1,387 research outputs found
A Dodecalogue of Basic Didactics from Applications of Abstract Differential Geometry to Quantum Gravity
We summarize the twelve most important in our view novel concepts that have
arisen, based on results that have been obtained, from various applications of
Abstract Differential Geometry (ADG) to Quantum Gravity (QG). The present
document may be used as a concise, yet informal, discursive and peripatetic
conceptual guide-cum-terminological glossary to the voluminous technical
research literature on the subject. In a bonus section at the end, we dwell on
the significance of introducing new conceptual terminology in future QG
research by means of `poetic language'Comment: 16 pages, preliminary versio
An Evaluated Certification Services System for the German National Root CA - Legally Binding and Trustworthy Transactions in E-Business and E-Government
National Root CAs enable legally binding E-Business and E-Government
transactions. This is a report about the development, the evaluation and the
certification of the new certification services system for the German National
Root CA. We illustrate why a new certification services system was necessary,
and which requirements to the new system existed. Then we derive the tasks to
be done from the mentioned requirements. After that we introduce the initial
situation at the beginning of the project. We report about the very process and
talk about some unfamiliar situations, special approaches and remarkable
experiences. Finally we present the ready IT system and its impact to
E-Business and E-Government.Comment: 6 pages; 1 figure; IEEE style; final versio
3D Printing Provides a Precise Approach in the Treatment of Tetralogy of Fallot, Pulmonary Atresia with Major Aortopulmonary Collateral Arteries.
Patients with tetralogy of Fallot, pulmonary atresia, and multiple aortopulmonary collateral arteries (Tet PA MAPCAs) have a wide spectrum of anatomy and disease severity. Management of these patients can be challenging and often require multiple high-risk surgical and interventional catheterization procedures. These interventions are made challenging by complex anatomy that require the proceduralist to mentally reconstruct three-dimensional anatomic relationships from two-dimensional images. Three-dimensional (3D) printing is an emerging medical technology that provides added benefits in the management of patients with Tet PA MAPCAs. When used in combination with current diagnostic modalities and procedures, 3D printing provides a precise approach to the management of these challenging, high-risk patients. Specifically, 3D printing enables detailed surgical and interventional planning prior to the procedure, which may improve procedural outcomes, decrease complications, and reduce procedure-related radiation dose and contrast load
Loop quantum black hole
In this paper we consider the Kantowski-Sachs space-time in Ashtekar
variables and the quantization of this space-time starting from the complete
loop quantum gravity theory. The Kanthowski-Sachs space-time coincides with the
Schwarzschild black hole solution inside the horizon. By studying this model we
can obtain information about the black hole singularity and about the dynamics
across the point r=0. We studied this space-time in ADM variables in two
previous papers where we showed that the classical black hole singularity
disappears in quantum theory. In this work we study the same model in Ashtekar
variables and we obtain a regular space-time inside the horizon region and that
the dynamics can be extend further the classical singularity.Comment: 12 pages, latex. We introduce and we calculate the spectrum of the
operator 1/|E
Design Details to Accommodate Fault Movement in a Dam Foundation
During planning for dam projects, good practice usually calls for appropriate investigations to help assure the development is not located on or immediately adjacent to active faults. There are examples of projects, however, where an active fault has been discovered in or close to a dam foundation and engineering solutions have been incorporated into design to enable satisfactory performance of the dam should fault displacement occur during project operation. In some cases, the existence of such hazards only becomes evident late in the design cycle when the dam site is considered fixed and hazard avoidance is not an easy option. The 960-MW Neelum-Jhelum Hydroelectric Project in Pakistan is being constructed within a geologically complex and seismo-tectonically active setting. During feasibility studies, a major thrust fault at the dam site was deemed inactive. However, during detailed design and after commitment to start construction with international contractors, the potentially active nature of the fault came to be understood. The dam is re-designed as a composite structure, with a zoned fill section overlying the fault and the remainder of the dam consisting of a concrete gravity feature with integral gated spillway. The fill section designed to accommodate the maximum amount of offset that could occur on the fault below. This concept has been adopted on other projects elsewhere, such as the approach dams leading to the new Pacific Locks Complex, which are intersected by segments of the active Pedro Miguel fault for the new Third Set of Locks of the Panama Canal. During construction of the Neelum-Jhelum dam, the actual fault trace was found unfortunately to be not entirely beneath the fill section and that some of the concrete super-structure would overlie the fault. Innovative subsurface foundation treatments have been developed to help direct any potential future fault movement into the fill and away from the concrete part of the dam. This paper describes these measures and the analytical methods used in design development
Hypertension and other morbidities with Cushing’s syndrome associated with corticosteroids: a review
Corticosteroids constitute an ideal treatment for various inflammatory and autoimmune disorders due to their anti-inflammatory and immunomodulatory actions. However, corticosteroids have a considerable number of side effects, including hypertension, diabetes, lipid disorders, sleep apnea, osteoporosis, myopathy, and disorders of coagulation and fibrinolysis, which are components of Cushing’s syndrome (CS). Corticosteroid-induced side effects are dependent on the formulation, route, dose, and time of exposure. However, the underlying pathogenetic mechanisms have not been clearly defined. A large body of evidence supports the role of an imbalance between vasoconstriction and vasodilation with possible links to nitric oxide, prostanoids, angiotensin II, arginine vasopressin, endothelins, catecholamines, neuropeptide Y, and atrial natriuretic peptide. Increased oxidative stress, renin–angiotensin system activation, increased pressor response, metabolic syndrome, and sleep apnea appear to be pathogenetically involved as well. The ideal treatment is the withdrawal of corticosteroids, which is most often impossible due to the exacerbation of the underlying disease. Alternatively, a careful plan, including the proper selection of the formulation, time, and route, should be made, and each side effect should be treated properly. The focus of the research should be to develop synthetic corticosteroids with anti-inflammatory effects but fewer metabolic effects, which so far has been unsuccessful
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