Managing feline diabetes: current perspectives

Diabetes mellitus is a common endocrine disease in cats. While type 2 diabetes is the most common form seen in cats, other underlying causes may contribute to insulin resistance. Guidelines for diagnosis vary and often do not take into account prediabetic cats. The goals of treatment are to maximize the chance of remission, while minimizing the risks of hypoglycemia. This article presents a further overview of current treatment and monitoring recommendations for diabetic cats

Reply to Crawford et al.: Why Trap-Neuter-Return (TNR) Is an Ethical Solution for Stray Cat Management

The recently published article, ‘A Case of Letting the Cat out of the Bag—Why Trap-Neuter-Return Is Not an Ethical Solution for Stray Cat (Felis catus) Management,’ by Crawford et al. warrants rebuttal. The case presented in the paper, opposing the initiation of TNR trials in Australia, ignores peer-reviewed evidence which substantiates the effectiveness of TNR at reducing unowned urban cat numbers. In addition, the paper’s authors offer a number of unrealistic recommendations, which are little more than a rebranding of the failed status quo. Urban stray cats have long been considered a problem across Australia. Current practice calls for the trapping and killing of thousands of healthy urban stray cats and kittens each year with no apparent effect on the total population. In contrast, the literature offers numerous examples, including two recent studies in Australia, of reductions in urban stray cat numbers where TNR has been implemented. TNR has also been associated with reduced feline intake and euthanasia at shelters, which improves both animal welfare and the well-being of shelter staff. A large-scale trial of TNR in an urban Australian context is scientifically justified and long overdue

Risk factors for behavior problems in cats presented to an Australian companion animal behavior clinic

Behavior problems in companion animals are common reasons for relinquishment or euthanasia. Insight into the risk factors for problem behaviors will facilitate the construction of strategies for solutions. We identified risk factors for behavior problems in domestic cats whose owners contacted a companion animal behavior clinic in Brisbane, Australia. Owners of 1,556 cats reported on their cats' behavior problem, breed, sex and age, and owner's postcodes and work routine were also recorded. Risk factors were determined from proportional morbidities for the behavior problem that each cat was reported as having. Breed effects were also assessed by comparing the numbers of cats in each breed group with the breeds of registered cats in a part of the catchment area. Behavior problems in domestic cats where the owners sought professional advice were mostly (71% of all cats) related to house soiling, usually urination, and aggression, especially to familiar people. Persian and similar breeds were at reduced risk of aggression to familiar cats but increased risk of house soiling, compared to other breed groups. Overall, Persian, Siamese, Burmese, and similar breeds had more behavior problems than companion cat breeds. Older cats showed increasing tolerance of familiar people but reduced tolerance of other cats. Males were more likely to present with excessive vocalization and house soiling with urine and less likely to present with aggression between familiar cats. We conclude that cat breed, age and sex, and social advantage of the area in which the cat lives are risk factors for specific behavior problems

Measures of insulin sensitivity, leptin, and adiponectin concentrations in cats in diabetic remission compared to healthy control cats

ObjectivesFirstly, to compare differences in insulin, adiponectin, leptin, and measures of insulin sensitivity between diabetic cats in remission and healthy control cats, and determine whether these are predictors of diabetic relapse. Secondly, to determine if these hormones are associated with serum metabolites known to differ between groups. Thirdly, if any of the hormonal or identified metabolites are associated with measures of insulin sensitivity.AnimalsTwenty cats in diabetic remission for a median of 101 days, and 21 healthy matched control cats.MethodsA casual blood glucose measured on admission to the clinic. Following a 24 h fast, a fasted blood glucose was measured, and blood sample taken for hormone (i.e., insulin, leptin, and adiponectin) and untargeted metabolomic (GC-MS and LC-MS) analysis. A simplified IVGGT (1 g glucose/kg) was performed 3 h later. Cats were monitored for diabetes relapse for at least 9 months (270 days).ResultsCats in diabetic remission had significantly higher serum glucose and insulin concentrations, and decreased insulin sensitivity as indicated by an increase in HOMA and decrease in QUICKI and Bennett indices. Leptin was significantly increased, but there was no difference in adiponectin (or body condition score). Several significant correlations were found between insulin sensitivity indices, leptin, and serum metabolites identified as significantly different between remission and control cats. No metabolites were significantly correlated with adiponectin. No predictors of relapse were identified in this study.Conclusion and clinical importanceInsulin resistance, an underlying factor in diabetic cats, persists in diabetic remission. Cats in remission should be managed to avoid further exacerbating insulin resistance

