Langerhans Cell Histiocytosis in the Occipital Condyle: A Case Study and a Brief Review of the Literature

We present a case study of a 5-year-old patient, who presented with left-sided torticollis. Due to persistence of problems, a CT and an MRI were made showing a single osteolytic lesion centred on right occipital condyle. After an open biopsy, histology confirmed it to be Langerhans cell histiocytosis (LCH). Torticollis or restricted range of motion is a presenting feature in 76% of children with LCH with cervical involvement. There remains much debate on the best treatment strategy. The clinical and radiological outcomes of the case study presented on this article support the treatment of LCH with chemotherapy in cases with solitary involvement of the occipital condyle.info:eu-repo/semantics/publishedVersio

Usage And Efficacy Of Social Media Marketing Tools: An Investigation Of College Age Student’s Behaviors

This study looks at social media marketing techniques used by the world’s top companies to determine their effectiveness on college age consumers. Social media use is becoming increasingly important with the advent of social media platforms such as Facebook and Twitter. This research first defines the social media marketing strategies done on social media, and then measures the effectiveness of each strategy on college students. This research also attempts to see if there is a relationship between personality and the effectiveness of certain social media marketing strategies

The early compositions for cello and piano by Heitor Villa-Lobos

This study presents a historical overview of Heitor Villa-Lobos’s early life, career, surrounding environment, influences, selected early compositions for cello and piano written between 1913 and 1917, autographs, and of Rio de Janeiro from the late 19th and early 20th centuries. In the study of Villa-Lobos’s early life and Rio de Janeiro from the late 19th and early 20th centuries, it is important to consider the influences of Europe, especially France on Brazil, and European composers on Heitor Villa-Lobos. This study provides historical information, and attempts to increase the dissemination of Villa-Lobos’s early compositions for cello and piano into the standard cello repertoire. The study also presents information to help cellists understand and then incorporate these pieces into their repertoire, followed by a recording of selected Villa-Lobos’s early compositions for cello and piano performed by this author. More pertinent materials are given in the appendixes, such as historical information about the other compositions for cello and piano written between 1913 and 1917 (Appendix A), and a complete list of compositions for and with cello by Heitor Villa-Lobos (Appendix B). The findings of this study show that Villa-Lobos’s early compositions for cello and piano show a complete absence of elements of Brazilian folklore, were highly influenced by the aesthetics of European composers in vogue at the time in Brazil, and were written while the composer was active as a cellist As shown in the Conclusion, after careful analysis, it can be inferred that Villa-Lobos’s early compositions for cello and piano deserve to be known, incorporated into the repertoire of modern cellists, and performed more frequently

A potential role for naringenin in reversing tamoxifen resistance in MCF-7 breast cancer cells

Tamoxifen has been used as an effective treatment against breast cancer for over 30 years. However, tamoxifen resistance has become a major hurdle to effective treatment. Previous studies have implicated up-regulation of the PI3K and MAPK pathways as being involved in the growth exhibited by tamoxifen resistant cells. Data from our lab and others have shown naringenin to have the ability to impair both of these signaling pathways. For this study, I investigated whether naringenin, a flavanone, could reverse the proliferation observed in tamoxifen-resistant cells (TAM-R). MCF-7 cells were exposed to low levels of 4-OH-tamoxifen (1 µM) for 10 months in order to generate a tamoxifen-resistant cell line, TAM-R. These cells were then cultured under various combinations of treatment with tamoxifen and naringenin. TAM-R cells demonstrated a clear ability to proliferate in the presence of tamoxifen as measured using cell counting and an MTT assay. However, the addition of naringenin reversed that proliferation. The TAM-R cells also exhibited an up-regulation of the MAPK pathway which was also reversed by treatment with naringenin as measured by western blot analysis. In addition, treatment with tamoxifen and naringenin together led to a greater reduction in cell growth than either treatment alone. Confocal microscopy was also employed to look for any changes in the localization patterns of the estrogen receptor alpha (ERα). ERα was found predominantly in the nucleus in MCF-7 cells. Upon treatment with tamoxifen, this pattern changed to a peri-nuclear localization. Once the cells attained tamoxifen resistance, the ERα displayed an even pattern across the cell. However, upon treatment of the TAM-R cells with naringenin, the ERα localization returned to a peri-nuclear pattern similar to that seen in the tamoxifen-sensitive cells. The results from this study clearly demonstrate the ability of naringenin to reverse the proliferation normally seen in TAM-R cells. Naringenin also appears to have a synergistic effect with tamoxifen on growth impairment. There is also evidence these changes are taking place through the MAPK pathway. Taken together, these results open up the possibility of treatment with naringenin as a means to combat tamoxifen resistance

Bridging identities : solo oboe and chamber works by Mexican composers

I. Solo Recital: Saturday, October 17, 2020, 5:30 p.m, Tew Recital Hall. Oboe Concerto: Rondo Pastorale, Finale (Scherzo) (Ralph Vaughan Williams); Obsession (Makoto Shinohara); Brokenvention (Alyssa Morris); Spell Song (Toshio Hosokawa); Italian Dance (Madeleine Dring). II. Solo Recital: Tuesday, April 13, 2021, 7:30 p.m, Tew Recital Hall. Sueños de Crisálida (Allesandra Vargas), Oboe Concerto in a minor, RV 461 (Antonio Vivaldi), Oboe Concerto: Allegro Moderato quasi Pastorale, Adagio (David Mullikin); Summer Song (Miguel del Águila). III. Solo Recital: Sunday, April 24, 2022, 11:30 a.m, Tew Recital Hall. Al filo del agua (Maria Granillo); Night Windows: Anger, Nostalgia (Thea Musgrave); Boca abajo (Francisco Cortés-Álvarez); Parking Violation: 42nd Street and Queens Boulevard, West Broadway & Franklin Street, 42nd Street & Greenpoint Avenue, 96th Street & Broadway, 42nd Street & 47th Avenue (Mark Mellits); Danza de Mediodía (Arturo Márquez). IV. D.M.A Research Project. BRIDGING IDENTITIES: SOLO OBOE AND CHAMBER WORKS BY MEXICAN COMPOSERS, (2023). The purpose of this project was to make known various oboe solo and chamber works by Mexican composers and to establish the beginnings of a communications network between oboists and these same composers. For each of the ten pieces in the dissertation a performance analysis was conducted and a playing level assigned. Composers were introduced via biographies and transcribed interviews. The following questions were addressed in this project. How many pieces for the oboe by Mexican composers exist? Is there a resource to search for these compositions other than a blind internet search? How do I obtain the music for these pieces? What oboe techniques are needed to perform these pieces? As the project was conducted and pieces compiled, other than two albums dedicated to oboe works by Mexican composers, Carmen Thierry’s Oboemia: Música Mexicana para Oboe Solo and Jonathan Thompsons’ Tollan: Mexican Works for the Oboe, three other resources found were found. Two of these are student theses which also focused on oboe works by Mexican composers, Alejandra Odgers’ La Música de Cámara Para Oboe Escrita En La Segunda Mitad Del Siglo XX, and Mireya Pérez Fernández’s Música Mexicana Inédita Para Oboe. Grabación Digital, Comentarios Analíticos Y Partituras. The third resource is a catalog of Mexican oboe works, Catalog of Mexican Oboe Music, compiled by oboist Jonathan Thompson. However, since the theses were discovered in the middle of the project and the catalog was only acquired towards the end of the project, all pieces included in the dissertation were found in two albums mentioned above or via individual internet searches. Music was obtained mostly by contacting the composers directly; only five out of ten pieces were procured in separate publishing websites. There are a variety of extended oboe techniques needed for these pieces as well. These include glissandi, pitch bending, quarter tones and micro tones, flutter tonguing, multiphonics, tremolos, and double tonguing

Regularity of Edge Ideals and Their Powers

We survey recent studies on the Castelnuovo-Mumford regularity of edge ideals of graphs and their powers. Our focus is on bounds and exact values of $\text{ reg } I(G)$ and the asymptotic linear function $\text{ reg } I(G)^q$, for $q \geq 1,$ in terms of combinatorial data of the given graph $G.$Comment: 31 pages, 15 figure

Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection?

Indexación: Web of Science.Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. cruzi Calreticulin (TcCRT), an endoplasmic reticulum-resident chaperone, translocated-externalized by the parasite, may mediate at least an important part of this effect. Thus, recombinant TcCRT (rTcCRT) has important in vivo antiangiogenic and antitumor activities. However, the relevant question whether the in vivo antitumor effect of T. cruzi infection is indeed mediated by the native chaperone (nTcCRT), remains open. Herein, by using specific modified anti-rTcCRT antibodies (Abs), we have neutralized the antitumor activity of T. cruzi infection and extracts thereof, thus identifying nTcCRT as a valid mediator of this effect. Methods: Polyclonal anti-rTcCRT F(ab')(2) Ab fragments were used to reverse the capacity of rTcCRT to inhibit EAhy926 endothelial cell (EC) proliferation, as detected by BrdU uptake. Using these F(ab')(2) fragments, we also challenged the capacity of nTcCRT, during T. cruzi infection, to inhibit the growth of an aggressive mammary adenocarcinoma cell line (TA3-MTXR) in mice. Moreover, we determined the capacity of anti-rTcCRT Abs to reverse the antitumor effect of an epimastigote extract (EE). Finally, the effects of these treatments on tumor histology were evaluated. Results: The rTcCRT capacity to inhibit ECs proliferation was reversed by anti-rTcCRT F(ab')(2) Ab fragments, thus defining them as valid probes to interfere in vivo with this important TcCRT function. Consequently, during infection, these Ab fragments also reversed the in vivo experimental mammary tumor growth. Moreover, anti-rTcCRT Abs also neutralized the antitumor effect of an EE, again identifying the chaperone protein as an important mediator of this anti mammary tumor effect. Finally, as determined by conventional histological parameters, in infected animals and in those treated with EE, less invasive tumors were observed while, as expected, treatment with F(ab')(2) Ab fragments increased malignancy. Conclusion: We have identified translocated/externalized nTcCRT as responsible for at least an important part of the anti mammary tumor effect of the chaperone observed during experimental infections with T. cruzi.http://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2764-

Investigating the effectiveness and feasibility of exercise on microvascular reactivity and quality of life in systemic sclerosis patients: study protocol for a feasibility study

Background: Raynaud’s phenomenon is one of the first clinical manifestations observed in systemic sclerosis (SSc). This microvasculature disorder affects mostly the digits in over 95% of SSc patients, significantly affecting their healthrelated quality of life (HRQoL) and incurring higher hospital admissions and other healthcare costs. Exercise is known to improve both micro- and macrovascular function – aerobic exercise and resistance training, separately or combined, have been demonstrated to lead to significant vasculo-physiological improvements in conditions that present vasculopathy. However, the effects of a combined exercise programme on microcirculation in SSc patients has yet to be investigated. Therefore, the purpose of this study is to assess the effects of high-intensity interval training (HIIT) combined with circuit resistance training on the microvascular function in the digital area of SSc patients. Methods: This will be a randomised controlled, feasibility trial with two arms, wherein 30 patients with SSc in receipt of medical treatment will be randomly assigned to usual care (medical treatment) or to a 12-week supervised exercise programme. Patients in the exercise group will undertake two, 45-min sessions each week consisting of 30 min HIIT (30 s 100% peak power output/30 s passive recovery) on the arm crank ergometer and 15 min of upper body circuit resistance training. Patients will be assessed before as well as at 3 and 6 months following randomisation. Primary outcomes of the study will be recruitment and retention rate, intervention acceptability and adherence to the exercise programme. Secondary outcomes include the digital area cutaneous microvascular function (laser Doppler fluximetry combined with iontophoresis), physical fitness, functional ability, upper back transcutaneous oxygen tension, body composition and quality of life (EQ-5D-5L). Selected interviews with a subsample of patients will be undertaken to explore their experiences of having Raynaud’s phenomenon and the acceptability of the exercise intervention and study procedures. Discussion: Data from this study will be used to identify the feasibility of a combined exercise programme to be implemented in SSc patients, the acceptability of the intervention and the study design, and to determine the effects of exercise on the microvasculature. Overall, this study will provide sufficient data to inform and support a full multicentre clinical trial