Negative index metamaterial-based frequency-reconfigurable textile cpw antenna for microwave imaging of breast cancer

In this paper, we report the design and development of a metamaterial (MTM)-based di�rectional coplanar waveguide (CPW)-fed reconfigurable textile antenna using radiofrequency (RF) varactor diodes for microwave breast imaging. Both simulation and measurement results of the proposed MTM-based CPW-fed reconfigurable textile antenna revealed a continuous frequency re�configuration to a distinct frequency band between 2.42 GHz and 3.2 GHz with a frequency ratio of 2.33:1, and with a static bandwidth at 4–15 GHz. The results also indicated that directional radiation pattern could be produced at the frequency reconfigurable region and the antenna had a peak gain of 7.56 dBi with an average efficiency of more than 67%. The MTM-based reconfigurable antenna was also tested under the deformed condition and analysed in the vicinity of the breast phantom. This microwave imaging system was used to perform simulation and measurement experiments on a custom-fabricated realistic breast phantom with heterogeneous tissue composition with image reconstruction using delay-and-sum (DAS) and delay-multiply-and-sum (DMAS) algorithms. Given that the MWI system was capable of detecting a cancer as small as 10 mm in the breast phan�tom, we propose that this technique may be used clinically for the detection of breast cancer

Author Correction:C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-40779-9, published online 17 August 2023

GENOME-WIDE SCREEN FOR REGULATORS FOR TERT TRANSCRIPTION

Ph.DDOCTOR OF PHILOSOPH

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely. Telomerase Reverse Transcriptase (TERT), the catalytic subunit of telomerase holoenzyme, is the rate-limiting factor in reconstituting telomerase activity in vivo. To date, the expression and function of the human Telomerase Reverse Transcriptase (hTERT) gene are known to be regulated at various molecular levels (including genetic, mRNA, protein and subcellular localization) by a number of diverse factors. Among these means of regulation, transcription modulation is the most important, as evident in its tight regulation in cancer cell survival as well as pluripotent stem cell maintenance and differentiation. Here, we discuss how hTERT gene transcription is regulated, mainly focusing on the contribution of trans-acting factors such as transcription factors and epigenetic modifiers, as well as genetic alterations in hTERT proximal promoter

Biomechanical evaluation of locking compression plate (LCP) versus dynamic compression plate (DCP): A finite element analysis

Internal fixators are commonly used to treat long bone fractures, its aim is to provide interfragmentary compression, allow limited micromotion and provide stability to the bone for ambulation. However, complications such as non-unions, malunions and broken implant, can occur due to the complexity of mechanical force acting on the bone-plate models. Therefore, this study is proposed to investigate the biomechanical characterization of plate design on a tibia bone using finite element method. Two different designs, 1) locking compression plate (LCP) and dynamic compression plate (DCP) were simulated by using Marc.Mentat software. From the findings, the LCP have lower peak von Mises stress (VMS) distribution of 160 MPa compared to DCP with VMS value of 232 MPa. Surprisingly, the VMS of DCP plate system have exceed the yield strength of stainless steel (215 MPa) which translate to higher risk of failures. Moreover, the DCP plate system shows 50% lower stability compared to the LCP plate system, which has the peak displacement at 0.98 mm compared to the DCP bone at 1.53 mm. In conclusion, the LCP provides better stability and stress distribution up to 45% differences as compared to the DCP

The efficiency of Islamic Banking: Bibliometric Analysis

Because interest-free financing is so important in Islamic banking, practitioners have created an innovative environment in which an alternative to interest is expected. As a result, the title of this study is bibliometric analysis of the efficiency Islamic banking, and the method used for this study is bibliometric analysis. The main reason for choosing this phrase is that it is relevant to the current study topic of Islamic banking and finance. There are several research objectives that have been identified that have led to this research, which are to investigate the current trend and structure of research on efficiency in the Islamic banking industry, to identify the most studied themes within the Islamic banking efficiency literature, and to determine how far prior research has discovered about the level of efficiency in the Islamic banking industry worldwide. This analysis employs the method of document analysis by gathering data from previous studies that are bibliometric. Because we conduct bibliometric research, the framework of methods used to obtain the article is included among the research questions, research objectives, and analysis techniques. We used Scopus, a multidisciplinary database suitable for information systems (IS) researchers, to find past research articles on the efficiency of Islamic banking. We chose two citations: co-occurrence and co-citation. Researchers use co-occurrence to find the most frequently used keywords in articles about the efficiency of Islamic banking, and o-citation is the frequency of using articles about the efficiency of Islamic banking in the top 16 countries. The innovation aspect of Islamic banking products or technologies plays an important role in improving the efficiency of Islamic banking

Histone H3 K27 acetylation marks a potent enhancer element on the adipogenic master regulator gene Pparg2

<div><p>PPARγ2 is expressed almost exclusively in adipose tissue and plays a central role in adipogenesis. Despite intensive studies over the last 2 decades, the mechanism regulating the expression of the Pparg2 gene, especially the role of cis-regulatory elements, is still not completely understood. Here, we report a comprehensive investigation of the enhancer elements within the murine Pparg2 gene. Utilizing the combined techniques of sequence conservation analysis and chromatin marker examination, we identified a potent enhancer element that augmented the expression of a reporter gene under the control of the Pparg2 promoter by 20-fold. This enhancer element was first identified as highly conserved non-coding sequence 10 (CNS10) and was later shown to be enriched with the enhancer marker H3 K27 acetylation. Further studies identified a binding site for p300 as the essential enhancer element in CNS10. Moreover, p300 physically binds to CNS10 and is required for the enhancer activity of CNS10. The depletion of p300 by siRNA resulted in significantly impaired activation of Pparg2 at the early stages of 3T3-L1 adipogenesis. In summary, our study identified a novel enhancer element on the murine Pparg2 gene and suggested a novel mechanism for the regulation of Pparg2 expression by p300 in 3T3-L1 adipogenesis.</p></div

C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption

Abstract While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR) is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are poorly defined. To inform on these mechanisms we conducted a genome-wide screen for genes that are synthetic lethal with PARP1/2 gene disruption and identified C16orf72/HAPSTR1/TAPR1 as a novel modulator of replication-associated R-loops. C16orf72 is critical to facilitate replication fork restart, suppress DNA damage and maintain genome stability in response to replication stress. Importantly, C16orf72 and PARP1/2 function in parallel pathways to suppress DNA:RNA hybrids that accumulate at stalled replication forks. Mechanistically, this is achieved through an interaction of C16orf72 with BRCA1 and the RNA/DNA helicase Senataxin to facilitate their recruitment to RNA:DNA hybrids and confer resistance to PARP inhibitors. Together, this identifies a C16orf72/Senataxin/BRCA1-dependent pathway to suppress replication-associated R-loop accumulation, maintain genome stability and confer resistance to PARP inhibitors