10 research outputs found
Is there a close association between "soils" and "vegetation"? : A case study from central western New South Wales
- Publication venue
- Publication date
- 01/01/2007
- Field of study
The assumption that ‘soils’ and ‘vegetation’ are closely associated was tested by describing soils and vegetation along a Travelling Stock Reserve west of Grenfell, New South Wales (lat 33° 55’S, long 147° 45’E). The transect was selected on the basis of (a) minimising the effects of non-soil factors (human interference, climate and relief) on vegetation and (b) the presence of various soil and vegetation types as indicated by previous mapping. ‘Soils’ were considered at three levels: soil landscapes (a broad mapping unit widely used in central western NSW), soil types (according to a range of classifications) and soil properties (depth, pH, etc.). ‘Vegetation’ was considered in three ways: vegetation type (in various classifications), density/floristic indices (density of woody species, abundance of native species, etc.) and presence/absence of individual species. Sites along the transect were grouped according to soil landscapes or soil types and compared to vegetation types or indices recorded at the sites. Various measures indicated low associations between vegetation types and soil landscapes or soil types. Except for infrequent occurrences of a soil type or landscape, any one soil type or landscape was commonly associated with a number of vegetation types and any one vegetation type was associated with a number of soil landscapes or soil types. However, significant associations between some vegetation indices, mainly density or numbers of woody species, and some soil landscapes and soil types were evident. Although many species were relatively ubiquitous, some groups of species that were restricted to one or two soil types were identified. Canonical Correspondence Analysis provided some suggestions as to which properties (e.g. texture) of these soils were associated with the presence of particular species
Four rural cemeteries in central western NSW: Islands of Australiana in a European sea?
- Publication venue
- Publication date
- 19/04/2013
- Field of study
Vascular plants present in groundstoreys of variously–managed areas in four cemeteries in central western NSW – two on the Central Western Slopes (Garra and Toogong) and two on the Central Tablelands (Lyndhurst and Carcoar) – were recorded over periods of 6–10 years. It was hypothesised that (a) areas of the cemeteries with a history of nil or low disturbance would represent high quality remnant vegetation (i.e. contain a diversity of native species but few naturalised species), and (b) that clearing of woody vegetation, together with similar management (e.g. regular mowing) would result in homogenisation of the groundstoreys such that many species, native and naturalised, would be common to all sites. 344 species (176 native, 154 naturalised and 14 non–naturalised exotics) were recorded across the four cemeteries. Many native species that were rare in the surrounding agricultural lands were present in the cemeteries (enhancing their value as conservation areas) but no cemetery contained areas of groundstorey that would qualify as ‘pristine’. Across all management areas, the proportions of naturalised species in the native + naturalised floras of the cemeteries ranged from 46 to 55 %. Though never dominant, naturalised species also comprised high proportions (42 to 51 %) of the floras of the least disturbed (nil or infrequently mown) areas within each cemetery. Many (40 %) of the species recorded occurred at only one cemetery. This partly explained why the floras of similarly– managed parts of cemeteries on the Central Western Slopes were, contrary to expectations, markedly different to those on the Central Tablelands. However, within the same botanic subdivision, floras – particularly of naturalised species in regularly mown grasslands – were more similar (‘homogenised’) than those of nil or infrequently mown grasslands
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- Mérida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson Siân M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-Carrascón Víctor
- Cesareni Gianni
- Cha John
- Cha John
- Cha John
- Champion Brian
- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
- Chang Alfred E
- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
- Conwell Darwin
- Corrales Leticia P
