New constraints on supersymmetry using neutrino telescopes

We demonstrate that megaton-mass neutrino telescopes are able to observe the signal from long-lived particles beyond the Standard Model, in particular the stau, the supersymmetric partner of the tau lepton. Its signature is an excess of charged particle tracks with horizontal arrival directions and energy deposits between 0.1 and 1 TeV inside the detector. We exploit this previously-overlooked signature to search for stau particles in the publicly available IceCube data. The data shows no evidence of physics beyond the Standard Model. We derive a new lower limit on the stau mass of 320 GeV (95% C.L.) and estimate that this new approach, when applied to the full data set available to the IceCube collaboration, will reach word-leading sensitivity to the stau mass (m_{\tilde{t}} = 450GeV)

Vascular Dysfunction in Preeclampsia

Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preeclampsia, both maternal and placental vascular dysfunction plays a role in the pathogenesis and can persist into the postpartum period. Potential abnormalities include impaired placentation, incomplete spiral artery remodeling, and endothelial damage, which are further propagated by immune factors, mitochondrial stress, and an imbalance of pro- and antiangiogenic substances. While the field has progressed, current gaps in knowledge include detailed initial molecular mechanisms and effective treatment options. Newfound evidence indicates that vasopressin is an early mediator and biomarker of the disorder, and promising future therapeutic avenues include mitigating mitochondrial dysfunction, excess oxidative stress, and the resulting inflammatory state. In this review, we provide a detailed overview of vascular defects present during preeclampsia and connect well-established notions to newer discoveries at the molecular, cellular, and whole-organism levels

Handcycling with concurrent lower body low-frequency electromyostimulation increases acute oxygen uptake in elite wheelchair basketball players: An acute crossover trial.

Micke F, Rappelt L, Held S, Wiedenmann T, Kleinöder H, Donath L. Handcycling with concurrent lower body low-frequency electromyostimulation increases acute oxygen uptake in elite wheelchair basketball players: An acute crossover trial. In: Guilhem G, Rabita G, Brocherie F, et al., eds. Book of Abstracts of the 28 th Annual Congress of the European College of Sport Science. 2023: 756

Benefits of neurohormonal therapy in patients with continuous-flow left ventricular assist devices

Left ventricular assist devices (LVADs) have dramatically improved short-term outcomes among patients with advanced heart failure. While neurohormonal blockade (NHB) is the cornerstone of treatment for patients with heart failure with reduced ejection fraction, its effect after LVAD placement has not been established. We reviewed medical records of 307 patients who underwent primary LVAD implantation from January 2006 to September 2015 at two institutions in the United States. Patients were followed for at least 2 years post-LVAD implantation or until explantation, heart transplantation, or death. Cox regression analysis stratifying on center was used to assess associations with mortality. Neurohormonal blockade use was treated as a time-dependent predictor. Stepwise selection indicated treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEIs/ARBs) (hazard ratio [HR] = 0.53 [0.30-0.95], p = 0.03), age at the time of implantation (HR = 1.28 [1.05-1.56] per decade, p = 0.02), length of stay postimplantation (HR = 1.16 [1.11-1.21] per week, p \u3c 0.01) and INTERMACS profile of 1 or 2 (HR = 1.86 [1.17-2.97], p \u3c 0.01) were independent predictors of mortality. In this large, retrospective study, treatment with ACEIs or ARBs was an independent factor associated with decreased mortality post-LVAD placement