544 research outputs found

    Damage identification based on response-only measurements using cepstrum analysis and artificial neural networks

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    This article presents a response-only structural health monitoring technique that utilises cepstrum analysis and artificial neural networks for the identification of damage in civil engineering structures. The method begins by applying cepstrum-based operational modal analysis, which separates source and transmission path effects to determine the structure's frequency response functions from response measurements only. Principal component analysis is applied to the obtained frequency response functions to reduce the data size, and structural damage is then detected using a two-stage ensemble of artificial neural networks. The proposed method is verified both experimentally and numerically using a laboratory two-storey framed structure and a finite element representation, both subjected to a single excitation. The laboratory structure is tested on a large-scale shake table generating ambient loading of Gaussian distribution. In the numerical investigation, the same input is applied to the finite model, but the obtained responses are polluted with different levels of white Gaussian noise to better replicate real-life conditions. The damage is simulated in the experimental and numerical investigations by changing the condition of individual joint elements from fixed to pinned. In total, four single joint changes are investigated. The results of the investigation show that the proposed method is effective in identifying joint damage in a multi-storey structure based on response-only measurements in the presence of a single input. Because the technique does not require a precise knowledge of the excitation, it has the potential for use in online structural health monitoring. Recommendations are given as to how the method could be applied to the more general multiple-input case. © The Author(s) 2014

    Properties of the Broad-Range Nematic Phase of a Laterally Linked H-Shaped Liquid Crystal Dimer

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    In search for novel nematic materials, a laterally linked H-shaped liquid crystal dimer have been synthesized and characterized. The distinct feature of the material is a very broad temperature range (about 50 oC) of the nematic phase, which is in contrast with other reported H-dimers that show predominantly smectic phases. The material exhibits interesting textural features at the scale of nanometers (presence of smectic clusters) and at the macroscopic scales. Namely, at a certain temperature, the flat samples of the material show occurrence of domain walls. These domain walls are caused by the surface anchoring transition and separate regions with differently tilted director. Both above and below this transition temperature the material represents a uniaxial nematic, as confirmed by the studies of defects in flat samples and samples with colloidal inclusions, freely suspended drops, X-ray diffraction and transmission electron microscopy.Comment: 30 pages (including Supplementary Information), 7 Figure

    In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts

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    Background: Acute lymphoblastic leukemia (ALL) remains one of the most common causes of cancer-related mortality in children. Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases, and aberrations in the PI3K pathway are associated with several hematological malignancies, including ALL. Duvelisib (Copiktra) is an orally available, small molecule dual inhibitor of PI3Kδ and PI3Kγ, that is Food and Drug Administration (FDA) approved for the treatment of relapsed/refractory chronic lymphocytic leukemia and small lymphocytic lymphoma. Here, we report the efficacy of duvelisib against a panel of pediatric ALL patient-derived xenografts (PDXs). Procedures: Thirty PDXs were selected for a single mouse trial based on PI3Kδ (PIK3CD) and PI3Kγ (PIK3CG) expression and mutational status. PDXs were grown orthotopically in NSG (NOD.Cg-PrkdcscidIL2rgtm1Wjl/SzJAusb) mice, and engraftment was evaluated by enumerating the proportion of human versus mouse CD45+ cells (%huCD45+) in the peripheral blood. Treatment commenced when the %huCD45+ reached greater than or equal to 1%, and events were predefined as %huCD45+ greater than or equal to 25% or leukemia-related morbidity. Duvelisib was administered per oral (50 mg/kg, twice daily for 28 days). Drug efficacy was assessed by event-free survival and stringent objective response measures. Results: PI3Kδ and PI3Kγ mRNA expression was significantly higher in B-lineage than T-lineage ALL PDXs (p-values <.0001). Duvelisib was well-tolerated and reduced leukemia cells in the peripheral blood in four PDXs, but with only one objective response. There was no obvious relationship between duvelisib efficacy and PI3Kδ or PI3Kγ expression or mutation status, nor was the in vivo response to duvelisib subtype dependent. Conclusions: Duvelisib demonstrated limited in vivo activity against ALL PDXs

    Effective AdS/renormalized CFT

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    For an effective AdS theory, we present a simple prescription to compute the renormalization of its dual boundary field theory. In particular, we define anomalous dimension holographically as the dependence of the wave-function renormalization factor on the radial cutoff in the Poincare patch of AdS. With this definition, the anomalous dimensions of both single- and double- trace operators are calculated. Three different dualities are considered with the field theory being CFT, CFT with a double-trace deformation and spontaneously broken CFT. For the second dual pair, we compute scaling corrections at the UV and IR fixed points of the RG flow triggered by the double-trace deformation. For the last case, we discuss whether our prescription is sensitive to the AdS interior or equivalently, the IR physics of the dual field theory.Comment: 20 pages, 3 figure

    Planetary bearing defect detection in a commercial helicopter main gearbox with vibration and acoustic emission

