Identification and characterization of methotrexate photodegradation products

International audienc

Self-Immolative Spacers: Kinetic Aspects, Structure-Property Relationships, and Applications

International audienc

A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations

International audienceSpatiotemporal control of molecular distribution is much in demand in many fields of chemistry. To address this goal, we exploit a low molecular weight branched self-immolative architecture, which acts as a triggerable chemically encoded timer for autonomous sequential release of two chemicals. Using a light-activated model liberating two distinct fluorophores, we generated a tunable spatially contrasted molecular distribution

A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations

International audienceSpatiotemporal control of molecular distribution is much in demand in many fields of chemistry. To address this goal, we exploit a low molecular weight branched self-immolative architecture, which acts as a triggerable chemically encoded timer for autonomous sequential release of two chemicals. Using a light-activated model liberating two distinct fluorophores, we generated a tunable spatially contrasted molecular distribution

Disassembly Kinetics of Quinone-Methide-Based Self-Immolative Spacers that Contain Aromatic Nitrogen Heterocycles

International audienc

Spermine-NBD as fluorescent probe for studies of the polyamine transport system in Leishmania donovani

International audienceThis study describes the synthesis of fluorescent probes as potential substrates for the polyamine transport system (PTS) of Leishmania donovani. A competitive radioassay was used to determine the most efficient probe. We observed that the conjugate spermine-nitrobenzofurazan (Spm-NBD) was able to compete with [3H]-spermidine in L. donovani at a potent IC50 of 60 µM

Light Activation for the Versatile and Accurate Kinetic Analysis of Disassembly of Self-Immolative Spacers

International audienc

Novel dipeptide compounds, method for the production thereof and a novel therapeutic use of dipeptide compounds

The invention relates to a novel therapeutic use of dipeptide compounds having formula (I). The dipeptide compounds are useful as inhibitors of beta-lactamases, in particular belonging to the class of carbapenemases. The invention also relates to novel dipeptide compounds