Life cycle assessment of photovoltaic implementation: an Italian case study

The energy efficiency is the possibility and ability to carry out a production process consume with the involves of less energy and minor environmental impact. Life Cycle Assessment is one of the major tools involved in the economic, social and environmental evaluation. The aim of this work is the LCA application to an Italian company that provides to install a photovoltaic plant for the energy self-maintenance, in order to break down costs and environmental impacts. The photovoltaic business can be an interesting solution especially for companies which consume more energy during the day. In the case study was highlighted that an average of 400.00 €/month was spent, equal to about 900 kWh / month. The company installed a 10 kWp photovoltaic system and with this implementation the energy consumption diminished of 84% and the costs of 57%

Filiera della canapa industriale (Cannabis sativa L.): sfide e nuove opportunità

La Cannabis Sativa è una pianta utilizzata in maniera sempre maggiore in diverse filiere del mercato: agro- alimentare, tessile, edile, cosmetico e della chimica verde, sostituendo prodotti "classici" con nuovi prodotti più performanti dal punto di vista ambientale e tecnologico. La "canapa industriale" ha un contenuto in tetraidriocannabinolo (THC) inferiore allo 0,2%, che ne permette la coltivazione e la commercializzazione in Europa (Reg. CE n.1673/2000 e Reg. CE n.73/2009). Ampiamente coltivata in Italia e nel mondo fino alla metà del secolo scorso, principalmente per ottenerne prodotti da impiegare nell'industria tessile, motivazioni economiche e politiche (Legge 22/12/1975 n.685) ne hanno segnato il declino. Oggi comunque questa coltura sta conoscendo un nuovo periodo di espansione per le caratteristiche e i molteplici usi che la rendono particolarmente vicina ai principi della green economy. In Europa la superficie coltivata ha raggiunto il valore di circa 25.000 ha nel 2016, in crescita del 37% rispetto al 2014. Il ritorno della canapicoltura sta avvenendo su basi completamente diverse rispetto al passato, quando l'unico prodotto vendibile era la fibra lunga, per la creazione di tessuti e cordami, ottenuta attraverso procedimenti che richiedevano enormi impieghi di manodopera. Oggi, dal punto di vista delle possibilità d'impiego, la canapa presenta caratteristiche di versatilità che rendono questa materia prima utilizzabile in molti settori per le sue proprietà: produzione di carta (la canapa ha una resa in polpa per ettaro 4 volte superiore rispetto al legno, oltre a richiedere 1/7 del quantitativo di solventi chimici), industria chimica, industria alimentare (attraverso l'impiego di olio e farine ricavate dai semi della canapa) e produzione di energia pulita. Inoltre è importante ricordare la capacità fitodepuratrice della canapa (già sfruttata nel nostro Paese per il recupero dell'area industriale di Porto Marghera nel Veneziano). Le radici fittonanti riescono a raggiungere profondità maggiori rispetto ad altre piante a rapido accrescimento, inoltre gli inquinanti vengono accumulati in foglie e semi, permettendo un utilizzo sicuro della fibra. Dunque la canapa, pur essendo una coltura tradizionale, ben si presta a molteplici utilizzazioni innovative, che la identificano come una delle colture erbacee più promettenti nello scenario agricolo internazionale. Il presente lavoro ha l'obiettivo di analizzare il mercato e le potenzialità di crescita della canapa nei differenti settori, tenendo in considerazione anche le iniziative finalizzate a promuovere e sostenere, sul territorio, un modello di sviluppo diffuso fondato sulla valorizzazione delle risorse presenti a livello locale e, quindi, sull'integrazione delle diverse attività economiche potenzialmente interessate all'impiego della canapa

Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition

The standard front-line treatment for pleural mesothelioma (PM) is pemetrexed-based chemotherapy, whose major target is thymidylate synthase (TS). In several cancer models, miR-215 and miR-375 have been shown to target TS, while information on these miRNAs in PM are still limited although suggest their role in epithelial to mesenchymal transition. Seventy-one consecutive PM tissues (4 biphasic, 7 sarcomatoid, and 60 epithelioid types) and 16 commercial and patient-derived PM cell lines were screened for TS, miR-215, and miR-375 expression. REN and 570B cells were selected for miR-215 and miR-375 transient transfections to test TS modulation. ZEB1 protein expression in tumor samples was also tested. Moreover, genetic profile was investigated by means of BAP1 and p53 immunohistochemistry. Expression of both miR-215 and miR-375 was significantly higher in epithelioid histotype. Furthermore, inverse correlation between TS protein and both miR-215 and miR-375 expression was found. Efficiently transfected REN and 570B cell lines overexpressing miR-215 and miR-375 showed decreased TS protein levels. Epithelioid PM with a mesenchymal component highlighted by reticulin stain showed significantly higher TS and ZEB1 protein and lower miRNA expression. A better survival was recorded for BAP1 lost/TS low cases. Our data indicate that miR-215 and miR-375 are involved in TS regulation as well as in epithelial-to-mesenchymal transition in PM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00428-022-03321-8

ACTH-producing tumorlets and carcinoids of the lung: clinico-pathologic study of 63 cases and review of the literature.