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    The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Helicopter gearboxes significantly differ from other transmission types and exhibit unique behaviors that reduce the effectiveness of traditional fault diagnostics methods. In addition, due to lack of redundancy, helicopter transmission failure can lead to catastrophic accidents. Bearing faults in helicopter gearboxes are difficult to discriminate due to the low signal to noise ratio (SNR) in the presence of gear vibration. In addition, the vibration response from the planet gear bearings must be transmitted via a time-varying path through the ring gear to externally mounted accelerometers, which cause yet further bearing vibration signal suppression. This research programme has resulted in the successful proof of concept of a broadband wireless transmission sensor that incorporates power scavenging whilst operating within a helicopter gearbox. In addition, this paper investigates the application of signal separation techniques in detection of bearing faults within the epicyclic module of a large helicopter (CS-29) main gearbox using vibration and Acoustic Emissions (AE). It compares their effectiveness for various operating conditions. Three signal processing techniques including an adaptive filter, spectral kurtosis and envelope analysis, were combined for this investigation. In addition, this research discusses the feasibility of using AE for helicopter gearbox monitoring

    The Pioneer Anomaly

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    Radio-metric Doppler tracking data received from the Pioneer 10 and 11 spacecraft from heliocentric distances of 20-70 AU has consistently indicated the presence of a small, anomalous, blue-shifted frequency drift uniformly changing with a rate of ~6 x 10^{-9} Hz/s. Ultimately, the drift was interpreted as a constant sunward deceleration of each particular spacecraft at the level of a_P = (8.74 +/- 1.33) x 10^{-10} m/s^2. This apparent violation of the Newton's gravitational inverse-square law has become known as the Pioneer anomaly; the nature of this anomaly remains unexplained. In this review, we summarize the current knowledge of the physical properties of the anomaly and the conditions that led to its detection and characterization. We review various mechanisms proposed to explain the anomaly and discuss the current state of efforts to determine its nature. A comprehensive new investigation of the anomalous behavior of the two Pioneers has begun recently. The new efforts rely on the much-extended set of radio-metric Doppler data for both spacecraft in conjunction with the newly available complete record of their telemetry files and a large archive of original project documentation. As the new study is yet to report its findings, this review provides the necessary background for the new results to appear in the near future. In particular, we provide a significant amount of information on the design, operations and behavior of the two Pioneers during their entire missions, including descriptions of various data formats and techniques used for their navigation and radio-science data analysis. As most of this information was recovered relatively recently, it was not used in the previous studies of the Pioneer anomaly, but it is critical for the new investigation.Comment: 165 pages, 40 figures, 16 tables; accepted for publication in Living Reviews in Relativit

    Accumulation of Biomass and Mineral Elements with Calendar Time by Corn: Application of the Expanded Growth Model

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    The expanded growth model is developed to describe accumulation of plant biomass (Mg ha−1) and mineral elements (kg ha−1) in with calendar time (wk). Accumulation of plant biomass with calendar time occurs as a result of photosynthesis for green land-based plants. A corresponding accumulation of mineral elements such as nitrogen, phosphorus, and potassium occurs from the soil through plant roots. In this analysis, the expanded growth model is tested against high quality, published data on corn (Zea mays L.) growth. Data from a field study in South Carolina was used to evaluate the application of the model, where the planting time of April 2 in the field study maximized the capture of solar energy for biomass production. The growth model predicts a simple linear relationship between biomass yield and the growth quantifier, which is confirmed with the data. The growth quantifier incorporates the unit processes of distribution of solar energy which drives biomass accumulation by photosynthesis, partitioning of biomass between light-gathering and structural components of the plants, and an aging function. A hyperbolic relationship between plant nutrient uptake and biomass yield is assumed, and is confirmed for the mineral elements nitrogen (N), phosphorus (P), and potassium (K). It is concluded that the rate limiting process in the system is biomass accumulation by photosynthesis and that nutrient accumulation occurs in virtual equilibrium with biomass accumulation

    New AdS solitons and brane worlds with compact extra-dimensions

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    We construct new static, asymptotically AdS solutions where the conformal infinity is the product of Minkowski spacetime MnM_n and a sphere SmS^m. Both globally regular, soliton-type solutions and black hole solutions are considered. The black holes can be viewed as natural AdS generalizations of the Schwarzschild black branes in Kaluza-Klein theory. The solitons provide new brane-world models with compact extra-dimensions. Different from the Randall-Sundrum single-brane scenario, a Schwarzschild black hole on the Ricci flat part of these branes does not lead to a naked singularity in the bulk.Comment: 28 pages, 4 figure

    Rolling element bearing fault diagnosis using laplace-wavelet envelope power spectrum

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    The bearing characteristic frequencies (BCF) contain very little energy, and are usually overwhelmed by noise and higher levels of macro-structural vibrations. They are difficult to find in their frequency spectra when using the common technique of fast fourier transforms (FFT). Therefore, Envelope Detection (ED) has always been used with FFT to identify faults occurring at the BCF. However, the computation of the ED is suffering to strictly define the resonance frequency band. In this paper, an alternative approach based on the Laplace-wavelet enveloped power spectrum is proposed. The Laplace-Wavelet shape parameters are optimized based on Kurtosis maximization criteria. The results for simulated as well as real bearing vibration signal show the effectiveness of the proposed method to extract the bearing fault characteristic frequencies from the resonant frequency band.Khalid F. Al-Raheem, Asok Roy, K. P. Ramachandran, D. K. Harrison, and Steven Grainge
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