Some Aspects of Self-Concept

The purpose of this study is fourfold: (1) to investigate any differences in self-concept scores of a normal (adjusted) and abnormal (maladjusted) population; (2) to investigate any difference in self-concept scores between psychotic and non-psychotic hospitalized patients, (3) to investigate changes in self-concept concomitant with psychotherapy, and (4) to investigate any sex differences in self-concept

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Aborto, abandono, y la muerte de Augusta García Platas en Ayacucho, Perú, 1946

Resumen Augusta García Platas murió tras un aborto clandestino en Ayacucho en 1946. Este ensayo, basado en materiales del Archivo Histórico de Ayacucho, da cuenta del proceso criminal que se abrió para determinar los responsables de su muerte. A pesar de que sindicaron a ciertos individuos como culpables directos de provocar el aborto, las autoridades judiciales consideraban que la causa de fondo de la muerte de la joven había sido el abandono por parte de quienes debían velar por su salud física y moral. Este caso nos brinda la oportunidad de esclarecer las estrategias que los implicados usaban para defenderse de acusaciones criminales. Además, nos ayuda a entender las diversas deficiencias del Poder Judicial peruano de mediados del siglo XX

\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu