Liposomes in Biology and Medicine

Drug delivery systems (DDS) have become important tools for the specific delivery of a large number of drug molecules. Since their discovery in the 1960s liposomes were recognized as models to study biological membranes and as versatile DDS of both hydrophilic and lipophilic molecules. Liposomes--nanosized unilamellar phospholipid bilayer vesicles--undoubtedly represent the most extensively studied and advanced drug delivery vehicles. After a long period of research and development efforts, liposome-formulated drugs have now entered the clinics to treat cancer and systemic or local fungal infections, mainly because they are biologically inert and biocompatible and practically do not cause unwanted toxic or antigenic reactions. A novel, up-coming and promising therapy approach for the treatment of solid tumors is the depletion of macrophages, particularly tumor associated macrophages with bisphosphonate-containing liposomes. In the advent of the use of genetic material as therapeutic molecules the development of delivery systems to target such novel drug molecules to cells or to target organs becomes increasingly important. Liposomes, in particular lipid-DNA complexes termed lipoplexes, compete successfully with viral gene transfection systems in this field of application. Future DDS will mostly be based on protein, peptide and DNA therapeutics and their next generation analogs and derivatives. Due to their versatility and vast body of known properties liposome-based formulations will continue to occupy a leading role among the large selection of emerging DDS

Human Resource Flexibility as a Mediating Variable Between High Performance Work Systems and Performance

Much of the human resource management literature has demonstrated the impact of high performance work systems (HPWS) on organizational performance. A new generation of studies is emerging in this literature that recommends the inclusion of mediating variables between HPWS and organizational performance. The increasing rate of dynamism in competitive environments suggests that measures of employee adaptability should be included as a mechanism that may explain the relevance of HPWS to firm competitiveness. On a sample of 226 Spanish firms, the study’s results confirm that HPWS influences performance through its impact on the firm’s human resource (HR) flexibility

The hydrothermal synthesis of silicalite - an in situ small-angle neutron scattering study

Small-angle neutron scattering was used to study in situ the gel transformations occurring in the amorphous zeolite reaction mixt. during the so-called induction period and subsequent crystn. The synthesis of silicalite was studied at various temps. (130, 150, 170, 190 Deg). The size of the primary units in the precursor reaction mixt. is .apprx.45 .ANG.. These units grow during the synthesis. The largest particle sizes were obtained at the lowest temps. owing to the smaller nucleation rate. Before crystn. can occur, a reorganization of the gel phase occurs. During the induction period as well as during the crystn. the gel units have a surface fractal structure. Crystn. starts in or on the growing amorphous gel particles. [on SciFinder (R)

Late Holocene vegetation and palaeoenvironmental history of the Dunadd area, Argyll, Scotland: chronology of events

This paper focuses on the chronology and environmental significance of a sediment sequence from an alluvial locality in the vicinity of the historic site of Dunadd, Scotland. It outlines the rationale and statistical validity of an age model derived for a sequence of floodplain sediments from which detailed pollen-stratigraphical and plant macrofossil records have been derived. A series of radiocarbon dates are calibrated using a Bayesian modelling approach, the results of which can be refined by incorporating two independent age estimates based on tephra layers of known age. Analysis of the entire floodplain sequence for volcanic glass shards revealed the presence of discrete but geochemically very similar tephra layers within the upper (late Holocene) part of the sequence. Comparison with published geochemical data obtained from Icelandic tephras of historical age indicates strong statistical correlations with the Hekla 1947 AD and Hekla 1510 AD. While the Hekla 1510 AD tephra has previously been reported from sites within Britain and Ireland, the Dunadd sequence affords the first record of the Hekla 1947 AD tephra layer within Scotland. When the ages and stratigraphic positions of both tephra layers are incorporated into the Bayesian age model, an overall centennial to decadal precision for the late Holocene is achieved, with archaeological and environmental transitions discriminated with highest-likelihood age uncertainty ranges of 20–50 years at 95% confidence. The local environmental record is assessed in the light of this new chronological framework: the data support previously reported proposals for two periods of significant climatic deterioration with increased wetness, the first during the early Medieval period and the second during the late 16th and 17th centuries AD

Anticipated and Adaptive Prediction in Functional Discriminant Analysis

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