivo condition. Our results open up the potential for using graphene coating to protect metal surface in biomedical application

Which wavenumbers determine the thermodynamic stability of soft matter quasicrystals?

For soft matter to form quasicrystals an important ingredient is to have two characteristic lengthscales in the interparticle interactions. To be more precise, for stable quasicrystals, periodic modulations of the local density distribution with two particular wavenumbers should be favored, and the ratio of these wavenumbers should be close to certain special values. So, for simple models, the answer to the title question is that only these two ingredients are needed. However, for more realistic models, where in principle all wavenumbers can be involved, other wavenumbers are also important, specifically those of the second and higher reciprocal lattice vectors. We identify features in the particle pair interaction potentials which can suppress or encourage density modes with wavenumbers associated with one of the regular crystalline orderings that compete with quasicrystals, enabling either the enhancement or suppression of quasicrystals in a generic class of systems

Primary Care Physicians’ Support of Shared Decision Making for Different Cancer Screening Decisions

Despite widespread advocacy, shared decision making (SDM) is not routinely used for cancer screening. To better understand implementation barriers, we describe primary care physicians’ (PCPs’) support for SDM across diverse cancer screening contexts