Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients

Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant status in beta-thalassemic major patients. Methods: This double blind randomized clinical trial was carried out on 120 beta thalassemic patients older than 18 years. Patients were randomly categorized in four groups. Zinc (50mg/day) and vitamin E (400mg/day) supplements were administered for former and latter group, respectively. In the third group both supplements were administered in similar doses. The fourth (control) group received no supplement. The effect of supplementations on serum zinc and vitamin E, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC) and body mass index (BMI) were measured at the beginning and the end of the study. Findings: Serum zinc levels in group 1 and 3 were significantly increased (P<0.007 and P<0.005, respectively). Serum vitamin E levels in group 2 and 3 were also increased significantly (P<0.001). Mean GPX activity in group1, 2 and 3 decreased significantly (P<0.015, P<0.032 and P<0.029, respectively). Mean SOD activity and TAC did not show significant change after supplementation. BMI had significant increase in all treated groups (P<0.001). Conclusion: Our results suggest that beta thalassemic patients have enhanced oxidative stress and administration of selective antioxidants may preclude oxidative damage. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved

Human rights education in Iranian secondary education: gaps in the curriculum

AbstractThis study investigates traces of human rights education in Iran, one of the basic internationally controversial issues in education in general and in Iranian curriculum development in particular. The study basically focused on two areas: a) concepts and components in human rights education and b) the amount of attention possibly paid to these concepts and components in Iranian Secondary Education. Three basic domains of knowledge, skills, and attitudes in relation to human rights education in Iran were considered and the amount of attention possibly paid to these was investigated in the design, administration, and evaluation of curricula for Iranian secondary education. To do this, the viewpoints of teachers, administrators, and experts were collected in a descriptive survey attempt. A researcher-made questionnaire with the Cronbach alpha reliability of 0.88 was used for data collection from 200 teachers, 27 administrators, and 15 experts. To analyze the data, descriptive and inferential statistics were used. The results suggested that the administrators, the teachers and the curriculum planners all agreed with teaching the concepts of human rights expressed in the domains of knowledge, skills and attitudes. Curriculum planners admitted that the amount of attention paid to the concepts and components of human rights was not satisfactory. There was no significant difference between the students, teachers and experts concerning the education of peace. Suggestions and implication for authorities in Iran are discussed in the light of the participants’ voices

Rectification of Sabah Stilt House Using Shear Wall Subjected to Earthquake

A moderate earthquake with 6.0-magnitude hit Sabah in 2015 especially in Ranau, Sabah has been labelled as one of the most powerful earthquakes ever in Malaysia. Numerous buildings in Sabah have become defective with the severity level of damages as absolute (non-repairable) in the RC beam-column joints and soft-storey structures. Seismic design and construction requirements were not considered in most buildings in Sabah. Hence, this research is to investigate how to mitigate the effect of earthquake on the low-rise building using a more practical and economical method. A stilt house model is developed using ABAQUS software to determine the behaviour of the stilt, low-rise building subjected to earthquake by constructing shear wall at the short columns support. There are 4 models constructed namely, frame model without shear wall (W1), with shear wall of 100mm (W2), 300mm (W3) and 500mm (W4). The results of seismic response are evaluated and compared. Different length of shear wall affects the displacement and stress of the frame model. As shear wall length increases, the displacement, stress at columns and stress at walls decreases. Thus, adding a shear wall can be used to retrofit stilt houses and a credible way to mitigate damage due to earthquake load for new houses along hill slope