- Corrales Leticia P
- Coukos George
- Coukos George
- Coussens Lisa M
- Coussens Lisa M
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R
- Cronstein Bruce N
- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
- Diab Adi
- Diab Adi
- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J
- Dietz Allan B
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
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- Squalls Olivia
- Srirangam Jay
- Srivastava Raghvendra
- Staab Mary J
- Stack Edward
- Staelens Ludovicus
- Starzynska Teresa
- Steadman Lora
- Steadman Lora
- Stefano Pierini
- Stefano Pierini
- Stefano Pierini
- Steggerda Susanne
- Stein Paul L
- Stelow Edward B
- Sternby Malin
- SternJohn Julius
- Stewart Al
- Stock Wendy
- Stone Geoffrey W
- Stosnach Claudia
- Straub Tobias
- Straus Jane
- Streiner Nicole
- Ståhle Magnus
- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
- Sukari Ammar
- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
- Suryawanshi Satyendra
- Suzuki Akiko
- Suzuki Ryuji
- Sweis Randy F
- Taback Bret
- Tagliaferri Mary
- Talbert Erin
- Tallarico John
- Tan Joanne B
- Tan Joanne B L
- Tan Wei
- Tan Yann C
- Tanaka Maki
- Tang Chad
- Tannir Nizar M
- Tannir Nizar M
- Taylor Allison
- Taylor Matthew
- Tcherepanova Irina
- ter Meulen Jan
- ter Meulen Jan
- Terabe Masaki
- Terabe Masaki
- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A
- Thounaojam Menaka
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A
- Tipton Kimberly A
- Tognon Christina E
- Tomai Mark A
- Toms Anne
- Torno Sebold
- Torrey Heather
- Torti Vince
- Toth Laszlo
- Trager James B
- Trappey Alfred F
- Trivedi Sumita
- Truesdell Peter
- Tsang Kwong
- Tsang Kwong
- Tsang Kwong Y
- Tsaparikos Konstantinos
- Tsouko Efrosini
- Tsujikawa Takahiro
- Tsujikawa Takahiro
- Tsujikawa Takahiro
- Tuck David
- Tumang Joseph
- Tumang Joseph
- Turbitt William J
- Turk Andrew T
- Tyner Jeffery W
- Tähtinen Siri
- Tähtinen Siri
- Uecker Darrin
- Uecker Darrin
- Uecker Darrin
- Ugel Stefano
- Ugel Stefano
- Uhlik Mark
- Ujhelyi Mihaly
- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Urban Julie
- Valsesia-Wittmann Sandrine
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E
- Vignali Dario
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
- vonEbyen Rie
- Vreeland Timothy J
- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B
- Wang Ena
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K
- Wang Yi
- Wang Ziming
- Ward Stephen T
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R
- Weiner David
- Weiner Louis M
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Wenthe Jessica
- Werner Lauryn R
- West Brian
- West James
- West James
- Wheatley Courtney
- Whetstone Ryan
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C
- Whiting Chan C
- Wicha Max S
- Wicha Max S
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W
- Wilkinson Robert W
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Chihunt
- Wong Deborah J
- Wong Gabriel
- Wong Kenneth R
- Wong Kenneth R
- Wong Michael K
- Wood Laura
- Woodside Darren G
- Workman Creg
- Wu Bill X
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Ylösmäki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Hermeneutic retrieval and the conflict of styles in Pirandello's Sei Personaggi in Cerca D'Autore
- Author
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- Anthony Petruzzi
- Ascoli Albert Russell
- Bakhtin M. M.
- Barthes Roland
- Birault Henri
- Bishop Thomas
- Bové Paul A.
- Carrabino Victor
- Cincotta Madeleine
- Dombroski Robert S.
- Edie James N.
- Enkvist Nils Erik
- Fisher James
- Flannery Kathryn T.
- Gadamer Hans‐Georg
- Grondin Jean
- Guignon Charles
- Harr Michel
- Heidegger Martin
- Hyde Michael J.
- Jaeger Hans
- Jameson Fredric
- Lukács George
- McDonald David
- Milic Louis T.
- Nagy Moses M.
- Ohmann Richard
- Paolucci Anne
- Pirandello Luigi
- Plato
- Pratt Mary Louise
- Ragusa Olga
- Rankin Elizabeth D.
- Schrag Calvin O.
- Spanos William V.
- Starkie Walter
- Storer Edward
- Sypher Wylie
- Tillich Paul
- Vattimo Gianni
- Williams Patricia
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Cumulative Index
- Author
- Adams Eleanor K.
- Adams Eleanor K.
- Baar Carl
- Baar Ellen
- Bellas Carl J.
- Berkson Larry
- Blumstein Alfred
- Bond James F.
- Brenner Saul
- Canon Bradley C.
- Carlson Alan
- Carlson Norman A.
- Carp Robert A.
- Carp Robert A.
- Catlin Dennis W.
- Cohen Fred
- Cole George
- Cole George F.
- Crohn Madeleine
- Davis Charles E.
- Davis Robert C.
- Dubois Philip L.
- Dunham Roger G.
- Edelstein Charles D.
- Feeney Floyd
- Fenster Carol
- Flanders Steven
- Flanders Steven
- Flango Victor E.
- Gallas Geoff
- Gibbs John J.
- Gilmore Horace W.
- Goldman Jerry
- Gordon Simeon E.
- Hall Melinda Gann
- Heumann Milton
- Horvitz Jerome S.
- Jackson David M.
- Johnston Dan L.
- Jones Juanita
- Juillard Joelle R.
- Kahalas Harvey
- Kahalas Harvey
- Katz Jonathan
- Krislov Samuel
- Kutscher Robert I.
- Land Frank P.
- Lawson Harry O.
- Lawson Harry O.
- Leidinger Jeffrey W.
- Lichtenstein Michael J.
- Mahoney Anne Rankin
- Martin Merle P.
- Mathews M. Cash
- McDermott John T.
- McDermott John T.
- McDonald Y. Graham
- McEwen Craig A.
- Meador Daniel
- Metrick Dennis L.
- Miller Neal
- Milner Neal
- Morgan Dennis E.
- Nejelski Paul
- Nejelski Paul
- Nelson Robert L.
- Niesewand Peter
- Plank Leonard E.
- Polansky Larry
- Puro Steven
- Quinn Robert
- Robinson James W.
- Rosen Lawrence
- Rosenberg Maurice
- Saari David J.
- Saari David J.
- Saari David J.
- Scott I. R.
- Shannon Charles P.
- Shannon Charles P.
- Silberman Charles
- Silbert Jonathan
- Stauber Alvin
- Stern Duke Nordlinger
- Stie John
- Stout Ronald M.
- Sundeen Richard A.
- Tobin Robert W.
- Tucker Edwin W.
- Tucker Edwin W.
- Walker Kenneth E.
- Ward David A.
- Wasby Stephen L.
- Weeks Kent M.
- Weinstein David
- Weller Steven
- Wheeler Russell R.
- Wheeler Russell R.
- Wice Paul B.
- Wice Paul B.
- Wolf Jo Beth
- Woodward James G.
- Zaffarano Mark A.
- Zemans Frances Kahn
- Zemans Frances Kahn
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
The Justice System Journal Cumulative Index
- Author
- Adams Eleanor K.
- Adams Eleanor K.
- Adams Stuart N.
- Anderson David P.
- Bellas Carl J.
- Berkson Larry
- Bond James E.
- Brenner Saul
- Broccolina Frank
- Burger Warren E.
- Canon Bradley C.
- Carlson Alan
- Carlson Norman A.
- Carp Robert A.
- Carp Robert A.
- Carver John
- Catlin Dennis W.
- Cohen Fred
- Cole George F.
- Cole George F.
- Crohn Madeleine
- Cummings Laird
- Davis Charles E.
- Davis Robert C.
- Dubois Philip L.
- Dunham Roger G.
- Edelstein Charles D.
- Feeney Floyd
- Fenster Carol
- Flanders Steven
- Flanders Steven
- Flango Victor E.
- Flango Victor E.
- Gallas Geoff
- Garofalo James
- Gibbs John J.
- Goldman Jerry
- Gordon Simeon E.
- Hall Melinda Gann
- Heumann Milton
- Horvitz Jerome S.
- Hoskins Ronald B.
- Jackson David M.
- Johnston Dan L.
- Jones Juanita B.
- Jones Peter R.
- Juillard Joelle R.
- Kahalas Harvey
- Kahalas Harvey
- Katz Jonathan
- Krislov Samuel
- Kutscher Robert I.
- Land Frank P.
- Lawson Harry O.
- Leidinger Jeffrey W.
- Lichtenstein Michael J.
- Luskin Mary Lee
- Mahoney Anne Rankin
- Marshall Linda L.
- Martin Merle P.
- Marvell Thomas B.
- Mathews M. Cash
- Mays G. Larry
- McDermott John T.
- McDermott John T.
- McDonald H. Graham
- McEwen Craig A.
- Meador Daniel J.
- Metrick Dennis L.
- Michels M. Janice
- Miller Neal
- Milner Neal
- Morgan Dennis E.
- Nase Jonathan P.
- Nejelski Paul
- Nejelski Paul
- Nelson Robert L.
- Neubauer David W.
- Plank Leonard E.
- Polansky Larry
- Puro Steven
- Quinn Robert E.
- Robinson James W.
- Rosen Lawrence
- Rosenberg Maurice
- Saari David J.
- Saari David J.
- Saari David J.
- Sanders Joseph
- Scott I. R.
- Shannon Charles P.
- Shannon Charles P.
- Silbert Jonathan
- Stauber Alvin
- Stentz Steven
- Stern Duke Nordlinger
- Stie John
- Stout Ronald M.
- Sundeen Richard A.
- Tait Jan
- Talarico Susette M.
- Tobin Robert W.
- Tucker Edwin W.
- Tucker Edwin W.
- Volenik Adrienne
- Walker Kenneth E.
- Wasby Stephen L.
- Weeks Kent M.
- Weinstein David
- Weller Steven
- Wheeler Russell R.
- Wheeler Russell R.
- Wice Paul B.
- Wice Paul B.
- Wick Karen A.
- Willison David
- Wolf Jo Beth
- Woodward James G.
- Zaffarano Mark A.
- Zemans Frances Kahn
- Zemans Frances Kahn
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
- Author
- Aaron James Holland
- Abdullah Jumana T.
- Abrams Jonathan M.
- Abrashoff Riley
- Acevedo Andres B.
- Acha Iker
- Acosta Daniela M. Meza
- Adam Megan M.
- Adams Dante Q.
- Adams Elena R
- Adams Kalvyn N
- Akbar Zainab A.
- Akruwala Ushmi H.
- Al-Ghazwi Adel
- AlAbbas Batool H.
- Alahmed Mohammed S.
- AlAwadhi Areej A.
- Albakr Mohammed A.
- Albalushi Yusef J.
- Albaum Jonathan
- Aldhamen Ahmed
- Ales Nolan
- Alesmail Mohammad
- Alhabeeb Abdulelah
- Alhamli Dania
- AlHarbi Yazeed A.
- Alhuseini Isehaq
- Alkaabi Suhail
- Alkhezzi Tameem
- Alkubaisi Mohamed
- Allanqawi Nasser
- Allsbrook Martin
- Almohsen Yousef A.
- Almquist Justin Thomas
- Alnaji Teeb
- Alnasrallah Yousef A
- Alonzi Nicholas
- Alosaimi Meshal
- Alqabani Emeen
- Alrubaie Mohammad
- Alsinan Reema A.
- Altenbern Ava L.
- Altokhais Abdullah
- Alyami Saleh A.
- Ameijenda Federico
- Amer Hamzi
- Amos Meggan
- Anderson Hunter J.
- Andrew Carter
- Andringa Jesse C
- Angwin Abigail
- Aradhya Arvind J.
- Aramians Andrew
- Arango Camila Villamil
- Archibald Jack. W.
- Arias-Robles Brian A.
- Aryan Maryam
- Ash Kevin
- Astalos Justin
- Atchley-Rivers N. S.
- Augenstein Dakota N.
- Austin Bryce W.
- Avula Abhinav
- Aycock Matthew C.
- Baflah Abdulrahman A.
- Balaji Sahana
- Balajonda Brian
- Balcer Leo M
- Baldwin James O.
- Banda David J
- Bard Titus
- Barmore Abby
- Barnes Grant M.
- Barnhart Logan D. W.
- Barone Kevin M.
- Bartman Jessica L.
- Bassel Claire
- Bastias Catalina S
- Bat-Ulzii Batchimeg
- Batra Jasleen
- Battist Lexi
- Bay Joshua
- Beach Simone
- Beard Sara
- Beato Quinn I
- Beattie Ryan
- Beatty Thomas
- Beauprez Jacob N.
- Beck Lily
- Beck M. G.
- Becker Simone E.
- Behr Braden
- Behrer Timothy A.
- Beijer Joshua
- Belei Brennan J.
- Belknap Annelene L.
- Bell Aislyn
- Bence Caden
- Benke Evan
- Berhanu Naomi
- Berriman-Rozen Zachary D.
- Bertuccio Chrisanna
- Berv Owen A.