Mapping of diabetes susceptibility LOCI in a domestic cat breed with an unusually high incidence of diabetes mellitus

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this by performing a genome-wide association scan on ABB cats. Four SNPs were associated with the ABB T2D phenotype with p values \u3c 0.005. All exons and splice junctions of candidate genes near significant single-nucleotide polymorphisms (SNPs) were sequenced, including the genes DGKG, IFG2BP2, SLC8A1, E2F6, ETV5, TRA2B and LIPH. Six candidate polymorphisms were followed up in a larger cohort of ABB cats with or without T2D and also in Burmese cats bred in America, which exhibit low T2D incidence. The original SNPs were confirmed in this cohort as associated with the T2D phenotype, although no novel coding SNPs in any of the seven candidate genes showed association with T2D. The identification of genetic markers associated with T2D susceptibility in ABB cats will enable preventative health strategies and guide breeding programs to reduce the prevalence of T2D in these cats

Mapping of diabetes susceptibility LOCI in a domestic cat breed with an unusually high incidence of diabetes mellitus

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this by performing a genome-wide association scan on ABB cats. Four SNPs were associated with the ABB T2D phenotype with p values \u3c 0.005. All exons and splice junctions of candidate genes near significant single-nucleotide polymorphisms (SNPs) were sequenced, including the genes DGKG, IFG2BP2, SLC8A1, E2F6, ETV5, TRA2B and LIPH. Six candidate polymorphisms were followed up in a larger cohort of ABB cats with or without T2D and also in Burmese cats bred in America, which exhibit low T2D incidence. The original SNPs were confirmed in this cohort as associated with the T2D phenotype, although no novel coding SNPs in any of the seven candidate genes showed association with T2D. The identification of genetic markers associated with T2D susceptibility in ABB cats will enable preventative health strategies and guide breeding programs to reduce the prevalence of T2D in these cats

Problem-Based Feline Medicine

This focused resource covers all medical conditions that affect cats. Using a unique problem-based approach, it provides essential information for assessing presenting symptoms, reaching a differential diagnosis, and selecting the appropriate course of treatment for feline patients. A consistent format makes it easy to find information related to key signs and possible causative factors (graded to indicate how common each is), diagnosis, differential diagnosis (including tests where appropriate), treatment, prognosis, and prevention (where applicable) for each clinical condition. Unique problem-based approach discusses how to make a problem-based diagnosis. Concise, logical format makes this resource ideal for quick reference in the clinical setting. Covers every condition likely to be encountered in cats worldwide. Features a strong international contributor list of feline experts from North America, UK, Europe, and Australia A comprehensive drug formulary lists all drug treatments available for cats. A separate chapter on drugs in cats lists the problems veterinarians might encounter due to differences in feline metabolism

Public opinions on strategies for managing stray cats and predictors of opposition to trap-neuter and return in Brisbane, Australia

A survey of Brisbane residents was undertaken to investigate community attitudes toward urban stray cats and their management. Surveys were distributed to 84 medical and dental practices across Brisbane City, and were completed by 305 patients and staff. Practices were targeted to achieve a sample of respondents from a representative distribution of socioeconomic backgrounds. After being informed about trap, neuter, and return (TNR) programs for management of urban stray cats, most respondents (79%), chose TNR as their preferred management strategy, while a lesser proportion (18%) expressed a preference to continue the current Brisbane City Council lethal control program (catching and culling ~1,000 cats annually), and 3.4% selected to leave the cats alone. Differences in beliefs and attitudes toward urban stray cats as a function of demographic variables were investigated. Statistical analyses indicated that respondents who were male, older, non-cat owners, those who believed euthanasia of stray cats was humane, and that urban stray cats spread disease to humans were significantly more likely to express a preference for lethal control, as opposed to non-lethal population management. Based on these findings, we recommend that information is disseminated to mitigate these concerns or negative beliefs, where warranted. Ultimately, findings from this study demonstrate that current Queensland legislation does not reflect public views and opinions on stray cat management and should be reviewed. Formal research evaluating the efficacy of TNR programs for urban stray cats in Australia would be in the public interest