Breast cancer prevention in women treated at Primary Care Unit

Objective: to describe the profile of women treated at Primary Care Unit and identify the attitudes toward early detection of breast cancer. Methods: exploratory and descriptive research conducted with 40 women aged over 20 years, after nursing consultation. Results: it was verified that a share of participants presented risk factors for breast cancer, especially menarche before age 12, 57% (n=23); no breast examination during the consultation, 70% (n=28); and never have done breast examination, 57.5% (n=23). As for performing the self-examination, 80% (n=32) of women said they knew how to do it, of which 65.5% reported performing it monthly, 12.5% ​​never did it, and 23% of women over 40 years did not undergo mammography. Conclusion: we highlight the need to develop effective educational interventions addressing the risk factors and early detection of breast cancer in the health services

Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines

Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into account the antitumor activity of biflorin, a substance isolated from Capraria biflora L roots that is cytotoxic in vitro and in vivo, this study aimed to demonstrate the action of biflorin against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of genetic alterations and mutations, such as the TP53, NRAS and BRAF genes. The results presented here indicate that biflorin reduces the viability of melanoma cell lines by DNA interactions. Biflorin causes single and double DNA strand breaks, consequently inhibiting cell cycle progression, replication and DNA repair and promoting apoptosis. Our data suggest that biflorin could be considered as a future therapeutic option for managing melanoma. (C) 2016 Elsevier Ltd. All rights reserved.FAPEAMCNPqFed Univ Amazon, Pharmaceut Sci, Av Gen Rodrigo Octavio 6200, BR-69077000 Manaus, Amazonas, BrazilUniv Fed Amazonas, Fac Ciencias Farmaceut, Rua Alexandre Amorim 330, BR-69010300 Manaus, Amazonas, BrazilFed Univ Para, Oncol Res Ctr, BR-66059 Belem, Para, BrazilHosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, Av Mundurucus 4487, BR-66073000 Belem, Para, BrazilUniv Fed Ceara, Dept Organ & Inorgan Chem, Fortaleza, Ceara, BrazilUniv Fed Sao Paulo, Div Genet, Rua Botucatu 740, BR-04023062 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, Rua Botucatu 740, BR-04023062 Sao Paulo, SP, BrazilFed Univ Amazon, Pharmaceut Sci, Av Gen Rodrigo Octavio 6200, BR-69077000 Manaus, Amazonas, BrazilUniv Fed Amazonas, Fac Ciencias Farmaceut, Av Gen Rodrigo Octavio 6200,Coroado 1, BR-69077000 Manaus, Amazonas, BrazilUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol & Genet, Rua Botucatu 740, BR-04023062 Sao Paulo, SP, BrazilFAPEAM: N.020/2013CNPq: 485433/2012-5Web of Scienc

Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial

Background: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P <.01), mainly due to a 0.5-serving/d greater intake of fruits and of vegetables in the BALANCE group. Primary end point events occurred in 236 participants (18.8%) in the BALANCE group and in 207 participants (16.4%) in the control group (hazard ratio, 1.15; 95% CI 0.95-1.38; P =.15). Secondary end points did not differ between groups after follow-up. Conclusions: The BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD and had no significant effect on the incidence of cardiovascular events or death. © 2019 The Author