Adrenocorticotropic hormone (ACTH)-secreting lung carcinoids represent the principal cause of ectopic Cushing syndrome, but the prevalence of ACTH expression and the association between ACTH production and Cushing syndrome in lung carcinoids have scarcely been investigated. In addition, available information on the prognostic meaning of ACTH production is controversial. The aims of this multicentric retrospective study, also including a review of the literature, were to describe the clinico-pathologic features of ACTH-producing lung carcinoids, to assess recurrence and specific survival rates, and to evaluate potential prognostic factors. To identify ACTH production in 254 unselected and radically resected lung carcinoids, we used a double approach including RT-PCR (mRNA encoding for pro-opiomelanocortin) and immunohistochemistry (antibodies against ACTH and β-endorphin). Sixty-three (24.8%) tumors produced ACTH and 11 of them (17.4%), representing 4.3% of the whole series, were associated with Cushing syndrome. The median follow-up time was 71 months. The 10-year overall and specific survival rates were 88.5% and 98.2%, respectively, with difference neither between functioning and nonfunctioning tumors nor between ACTH-positive and ACTH-negative carcinoids. At univariate analysis, histological type (typical or atypical) and Ki67 index significantly correlated with tumor recurrence. The literature review identified 172 previously reported patients with functioning ACTH-secreting lung carcinoids, and the meta-analysis of survival showed that 92% of them were alive after a mean follow-up time of 50 months. Our results demonstrate that ACTH-producing lung carcinoids are not rare, are not always associated with Cushing syndrome, and do not represent an aggressive variant of lung carcinoid

Cannabis sativa L. inflorescences from monoecious cultivars grown in central Italy: an untargeted chemical characterization from early flowering to ripening

The chemical composition of the inflorescences from four Cannabis sativa L. monoecious cultivars (Ferimon, Uso-31, Felina 32 and Fedora 17), recently introduced in the Lazio Region, was monitored over the season from June to September giving indications on their sensorial, pharmaceutical/nutraceutical proprieties. Both untargeted (NMR) and targeted (GC/MS, UHPLC, HPLC-PDA/FD and spectrophotometry) analyses were carried out to identify and quantify compounds of different classes (sugars, organic acids, amino acids, cannabinoids, terpenoids, phenols, tannins, flavonoids and biogenic amines). All cultivars in each harvesting period showed a THC content below the Italian legal limit, although in general THC content increased over the season. Citric acid, malic acid and glucose showed the highest content in the late flowering period, whereas the content of proline drastically decreased after June in all cultivars. Neophytadiene, nerolidol and chlorogenic acid were quantified only in Felina 32 cultivar, characterized also by a very high content of flavonoids, whereas alloaromadendrene and trans-cinnamic acid were detected only in Uso-31 cultivar. Naringenin and naringin were present only in Fedora 17 and Ferimon cultivars, respectively. Moreover, Ferimon had the highest concentration of biogenic amines, especially in July and August. Cadaverine was present in all cultivars but only in September. These results suggest that the chemical composition of Cannabis sativa L. inflorescences depends on the cultivar and on the harvesting period. Producers can use this information as a guide to obtain inflorescences with peculiar chemical characteristics according to the specific use

Acquisition of a Unique Onshore/Offshore Geophysical and Geochemical Dataset in the Northern Malawi (Nyasa) Rift

The Study of Extension and maGmatism in Malawi aNd Tanzania (SEGMeNT) project acquired a comprehensive suite of geophysical and geochemical datasets across the northern Malawi (Nyasa) rift in the East Africa rift system. Onshore/offshore active and passive seismic data, long‐period and wideband magnetotelluric data, continuous Global Positioning System data, and geochemical samples were acquired between 2012 and 2016. This combination of data is intended to elucidate the sedimentary, crustal, and upper‐mantle architecture of the rift, patterns of active deformation, and the origin and age of rift‐related magmatism. A unique component of our program was the acquisition of seismic data in Lake Malawi, including seismic reflection, onshore/offshore wide‐angle seismic reflection/refraction, and broadband seismic data from lake‐bottom seismometers, a towed streamer, and a large towed air‐gun source