A perceived gap between invasive species research and stakeholder priorities

Information from research has an important role to play in shaping policy and management responses to biological invasions but concern has been raised that research focuses more on furthering knowledge than on delivering practical solutions. We collated 449 priority areas for science and management from 160 stakeholders including practitioners, researchers and policy makers or advisors working with invasive species, and then compared them to the topics of 789 papers published in eight journals over the same time period (2009–2010). Whilst research papers addressed most of the priority areas identified by stakeholders, there was a difference in geographic and biological scales between the two, with individual studies addressing multiple priority areas but focusing on specific species and locations. We hypothesise that this difference in focal scales, combined with a lack of literature relating directly to management, contributes to the perception that invasive species research is not sufficiently geared towards delivering practical solutions. By emphasising the practical applications of applied research, and ensuring that pure research is translated or synthesised so that the implications are better understood, both the management of invasive species and the theoretical science of invasion biology can be enhanced

"Community Development Banking, A Proposal to Establish a Nationwide System of Community Development Banks"

This brief proposes that the establishment of a nationwide system of community development banks (CDBs) would advance the capital development of the economy. The proposal is based on the notion that a critical function of the financial system is not being adequately performed by existing institutions for low-income citizens, inner-city minorities, and entrepreneurs who seek modest financing for small businesses. The primary goals of the CDBs are to deliver credit, payment, and savings opportunities to communities not well served by banks and to provide financing throughout a designated area for businesses too small to attract the interest of the investment banking and normal commercial banking communities.

Scalar field localization on a brane with cosmological constant

We address the localization of a scalar field, whose bulk-mass M is considered in a wide range including the tachyonic region,on a three-brane. The brane with non-zero cosmological constant $\lambda$ is embedded in five dimensional bulk space. We find in this case that the trapped scalar could have mass $m$ which has an upper bound and expressed as $m^2=m_0^2+\alpha M^2\leq \beta |\lambda|$ with the calculable numbers $m_0^2, \alpha, \beta$. We point out that this result would be important to study the stability of the brane and cosmological problems based on the brane-world.Comment: 14 pages, 5 figure

Constraints on AdS5AdS_5 Embeddings

We show that the embedding of either a static or a time dependent maximally 3-symmetric brane with non-zero spatial curvature $k$ into a non-compactified $AdS_5$ bulk does not yield exponential suppression of the geometry away from the brane. Implications of this result for brane-localized gravity are discussed.Comment: RevTeX, 9 pages (updated version v2, conclusions unchanged after extension to the non-static case

Bulk Scalar Stabilization of the Radion without Metric Back-Reaction in the Randall-Sundrum Model

Generalizations of the Randall-Sundrum model containing a bulk scalar field $\Phi$ interacting with the curvature $R$ through the general coupling $R f(\Phi)$ are considered. We derive the general form of the effective 4D potential for the spin-zero fields and show that in the mass matrix the radion mixes with the Kaluza-Klein modes of the bulk scalar fluctuations. We demonstrate that it is possible to choose a non-trivial background form $\Phi_0(y)$ (where $y$ is the extra dimension coordinate) for the bulk scalar field such that the exact Randall-Sundrum metric is preserved (i.e. such that there is no back-reaction). We compute the mass matrix for the radion and the KK modes of the excitations of the bulk scalar relative to the background configuration $\Phi_0(y)$ and find that the resulting mass matrix implies a non-zero value for the mass of the radion (identified as the state with the lowest eigenvalue of the scalar mass matrix). We find that this mass is suppressed relative to the Planck scale by the standard warp factor needed to explain the hierarchy puzzle, implying that a mass \sim 1\tev is a natural order of magnitude for the radion mass. The general considerations are illustrated in the case of a model containing an $R\Phi^2$ interaction term.Comment: 22 pages, 3 figure

The inter-rater reliability of the diagnosis of surgical site infection in the context of a clinical trial.

