777 research outputs found

    Nanosat Technology And Managed Risk; An Update Of The CYGNSS Microsatellite Constellation Mission Development

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    Existing and forecasted budget constraints continue to drive innovative solutions for space-based mission applications. NASA’s Earth science mission, the Cyclone Global Navigation Satellite System (CYGNSS) was selected as part of NASA\u27s Earth Venture program with a total mission cost cap (excluding launch vehicle) of $103M. Performing valuable science at low cost is only possible given technology innovation and a development risk posture higher than typically accepted for NASA missions. CYGNSS is being designed to address present tropical cyclone intensity forecasting deficiencies. These deficiencies are thought to be the root cause for essentially no improvement in the accuracy of the storm’s intensity prediction (Classification and Category levels) since 1990 while tropical storm track forecasts have improved in accuracy by ~50%. The mission will combine the all-weather performance of GNSS bi-static ocean surface scatterometry with the sampling properties of a satellite constellation to provide science measurements never before available to the tropical cyclone operational and research communities. The mission cost cap dictates that the CYGNSS flight segment of 8 Observatories, each carrying a 4-channel GPS-based scatterometer, all be launched on a single launch vehicle. The mission will demonstrate how recent developments in nano- and micro-satellite technology integration, including recent developments in star trackers and reaction wheels, when combined with a managed risk approach, can be applied as cost effective solutions to fill capability voids of large-scale observatories. CYGNSS will also demonstrate low cost science mission operations, how to safely deploy a constellation from a single launch vehicle without collision, and a low-cost method for constellation configuration management. The CYGNSS SmallSat 2014 paper will provide an update of the mission system development status, an overview of how a synergistic approach between flight and ground segments enables a cost effective science mission solution, and a description of our approach to constellation configuration control

    Prospectus, March 7, 1969

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    SPOON RIVER TRIUMPHS; 3 Teachers Exhibit; PC Board Meets, Students Get Voice; PSA; Editors\u27 Column; Readerspeak; Supersnake; Wild In The Streets; Finally Found; Volger Stresses Self-Improvement; Counselors\u27 Corner…; Scholarships For Librarians Offered; Creative Writer\u27s Workshop; Tea Party; Re: life after death; Sterile Like Ink; For Lainie; on self immolation in washington d.c.; a roomful of women; Open House; SG Passes Rights & Freedoms; Allerton Committee Asks For PC Action; Inner Organization Council Formed; Agriculture Club Formed At PC; Start Ski Club For PC Students; Junior Colleges Crowded; Nurses Form New Organization; Hilltoppers Lose Regional Game; Ask Minerva; Heartbreaker For PC Cobras; Cobras Score High In Performance; Druts Remain Undefeated; Award Of The Year; IM All-Star Team To Playhttps://spark.parkland.edu/prospectus_1969/1010/thumbnail.jp

    Response of Herbicide-Resistant Palmer Amaranth ( Amaranthus palmeri

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    Palmer amaranth is a very problematic weed in several crops in the southern USA due to its competitive ability and resistance to herbicides representing different mechanisms of action. Variation in growth and subsequent interference of North Carolina Palmer amaranth accessions has not been examined. A greenhouse experiment determined response of 15 North Carolina Palmer amaranth accessions to drought stress beginning 15 days after seedling emergence (DAE) for a duration of 3, 5, 7, and 9 days. Following exposure to drought, plants were grown under optimal moisture conditions until harvest at 30 DAE. Five accessions each of glyphosate-resistant (GR), acetolactate synthase inhibitor-resistant (ALSR), and acetolactate synthase inhibitor-susceptible and glyphosate-susceptible (ALSS/GS) were compared. Variation in response to drought stress, based on height and dry weight reduction relative to nonstressed controls, was noted among accessions. Stress for 3 or more days affected height and dry weight. Height and dry weight of GR and ALSR accession groups were reduced less by drought than the ALSS/GS accession group. Results suggest a possible relationship between herbicide resistance and ability of Palmer amaranth to withstand drought stress and thus a possible competitive advantage for resistant accessions under limited moisture availability

    DNA Damage Mediated S and G2 Checkpoints in Human Embryonal Carcinoma Cells

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    For mouse embryonic stem (ES) cells, the importance of the S and G2 cell cycle checkpoints for genomic integrity is increased by the absence of the G1 checkpoint. We have investigated ionizing radiation (IR)-mediated cell cycle checkpoints in undifferentiated and retinoic acid-differentiated human embryonal carcinoma (EC) cells. Like mouse ES cells, human EC cells did not undergo G1 arrest after IR but displayed a prominent S-phase delay followed by a G2-phase delay. In contrast, although differentiated EC cells also failed to arrest at G1-phase after IR, they quickly exited S-phase and arrested in G2-phase. In differentiated EC cells, the G2-M-phase cyclin B1/CDC2 complex was upregulated after IR, but the G1-S-phase cyclin E and the cyclin E/CDK2 complex were expressed at constitutively low levels, which could be an important factor distinguishing DNA damage responses between undifferentiated and differentiated EC cells. S-phase arrest and expression of p21 could be inhibited by 7-hydroxystaurosporine, suggesting that the ataxia-telangiectasia and Rad-3-related-checkpoint kinase 1 (ATR-CHK1), and p21 pathways might play a role in the IR-mediated S-phase checkpoint in EC cells. IR-mediated phosphorylation of ataxia-telangiectasia mutated, (CHK1), and checkpoint kinase 2 were distinctly higher in undifferentiated EC cells compared with differentiated EC cells. Combined with the prominent S and G2 checkpoints and a more efficient DNA damage repair system, these mechanisms operate together in the maintenance of genome stability for EC cells. Stem Cells 2009;27:568–57

    The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

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    The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

    Test-retest and between-site reliability in a multicenter fMRI study

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    In the present report, estimates of test–retest and between-site reliability of fMRI assessments were produced in the context of a multicenter fMRI reliability study (FBIRN Phase 1, www.nbirn.net). Five subjects were scanned on 10 MRI scanners on two occasions. The fMRI task was a simple block design sensorimotor task. The impulse response functions to the stimulation block were derived using an FIR-deconvolution analysis with FMRISTAT. Six functionally-derived ROIs covering the visual, auditory and motor cortices, created from a prior analysis, were used. Two dependent variables were compared: percent signal change and contrast-to-noise-ratio. Reliability was assessed with intraclass correlation coefficients derived from a variance components analysis. Test–retest reliability was high, but initially, between-site reliability was low, indicating a strong contribution from site and site-by-subject variance. However, a number of factors that can markedly improve between-site reliability were uncovered, including increasing the size of the ROIs, adjusting for smoothness differences, and inclusion of additional runs. By employing multiple steps, between-site reliability for 3T scanners was increased by 123%. Dropping one site at a time and assessing reliability can be a useful method of assessing the sensitivity of the results to particular sites. These findings should provide guidance to others on the best practices for future multicenter studies

    The James Webb Space Telescope Mission: Optical Telescope Element Design, Development, and Performance

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    The James Webb Space Telescope (JWST) is a large, infrared space telescope that has recently started its science program which will enable breakthroughs in astrophysics and planetary science. Notably, JWST will provide the very first observations of the earliest luminous objects in the Universe and start a new era of exoplanet atmospheric characterization. This transformative science is enabled by a 6.6 m telescope that is passively cooled with a 5-layer sunshield. The primary mirror is comprised of 18 controllable, low areal density hexagonal segments, that were aligned and phased relative to each other in orbit using innovative image-based wavefront sensing and control algorithms. This revolutionary telescope took more than two decades to develop with a widely distributed team across engineering disciplines. We present an overview of the telescope requirements, architecture, development, superb on-orbit performance, and lessons learned. JWST successfully demonstrates a segmented aperture space telescope and establishes a path to building even larger space telescopes.Comment: accepted by PASP for JWST Overview Special Issue; 34 pages, 25 figure
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