Transforming User Experience Design Education Through Integrated Learning

Short Abstract: We introduce the program design of a new studio-based undergraduate program in User Experience (UX) Design. The program includes several curricular innovations, such as an integrated studio pedagogy in which six topical strands are interwoven across two types of studios, spanning five semesters of the undergraduate experience. Full Abstract: The rapid growth of the UX design profession has led to an increased need for qualified practitioners and a proliferation of UX educational programs offered in both academia and industry. In this presentation, we introduce the program design of a new studio-based undergraduate program in UX—the first of its kind at a large, research-intensive US university. The program includes several curricular innovations, such as an integrated studio pedagogy in which six topical strands are interwoven across two types of studios. These studios are interconnected and span five semesters of the undergraduate experience. We present the curriculum model and the foundational principles that informed its design. We describe the two types of studios and their interconnection, and present early evaluation data showing that students are building valuable skills

Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

INTRODUCTION: A major pathophysiologic mechanism in sepsis is impaired host immunity which results in failure to eradicate invading pathogens and increased susceptibility to secondary infections. Although many immunosuppressive mechanisms exist, increased expression of the inhibitory receptor programmed cell death 1 (PD-1) and its ligand (PD-L1) are thought to play key roles. The newly recognized phenomenon of T cell exhaustion is mediated in part by PD-1 effects on T cells. This study tested the ability of anti-PD-1 and anti-PD-L1 antibodies to prevent apoptosis and improve lymphocyte function in septic patients. METHODS: Blood was obtained from 43 septic and 15 non-septic critically-ill patients. Effects of anti-PD-1, anti-PD-L1, or isotype-control antibody on lymphocyte apoptosis and interferon gamma (IFN-γ) and interleukin-2 (IL-2) production were quantitated by flow cytometry. RESULTS: Lymphocytes from septic patients produced decreased IFN-γ and IL-2 and had increased CD8 T cell expression of PD-1 and decreased PD-L1 expression compared to non-septic patients (P<0.05). Monocytes from septic patients had increased PD-L1 and decreased HLA-DR expression compared to non-septic patients (P<0.01). CD8 T cell expression of PD-1 increased over time in ICU as PD-L1, IFN-γ, and IL2 decreased. In addition, donors with the highest CD8 PD-1 expression together with the lowest CD8 PD-L1 expression also had lower levels of HLA-DR expression in monocytes, and an increased rate of secondary infections, suggestive of a more immune exhausted phenotype. Treatment of cells from septic patients with anti-PD-1 or anti-PD-L1 antibody decreased apoptosis and increased IFN-γ and IL-2 production in septic patients; (P<0.01). The percentage of CD4 T cells that were PD-1 positive correlated with the degree of cellular apoptosis (P<0.01). CONCLUSIONS: In vitro blockade of the PD-1:PD-L1 pathway decreases apoptosis and improves immune cell function in septic patients. The current results together with multiple positive studies of anti-PD-1 and anti-PD-L1 in animal models of bacterial and fungal infections and the relative safety profile of anti-PD-1/anti-PD-L1 in human oncology trials to date strongly support the initiation of clinical trials testing these antibodies in sepsis, a disorder with a high mortality

Design Strategy for the Development of Applications for Autism Instruction

This paper explains my journey of exploration into the development of a mobile application for children with Autism Spectrum Disorders (ASD) based on researching an area of instructional need. The direction spread to creating a tool to encourage collaboration between designers and educators to generate more mobile application educational opportunities for children with ASD. These two paths of development of touch screen mobile computer (TSMC) applications are explored in this paper. The first path of application development, based on a researched instructional need into improving the comprehension skills of children with ASD by teaching the emergent literacy skill of vocabulary with labels, is shown with the development of Literacy Labels. The second path is to develop an application based on a direct instructional approach that is being used with children with ASD that would benefit from automation in a mobile application. For this second path, the creation of the Definition Outline for Collaboration (DOC) is detailed. This path is for teachers, clinicians, therapists, parents, and/or those in the research community to document a possible design idea as a catalyst for collaboration with the design community. The most effective application design for children with autism must start with an understanding of the user\u27s unique instructional needs and both of these paths start with this strong foundation