ObjectivesThe diagnosis of surgical site infection following endoprosthetic reconstruction for bone tumours is frequently a subjective diagnosis. Large clinical trials use blinded Central Adjudication Committees (CACs) to minimise the variability and bias associated with assessing a clinical outcome. The aim of this study was to determine the level of inter-rater and intra-rater agreement in the diagnosis of surgical site infection in the context of a clinical trial.Materials and methodsThe Prophylactic Antibiotic Regimens in Tumour Surgery (PARITY) trial CAC adjudicated 29 non-PARITY cases of lower extremity endoprosthetic reconstruction. The CAC members classified each case according to the Centers for Disease Control (CDC) criteria for surgical site infection (superficial, deep, or organ space). Combinatorial analysis was used to calculate the smallest CAC panel size required to maximise agreement. A final meeting was held to establish a consensus.ResultsFull or near consensus was reached in 20 of the 29 cases. The Fleiss kappa value was calculated as 0.44 (95% confidence interval (CI) 0.35 to 0.53), or moderate agreement. The greatest statistical agreement was observed in the outcome of no infection, 0.61 (95% CI 0.49 to 0.72, substantial agreement). Panelists reached a full consensus in 12 of 29 cases and near consensus in five of 29 cases when CDC criteria were used (superficial, deep or organ space). A stable maximum Fleiss kappa of 0.46 (95% CI 0.50 to 0.35) at CAC sizes greater than three members was obtained.ConclusionsThere is substantial agreement among the members of the PARITY CAC regarding the presence or absence of surgical site infection. Agreement on the level of infection, however, is more challenging. Additional clinical information routinely collected by the prospective PARITY trial may improve the discriminatory capacity of the CAC in the parent study for the diagnosis of infection.Cite this article: J. Nuttall, N. Evaniew, P. Thornley, A. Griffin, B. Deheshi, T. O'Shea, J. Wunder, P. Ferguson, R. L. Randall, R. Turcotte, P. Schneider, P. McKay, M. Bhandari, M. Ghert. The inter-rater reliability of the diagnosis of surgical site infection in the context of a clinical trial. Bone Joint Res 2016;5:347-352. DOI: 10.1302/2046-3758.58.BJR-2016-0036.R1

On a Covariant Determination of Mass Scales in Warped Backgrounds

We propose a method of determining masses in brane scenarios which is independent of coordinate transformations. We apply our method to the scenario of Randall and Sundrum (RS) with two branes, which provides a solution to the hierarchy problem. The core of our proposal is the use of covariant equations and expressing all coordinate quantities in terms of invariant distances. In the RS model we find that massive brane fields propagate proper distances inversely proportional to masses that are not exponentially suppressed. The hierarchy between the gravitational and weak interactions is nevertheless preserved on the visible brane due to suppression of gravitational interactions on that brane. The towers of Kaluza-Klein states for bulk fields are observed to have different spacings on different branes when all masses are measured in units of the fundamental scale. Ratios of masses on each brane are the same in our covariant and the standard interpretations. Since masses of brane fields are not exponentiated, the fundamental scale of higher-dimensional gravity must be of the order of the weak scale.Comment: 14 page

Helical Tubes in Crowded Environments

When placed in a crowded environment, a semi-flexible tube is forced to fold so as to make a more compact shape. One compact shape that often arises in nature is the tight helix, especially when the tube thickness is of comparable size to the tube length. In this paper we use an excluded volume effect to model the effects of crowding. This gives us a measure of compactness for configurations of the tube, which we use to look at structures of the semi-flexible tube that minimize the excluded volume. We focus most of our attention on the helix and which helical geometries are most compact. We found that helices of specific pitch to radius ratio 2.512 to be optimally compact. This is the same geometry that minimizes the global curvature of the curve defining the tube. We further investigate the effects of adding a bending energy or multiple tubes to begin to explore the more complete space of possible geometries a tube could form.Comment: 10 page

Evaluating Dimethyldiethoxysilane for use in Polyurethane Crosslinked Silica Aerogels

Silica aerogels are highly porous materials which exhibit exceptionally low density and thermal conductivity. Their "pearl necklace" nanostructure, however, is inherently weak; most silica aerogels are brittle and fragile. The strength of aerogels can be improved by employing an additional crosslinking step using isocyanates. In this work, dimethyldiethoxysilane (DMDES) is evaluated for use in the silane backbone of polyurethane crosslinked aerogels. Approximately half of the resulting aerogels exhibited a core/shell morphology of hard crosslinked aerogel surrounding a softer, uncrosslinked center. Solid state NMR and scanning electron microscopy results indicate the DMDES incorporated itself as a conformal coating around the outside of the secondary silica particles, in much the same manner as isocyanate crosslinking. Response surface curves were generated from compression data, indicating levels of reinforcement comparable to that in previous literature, despite the core/shell morphology

Ideally embedded space-times

Due to the growing interest in embeddings of space-time in higher-dimensional spaces we consider a specific type of embedding. After proving an inequality between intrinsically defined curvature invariants and the squared mean curvature, we extend the notion of ideal embeddings from Riemannian geometry to the indefinite case. Ideal embeddings are such that the embedded manifold receives the least amount of tension from the surrounding space. Then it is shown that the de Sitter spaces, a Robertson-Walker space-time and some anisotropic perfect fluid metrics can be ideally embedded in a five-dimensional pseudo-Euclidean space.Comment: layout changed and typos corrected; uses revtex