37 research outputs found
Bayesian Estimation of Mixed Multinomial Logit Models: Advances and Simulation-Based Evaluations
Variational Bayes (VB) methods have emerged as a fast and
computationally-efficient alternative to Markov chain Monte Carlo (MCMC)
methods for scalable Bayesian estimation of mixed multinomial logit (MMNL)
models. It has been established that VB is substantially faster than MCMC at
practically no compromises in predictive accuracy. In this paper, we address
two critical gaps concerning the usage and understanding of VB for MMNL. First,
extant VB methods are limited to utility specifications involving only
individual-specific taste parameters. Second, the finite-sample properties of
VB estimators and the relative performance of VB, MCMC and maximum simulated
likelihood estimation (MSLE) are not known. To address the former, this study
extends several VB methods for MMNL to admit utility specifications including
both fixed and random utility parameters. To address the latter, we conduct an
extensive simulation-based evaluation to benchmark the extended VB methods
against MCMC and MSLE in terms of estimation times, parameter recovery and
predictive accuracy. The results suggest that all VB variants with the
exception of the ones relying on an alternative variational lower bound
constructed with the help of the modified Jensen's inequality perform as well
as MCMC and MSLE at prediction and parameter recovery. In particular, VB with
nonconjugate variational message passing and the delta-method (VB-NCVMP-Delta)
is up to 16 times faster than MCMC and MSLE. Thus, VB-NCVMP-Delta can be an
attractive alternative to MCMC and MSLE for fast, scalable and accurate
estimation of MMNL models
Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019
Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively. Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries