Comparison of the safety and efficacy of ivabradine and nebivolol mono- and combination therapies in the treatment of stable angina pectoris patients with left ventricular dysfunction

We aimed to investigate the pharmacoeconomic efficacy of ivabradine and nebivolol in treatment of stable angina pectoris patients with left ventricular dysfunction prospectively. Pharmacoeconomic analysis was performed by using cost minimization analysis, and cost effectiveness analysis. After 6 months treatment LVEF for the nebivolol group (17 patients, 50%) improved by (38 ± 6.5) to (41 ± 3.2), (p>0.05) and for the ivabradine group (17 patients, 50%) (37 ± 5.4) to (41 ± 2.3), (p>0.05), mean MET value in the nebivolol group increased from (3.7 ± 1.2) to (5.5 ± 1.6), (p>0.05), versus from (3.6 ± 1.5) to (5.5 ± 1.4), (p>0.05) in the ivabradine group, cost minimization analysis results showed a difference in the total cost of treatment was US$ 5288.7 in favor of nebivolol. The findings suggest that nebivolol is more cost-effective than ivabradine in the treatment of patients with left ventricular dysfunction

Türk tarım sektörü ve tarım politikaları 1980-1995

Tez (Yüksek Lisans) -- Kırıkkale Üniversitesi47806

TÜRKİYE’NİN DIŞ TİCARET YAPISI ÜZERİNE BİR UYGULAMA (1993-2002)

Süreklilik arz eden dış ticaret açıkları kriz için önemli bir gösterge olduğundan Türkiye için önemli olmaktadır. Bu nedenle, ithalat ve ihracatı içeren net ihracat fonksiyonunun tahmin edilmesi Türkiye’nin dış ticaret yapısının anlaşılması bakımından önemlidir. Bu çalışmada, Türkiye’nin net ihracat modeli tahmin edilmiş, daha sonra da bu model kullanılarak esneklikler hesaplanmıştır. Net ihracatın (1993:1-2002:4) dönemi için tahmin değerlerine göre, ihraç mallarının gelir esnekliğinin düşük, fiyat esnekliğinin ise yüksek olduğu sonucuna varılmıştır. Bunun yanında hem ithalat, hem de ihracat döviz kuruna karşı duyarlıdır. Global enflasyon oranı ile ülkenin iç enflasyon oranının artması net ihracatın artmasına neden olmaktadır. Ayrıca net ihracat ile üretim arasında negatif, ithal fiyatları arasında ise pozitif bir ilişki bulunmaktadır

Secondary prevention effectiveness in patients with stable angina

Aim. To assess the effectiveness of pharmaceutical secondary prevention in ambulatory patients with stable angina (SA), in the real-worl clinical settings. Material and methods. Retrospective analysis of randomly selected ambulatory medical histories (n=1067; year 2006) of SA patients attending Bishkek centres of family medicine. Results. The main groups of anti-anginal medications (AAM), prescribed by primary healthcare doctors, were beta-adrenoblockers (BAB; 43,0 %), nitrates (28,6 %), and calcium antagonists (CA; 27,9 %). Anti-aggregants were prescirbed to 86,8 % of the patients, and ACE inhibitors — to 82,2 %. Myocardial cytoprotectors were prescribed less often (0,5 %), as well as lipid-lowering agents (8,4 %). The prescribed doses of lipid-lowering agents were inadequately low (minimal effective doses). Generic lipid-lowering medications were prescrbed more often (93,3 %) than the original ones (6,7 %). Conclusion. Pharmaceutical secondary prevention in SA patients was not adequate and did not comply with the modern clinical guidelines

Relationship between Duke Treadmill Score and platelet volume indices in predicting coronary artery disease

Purpose — Platelet volume indices are associated with poor cardiovascular outcomes. The Duke Treadmill Score (DTS) is a composite index that is based on the results from the exercise test. The purpose of this study was to investigate the relationship between the DTS and platelet volume indices in patients with suspected coronary artery disease (CAD). Methods — A total of 1205 participants were enrolled in the study. Complete blood counts were obtained. All participants underwent an exercise test. The DTS were calculated after exercise. Demographic, clinical and echocardiographic characteristics of the patients were recorded. Results — Platelet distribution width (PDW) and especially mean platelet volume (MPV) values increase with higher DTS risk group irrespective of CAD and risk groups which is also found to be statistically significant (P<0.001). The power of the relation was powerful (r=0.911). A powerful positive relation was found between risk level and PDW (P<0.001, r=0.319). Paralleled with DTS, MPV and PDW values of the patients with CAD, hypertension, diabetes mellitus, smoking and hyperlipidemia were higher compared to those without, while MPV and PDW values were lower for the patients taking beta-blockers, angiotensin-converting-enzyme inhibitors or angiotensin receptor blockers, diuretics, aspirin and statins. When MPV (f1) and PDW (%) values were compared between groups, there was a high statistical significance between most groups. Conclusion — We found an independent association between MPV, PDW and DTS

Is increased mean platelet volume a risk factor in patients with acute deep vein thrombosis?

Objectives The purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. Methods Data were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. Results There was no significant difference between the study and control groups in mean platelet volume (8.8±1.6 vs 8.7±1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. Conclusions There was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT