5 research outputs found
Liposomi rivastigmina za isporuku u mozak intranazalnim putem
The present study is mainly aimed at delivering a drug into the brain via the intranasal route using a liposomal formulation. For this purpose, rivastigmine, which is used in the management of Alzheimer’s disease, was selectd as a model drug. Conventional liposomes were formulated by lipid layer hydration method using cholesterol and soya lecithin as lipid components. The concentration of rivastigmine in brain and plasma was studied in rat models after intranasal and oral administration of liposomes and free drug. A significantly higher level of drug was found in the brain with intranasal liposomes of rivastigmine compared to the intranasal free drug and the oral route. Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug. Delivering rivastigmine liposomes through the intranasal route for the treatment of Alzheimer’s disease might be a new approach to the management of this condition.Glavni cilj rada je razvoj liposoma za intranazalnu primjenu za isporuku lijeka u mozak. U tu svrhu izabran je rivastigmin kao modelni lijek koji se upotrebljava u terapiji Alzheimerove bolesti. Liposomi su pripravljeni metodom hidratacije lipidnog sloja koristeći kolesterol i lecitin iz soje kao lipidne komponente. Praćena je koncentracija rivastigmina u mozgu i plazmi nakon intranazalne i peroralne primjene liposoma i slobodnog lijeka. S intranazalnim liposomima rivastigmina postignuta je značajno veća koncentracija lijeka u mozgu. Osim toga intranazalni liposomi imaju dulje vrijeme poluživota u mozgu. Intranazalna primjena liposoma rivastigmina mogla bi predstavljati novi pristup terapiji Alzheimerove bolesti
Selective Modulation of Internal Charge Transfer and Photoinduced Electron Transfer Processes in <i>N</i>‑Aryl-1,8-Naphthalimide Derivatives: Applications in Reaction-Based Fluorogenic Sensing of Sulfide
Three
reaction-based fluorescent probes based on two new naphthalimide
platforms were developed for the detection of H<sub>2</sub>S. A new
approach in detecting H<sub>2</sub>S by the reduction of an azide
to a triazene intermediate in aqueous media is reported. Given their
design features, these chemodosimeters provide useful insights into
the relatively unexplored area of C<sub>0</sub> spacers between receptor:reporter
components. The <i>N</i>-aryl-1,8-naphthalimide platform
features straightforward placement of the internal charge transfer
and photoinduced electron transfer (PET) modulators on the same molecule.
In the three examples presented, the <i>N</i>-aryl component
proved to be an effective photophysical device as it allows the placement
of a PET modulator at the strategically important and less explored
imide position of 1,8-naphthalimides. These probes or dosimetric agents
demonstrated good selectivity, two-signal response, and the desirable
OFF–ON fluorescence response. By implementation of both the
azido and nitro group as sulfide-reactive functionalities on the same
chemosensory platform in probe SNAN-3, a much broader range of H<sub>2</sub>S can be detected. Remarkably, probe SNAN-3 exhibits both
a dual-emission and dual-response for the detection of sulfide in
aqueous solution