Rectification of Sabah Stilt House Using Shear Wall Subjected to Earthquake

A moderate earthquake with 6.0-magnitude hit Sabah in 2015 especially in Ranau, Sabah has been labelled as one of the most powerful earthquakes ever in Malaysia. Numerous buildings in Sabah have become defective with the severity level of damages as absolute (non-repairable) in the RC beam-column joints and soft-storey structures. Seismic design and construction requirements were not considered in most buildings in Sabah. Hence, this research is to investigate how to mitigate the effect of earthquake on the low-rise building using a more practical and economical method. A stilt house model is developed using ABAQUS software to determine the behaviour of the stilt, low-rise building subjected to earthquake by constructing shear wall at the short columns support. There are 4 models constructed namely, frame model without shear wall (W1), with shear wall of 100mm (W2), 300mm (W3) and 500mm (W4). The results of seismic response are evaluated and compared. Different length of shear wall affects the displacement and stress of the frame model. As shear wall length increases, the displacement, stress at columns and stress at walls decreases. Thus, adding a shear wall can be used to retrofit stilt houses and a credible way to mitigate damage due to earthquake load for new houses along hill slope

Diagnosing students' difficulties in learning mathematics

This study considers the results of a diagnostic test of student difficulty and contrasts the difference in performance between the lower attaining quartile and the higher quartile. It illustrates a difference in qualitative thinking between those who succeed and those who fail in mathematics, illustrating a theory that those who fail are performing a more difficult type of mathematics (coordinating procedures) than those who succeed (manipulating concepts). Students who have to coordinate or reverse processes in time will encounter far greater difficulty than those who can manipulate symbols in a flexible way. The consequences of such a dichotomy and implications for remediation are then considered

Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells

Human mesenchymal stem cells (MSCs), which can generate both osteoblasts and chondrocytes, represent an ideal resource for orthopaedic repair using tissue-engineering approaches. One major difficulty for the development of osteochondral constructs using undifferentiated MSCs is that serum is typically used in culture protocols to promote differentiation of the osteogenic component, whereas existing chondrogenic differentiation protocols rely on the use of serum-free conditions. In order to define conditions which could be compatible with both chondrogenic and osteogenic differentiation in a single bioreactor, we have analysed the efficiency of new biphasic differentiation regimes based on transient serum exposure followed by serum-free treatment. MSC differentiation was assessed either in serum-free medium or with a range of transient exposure to serum, and compared to continuous serum-containing treatment. Although osteogenic differentation was not supported in the complete absence of serum, marker expression and extensive mineralization analyses established that 5 days of transient exposure triggered a level of differentiation comparable to that observed when serum was present throughout. This initial phase of serum exposure was further shown to support the successful chondrogenic differentiation of MSCs, comparable to controls maintained in serum-free conditions throughout. This study indicates that a culture based on temporal serum exposure followed by serum-free treatment is compatible with both osteogenic and chondrogenic differentiation of MSCs. These results will allow the development of novel strategies for osteochondral tissue engineering approaches using MSCs for regenerative medicine. © 2012 John Wiley & Sons, Ltd

Diet and cancer prevention: Dietary compounds, dietary MicroRNAs, and dietary exosomes

Cancer is one of main health public problems worldwide. Several factors are involved in beginning and development of cancer. Genetic and internal/external environmental factors can be as important agents that effect on emerging and development of several cancers. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A large number studies indicated that suitable dietary patterns may help to cancer prevention or could inhibit development of tumor in cancer patients. Moreover, a large numbers studies indicated that a variety of dietary compounds such as curcumin, green tea, folat, selenium, and soy isoflavones show a wide range anti-cancer properties. It has been showed that these compounds via targeting a sequence of cellular and molecular pathways could be used as suitable options for cancer chemoprevention and cancer therapy. Recently, dietary microRNAs and exosomes have been emerged as attractive players in cancer prevention and cancer therapy. These molecules could change behavior of cancer cells via targeting various cellular and molecular pathways involved in cancer pathogenesis. Hence, the utilization of dietary compounds which are associated with powerful molecules such as microRNAs and exosomes and put them in dietary patterns could contribute to prevention or treatment of various cancers. Here, we summarized various studies that assessed effect of dietary patterns on cancer prevention shortly. Moreover, we highlighted the utilization of dietary compounds, dietary microRNAs, and dietary exosomes and their cellular and molecular pathways in cancer chemoprevention. © 2017 Wiley Periodicals, Inc