- Biediger Blaine B.
- Biehle Samuel J
- Billig Brennen
- Billingsley Jacob
- Billman Jayce A.
- Biron Connor J.
- Bisacca Gabrielle E.
- Blake Cassidy A.
- Blandon Guillermo
- Blevins Olivia
- Blouin Ethan
- Bodzianowski Michal
- Boeyink Taylor A.
- Bondar Matthew
- Bone Lauren
- Bonilla Alberto Espinosa de los Monteros
- Borelli William T
- Borgerding Luke R.
- Bowen Troy
- Boyer Aidan
- Boyer Christine
- Boyle Aidan P.
- Boyne Tom
- Branch Donovan
- Brecl Ariana E.
- Brennan David J.
- Brimhall Alexander J
- Brockman Jennifer L.
- Brookins Sarah
- Brown Cameron L.
- Brown Gabriel T.
- Brown Ryan
- Brownlow Jordi
- Brumage-Heller Grant
- Brumley Preston J.
- Bryan Samuel
- Brzostowicz A.
- Buhamad Maryam
- Bullard-Connor Gigi
- Bunsow J. R. Ramirez
- Burns Annemarie C.
- Burritt John J.
- Burton Nicholas David
- Burton Taylor
- Busch Celeste
- Butler Dylan R.
- Buxton B. W.
- Cabbage Carter C.
- Cage Breonna
- Cahn Jackson R.
- Cai Yijian
- Campbell Andrew J
- Canales Braden P.
- Cancio Alejandro R.
- Carey Luke
- Carillion Emma L.
- Carpender Michael Andrew
- Carpenter Emily
- Chadda Shivank
- Chambers Paige
- Chanders Jasey
- Chandler Olivia M.
- Chang Ethan C.
- Chaparro David
- Chapman Logan T.
- Chapman Mitchell G.
- Chavali S.
- Chavez Luis
- Cheang Nathan M.
- Chen Judy
- Chen Kevin
- Chen Lily
- Chen Sam
- Chhetri Jenisha
- Chiles Bradyn
- Chizmar Kayla M.
- Christiansen Katherine E
- Cisne Nicholas A.
- Cisneros Alexis
- Clark David B.
- Clarke Evelyn
- Clarkson Peter C
- Clausi Alexis R.
- Cochran Brooke
- Coe Ryan W.
- Coleman-Plante Aislinn
- Colleran Jake R.
- Colleran Zachary
- Collier Curran
- Collins Jack C.
- Collins Nathaniel A.
- Collins Sarah
- Colozzi Michael
- Colter Aurora
- Cone Rebecca A.
- Conroy Thomas C.
- Conti Reese
- Contizano Charles J.
- Cool Destiny J.
- Cooper Nicholas M.
- Corbitt Jessica S
- Courtney Jonas
- Courtney Olivia
- Cox Corben L.
- Craig Wilmsen B.
- Creany Joshua B.
- Crews Anastasia
- Crocker K. A.
- Croteau A. J.
- Crow Christian J.
- Cruse Zoe
- Cruz Avril
- Curnow Tyler L.
- Current Hayden
- Curry Riley T.
- Cutler Libby
- Cyr Aidan St.
- Dabberdt Frederick M.
- Daboub Johnston
- Damgaard Olivia
- Das Swagatam
- Davis Emma A. B.
- de La Beaujardiere Tristan
- DeBarros Elyse
- Deel Sean
- Del Foco Leonardo
- Delasantos Megan E.
- Deng Tianyue
- Derwin Zachary
- Desai Om
- Dewey Kai
- Dias John S.
- Dice Kenzie A.
- Dick R.
- Dicken Cyrus A.
- Dietrick Henry
- Dinser Alexis M.
- Dixon Alyssa M.
- Dixon Thomas J.
- Do Helen C.
- Doan Chris H
- Doane Connor
- Dodrill Joshua
- Doermer Timothy
- Dominguez J.
- Dominguez Lizbeth Montoya
- Domke Emerson N.
- Doran Caroline R.
- Dorr Jackson A.
- Dorricott Philip
- Dresdner Danielle C.
- Driscoll Kailer H.
- Driscoll Michael
- Duncan Sheridan J.
- Dunlap Christian
- Dunn Gabrielle M.
- Duong Tien Q.
- Dupeyron Tomi Oshima
- Dvorak Peter
- East Andrew
- East Andrew N.
- Edwards Bree
- Ehrlich Lauren
- Elbashir Sara I.
- Engelhardt Rasce
- Engelstad Jacob
- England Colin
- Enrich Andrew
- Erickson Abbey
- Erickson Benjamin
- Erikson James W.
- Evans Nathan
- Ewing Calvin A
- Eyeson Elizabeth A.
- Faber Ian
- Fails Avery M.
- Fauntleroy John T
- Fell Kevin
- Feng Zitian
- Fenwick Logan D.
- Feoktistov Nikita
- Fife Ryann
- Figueirinhas John Alfred D.
- Fisch Jean-Paul
- Fischer Emmalee
- Fischer-White Jules
- Fitton Aidan F.
- Fix Alexander
- Flackett Lydia
- Flores Fernando
- Floyd Aidan
- Folarin Adeduni
- Forbes Aidan E.
- Fortino Elise
- Fougere Benjamin L.
- Fowler Alexandra A.
- Fox Margaret
- French James M.
- French Katherine V.
- Frick Florian G.
- Fuchs Calvin R.
- Fuhrman Bethany E. S.
- Furney Sebastian
- Gabir Moutamen
- Galarraga Gabriela
- Gale Skylar
- Ganesan Koushik
- Gapin Keala C.
- Garscadden A. J.
- Gasser Rachel
- Gayou Lily
- Gearhart Emily E.
- Geerdts T. R.
- Geisman Jane
- Geneser Julianne R.
- Genne SL
- Gentile Julia G
- Gentry Eleanor
- George Jacob D.
- Georgiades Nathaniel James
- Gerhardstein Phillip
- Gersabeck Clint
- Ghaith Bandar Abu
- Ghiassi Dorsa
- Giebner B. C.
- Gilmartin Dalton
- Gilpatrick Connor B.
- Gjini Michael
- Golden Olivia
- Golding Nathan T.
- Goldsberry C. A.
- Gomez Angel A.
- Gomez Angel R.
- Gopalakrishnan Sean
- Gopalani Mariam
- Gotlib Nicholas
- Graham Alaina S.
- Gray Michael J
- Gregory Alannah H.
- Gregory Joshua A.
- Grell Kristyn
- Griego Justus
- Griffin Kyle J.
- Griffin Nicholas F.
- Guerrero Matt
- Gunderson Nicole
- Guo Mutian
- Gustavsson E. R.
- Hach Grace K.
- Haile L. N.
- Haines Jessica
- Hale Jack J. Mc
- Hales Ryder Buchanan
- Haley Mark S.
- Hall Jacqueline L.
- Hamilton Sean R.
- Han Soonhee
- Hand Tyler
- Hanley Luke C.
- Hansen Connor M
- Hansen Joshua A.
- Hansson Jonathan
- Hao Tony Yunfei
- Haratsaris Nicholas
- Hardie Isabelle
- Hardwick Dillon F.
- Hares Cameron T.
- Harris Coyle M.
- Harris Logan Swous
- Hart Omer
- Hashiro Kyle
- Hattendorf Elsie
- Haubrich Calder
- Hawat Elijah
- Hayrynen Griffin A.
- Heintz Danielle A.
- Hellweg Tim
- Hernandez Angel
- Herrera Emanuel
- Herrington Robert N.
- Herwig Tim
- Hesse Troy M.
- Hiatt Quinn
- Hibbard Lea Pearl
- Hicks Andrew J.
- Hicks Imari R.
- Highhouse Nigel
- Hildebrand Annalise K.
- Hill Hallie
- Hill Paula
- Hintsa Evan
- Hirschmann Anna E.
- Hitt Travis
- Ho Ella
- Hoang Thi D
- Hoff Isabelle J.
- Hoffman Alex
- Hogen Blake A.
- Horne Linda
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- Wallace Steven P.
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- Wang Hongda
- Wang Jiawei
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- Watson James Adam
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- Weigand Anthony A
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- Wickenden Evan
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- Wolle Jackson R.
- Wood Travis M.
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- Woodraska Donald L.
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- Wu Mengyu
- Xiao Catherine
- Yang Jianing
- Yang Zhanchao
- Yegovtsev Nikolay
- Young Isabel
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- Zenner Thomas
- Zhang Jiaqi
- zhang Jinhua
- Zhao Noah Y.
- Zhao Tiannie
- Zhao Tianwei
- Zhou Chongrui
- Ziebold Josh J
- Ziegler Lucas J.
- Zimmermann Ingrid H
- Zygmunt James C.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 09/05/2023
- Field of study
Flare frequency distributions represent a key approach to addressing one of
the largest problems in solar and stellar physics: determining the mechanism
that counter-intuitively heats coronae to temperatures that are orders of
magnitude hotter than the corresponding photospheres. It is widely accepted
that the magnetic field is responsible for the heating, but there are two
competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To
date, neither can be directly observed. Nanoflares are, by definition,
extremely small, but their aggregate energy release could represent a
substantial heating mechanism, presuming they are sufficiently abundant. One
way to test this presumption is via the flare frequency distribution, which
describes how often flares of various energies occur. If the slope of the power
law fitting the flare frequency distribution is above a critical threshold,
α=2 as established in prior literature, then there should be a
sufficient abundance of nanoflares to explain coronal heating. We performed
>600 case studies of solar flares, made possible by an unprecedented number
of data analysts via three semesters of an undergraduate physics laboratory
course. This allowed us to include two crucial, but nontrivial, analysis
methods: pre-flare baseline subtraction and computation of the flare energy,
which requires determining flare start and stop times. We aggregated the
results of these analyses into a statistical study to determine that α=1.63±0.03. This is below the critical threshold, suggesting that Alfv\'en
waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The
Astrophysical Journal on 2023-05-09, volume 948, page 7
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
- Author
- Abassi Yama
- Abelin Jennifer G.
- Abolhalaj Milad
- Abraham Tara S.
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F.
- Adamus Tomasz
- Addepalli Murali
- Adjei Alex A.
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G.
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T.
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C.
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T.
- Alley Evan W.
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H. I.
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S.
- Antonia Scott J.
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F.
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M.
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B.
- Atkinson Victoria
- Au Katrina
- Autio Karen A.
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A.
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Barton Sunjay M.
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- Bauman Julie
- Baumgaertner Petra
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- Bornschlegl Svetlana
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- Bramante Simona
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- Brech Dorothee
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- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
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- Curti Brendan
- Da Costa Andre
- Dai Fu
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- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A.
- Daud Adil
- David Justin M.
- Davies Bronwyn
- de Boisferon Marc Hillairet
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H.
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
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- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dutcher Janice P.
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- D’Apuzzo Massimo
- Ebner Peggy
- Edwards Robert
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- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
- Eles Klara
- Ellies Lesley
- Elnaggar Omar
- Elvecrog James
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- Emerling Daniel
- Eng Charis
- Engelhard Victor H.
- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Fa’ak Faisal
- Femel Julia
- Feng JunLi
- Feng Yan
- Feng Zipei
- Feola Sara
- Fernandez Christian
- Fernando Ingrid
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- Fesenkova Valentyna
- Field Jessica J.
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- Fogler William
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- Foster Cathie
- Foster Rosemary
- Fotin-Mleczek Mariola
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- Francica Brian
- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Frey Alan
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- Friedman Alan
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- Fromm George
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- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
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- Walters R.K.
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- Wang Xueyang
- Wanying Zhu
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- Wei Shuying
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- White Deborah
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- Wicks S.J.
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- Willson J.
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- Wilson D.J.
- Wilson James F.
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- Winnard Sarah
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- Wong Joanna
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- Wood Hannah-Louise
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- Woodyatt Wiesia
- Woolley A.E.
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- Wright J.
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- Wrobel Nicola
- Wu Yang
- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier Kugan
- Xue X.
- Yadav A.
- Yang Jian
- Yassen Amr M.
- Yates Brian
- Ye C.
- Yun Nikki
- Zainy Tala
- Zak Anne
- Zaki Ahmed
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg Hugo
- Zechner Marie
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng Chenqing
- Zhou W.
- Zitter L.
- Zlatopolsky Menachem
- Zongo Olivier
- Zucchi P.
- Zyndorf Marissa
- Zöllner S.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease