7 research outputs found
Site-Specific Metal Chelation Facilitates the Unveiling of Hidden Coordination Sites in an Fe II/Fe III -Seamed Pyrogallol[4]arene Nanocapsule
Under suitable conditions, C-alkylpyrogallol[4]arenes
(PgCs) arrange into spherical metal–organic nanocapsules (MONCs)
upon coordination to appropriate metal ions. Herein we present the
synthesis and structural characterization of a novel FeII/FeIII-seamed MONC, as well as studies related to its
electrochemical and magnetic behaviors. Unlike other MONCs that are
assembled through 24 metal ions, this nanocapsule comprises 32 Fe
ions, uncovering 8 additional coordination sites situated between
the constituent PgC subunits. The FeII ions are likely
formed by the reducing ability of DMF used in the synthesis, representing
a novel synthetic route toward polynuclear mixed-valence MONCs
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
In situ redox reactions facilitate the assembly of a mixed-valence metal-organic nanocapsule.
Zinc(II)-Directed Self-Assembly of Metal–Organic Nanocapsules
A metal–organic
nanocapsule consisting of 24 Zn<sup>2+</sup> ions and six pyrogallol[4]arene
units has been synthesized and structurally
characterized. All the Zn<sup>2+</sup> ions seaming the nanocapsule
are disordered over two positions forming concave distortions on the
framework
Investigating Reaction Conditions To Control the Self-Assembly of Cobalt-Seamed Nanocapsules
The synthesis and X-ray crystallographic
structure of the first
cobalt-seamed hexameric nanocapsule, [Co<sub>24</sub>(<i>C</i>-pentylpyrogallol[4]arene)<sub>6</sub>], is presented. The overall
metal–ligand arrangement of this novel capsule is similar to
that of previously reported copper- and nickel-seamed hexameric nanocapsules.
However, the title nanocapsule encloses a larger void space than those
found in previous hexameric nanocapsules
Introducing Defects into Metal-Seamed Nanocapsules Using Mixed Macrocycles
The synthesis and single-crystal
X-ray diffraction structure of
a dimeric zinc-seamed nanocapsule using a mixed pyrogallol/resorcinol[4]arene
are presented. The use of “mixed” macrocycles results
in an incomplete seam of coordination bonds around the nanocapsule’s
typically octa-metalated belt. The self-assembly of the nanocapsule
occurs such that the single resorcinol moiety of each macrocycle aligns
transversely. This yields a hepta-metalated capsule where the defect
occurs in such a way as to provide minimal disruption to the overall
structure of the nanocapsule
Introducing Defects into Metal-Seamed Nanocapsules Using Mixed Macrocycles
The synthesis and single-crystal
X-ray diffraction structure of
a dimeric zinc-seamed nanocapsule using a mixed pyrogallol/resorcinol[4]arene
are presented. The use of “mixed” macrocycles results
in an incomplete seam of coordination bonds around the nanocapsule’s
typically octa-metalated belt. The self-assembly of the nanocapsule
occurs such that the single resorcinol moiety of each macrocycle aligns
transversely. This yields a hepta-metalated capsule where the defect
occurs in such a way as to provide minimal disruption to the overall
structure of the nanocapsule