Bargaining and Search: An Experimental Study

We study experimentally two versions of a model in which a buyer and a seller bargain over the price of a good; however, the buyer can choose to leave the negotiation table to search for other alternatives. Under one version, if the buyer chooses to search for a better price, the opportunity to purchase the good at the stated price is gone. Under the second version, the seller guarantees the same price if the buyer chooses to return immediately after a search (presumably because a better price could not be found). In both cases, the buyer has a fairly good idea about what to expect from the search, but because the search is costly, he has to weigh the potential benefits of the search against its cost. It turns out (theoretically) that adding search to a simple bargaining mechanism eliminates some unsatisfactory features of bargaining theory. Our experiment reveals that the model can account for some (but not all) of the behavioral regularities. In line with recent developments in behavioral decision theory and game theory, which assume bounded rationality and preferences over the relative division of a surplus, we find that subjects follow simple rules of thumb and distributional norms in choosing strategies, which are reflected in the behavioral consistencies observed in this study.Bargaining, search, outside option, ultimatum game

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile

Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors. Yet, allosteric inhibition of FXIIIa is a paradigm that may offer a key advantage of controlled inhibition over orthosteric inhibition. Such an approach is likely to lead to novel FXIIIa inhibitors that do not carry bleeding risks. We reasoned that targeting a collection of basic amino acid residues distant from FXIIIa’s active site by using sulfated glycosaminoglycans (GAGs) or non-saccharide GAG mimetics (NSGMs) would lead to the discovery of the first allosteric FXIIIa inhibitors. We tested a library of 22 variably sulfated GAGs and NSGMs against human FXIIIa to discover promising hits. Interestingly, although some GAGs bound to FXIIIa better than NSGMs, no GAG displayed any inhibition. An undecasulfated quercetin analog was found to inhibit FXIIIa with reasonable potency (efficacy of 98%). Michaelis-Menten kinetic studies revealed an allosteric mechanism of inhibition. Fluorescence studies confirmed close correspondence between binding affinity and inhibition potency, as expected for an allosteric process. The inhibitor was reversible and at least 9-fold- and 26-fold selective over two GAG-binding proteins factor Xa (efficacy of 71%) and thrombin, respectively, and at least 27-fold selective over a cysteine protease papain. The inhibitor also inhibited the FXIIIa-mediated polymerization of fibrin in vitro. Overall, our work presents the proof-of-principle that FXIIIa can be allosterically modulated by sulfated non-saccharide agents much smaller than GAGs, which should enable the design of selective and safe anticoagulants

Recommendation for Creep and Creep-fatigue assessment for P91 Components

This report is based on the results and experience gained in assessing both public domain and MATTER data, some previously reported in the MATTER deliverable D4.5: “Creep-fatigue interaction rules for P91” and some assessed here. A number of methods, including interaction diagram based methods and simplified methods, have been compared for predicting the creep-fatigue life of P91 steel. The effect of cyclic softening on creep properties have been considered in the evaluations presented in this report. The purpose of this report is to give recommendations for creep and creep-fatigue assessment for components made of X10CrMoVNb9-1 (P91) steel. Based on the conclusions of the assessments the following recommendations are given: 1.The creep properties of P91 steel suffer from cyclic loading and it is recommended that the current RCC-MRx creep strain equations should be modified or replaced by a model that can implement time factors or stress reduction factors to correct for softening. Suitable models have been identified. The softening of P91 potentially causes unconservativeness in significant creep conditions where accumulated strain is a limiting design factor. 2.The interaction diagram models currently applied in design codes are complicated to apply and include several complex modelling challenges. It has been recommended that alternative modelling concepts, such as using simplified models should be considered for use in design codes. The simplified models optimized for P91 have been shown to give good and robust predictions on cycles to failure. 3.Currently available P91 data mainly consists of large strain range and short hold period data, where creep is mainly causing additional strain. Data with verified creep cavitation damage is limited or totally lacking. It is recommended that more data is generated at low strain ranges and long hold times to improve long term extrapolation robustness. Tensile property data for softened material is also needed to determine the stress range where power-law breakdown behaviour in creep can be expected and to improve the understanding of the long term microstructural evolution in cyclic service.JRC.F.4-Innovative Technologies for Nuclear Reactor Safet

Stopping and Isospin Equilibration in Heavy Ion Collisions

We investigate the density behaviour of the symmetry energy with respect to isospin equilibration in the combined systems $Ru(Zr)+Zr(Ru)$ at relativistic energies of 0.4 and $1.528 AGeV$. The study is performed within a relativistic framework and the contribution of the iso-vector, scalar $\delta$ field to the symmetry energy and the isospin dynamics is particularly explored. We find that the isospin mixing depends on the symmetry energy and a stiff behaviour leads to more transparency. The results are also nicely sensitive to the "fine structure" of the symmetry energy, i.e. to the covariant properties of the isovector meson fields. The isospin tracing appears much less dependent on the in-medium neutron-proton cross-sections ($\sigma_{np}$) and this makes such observable very peculiar for the study of the isovector part of the nuclear equation of state. Within such a framework, comparisons with experiments support the introduction of the $\delta$ meson in the description of the iso-vector equation of state.Comment: 11 pages, 5 figures. Accepted for publication in Phys.Lett.

Probing the Isospin Dependent In-Medium Nucleon-Nucleon Cross Section by Nucleon Emissions

The effects of the symmetry potential and the isospin dependent in-medium nucleon-nucleon (NN) cross section on the number of proton(neutron) emissions N$_p(N_n$) are studied respectively within an isospin-dependent quantum molecular dynamics (IQMD) model. The isospin dependent in-medium NN cross section is found to have a strong influence on N$_p(N_n$) but N$_p(N_n$) is not sensitive to the symmetry potential for the neutron-deficient colliding system at relatively high energies.We propose to make use of the N$_p(N_n$) as a probe to extract information on the isospin dependent in-medium NN cross section.Comment: 7 pages,3 figure

Centrality dependence of charged-particle pseudorapidity distributions from d+Au collisions at sqrt(s_{NN})=200 GeV

Charged-particle pseudorapidity densities are presented for the d+Au reaction at sqrt{s_{NN}}=200 GeV with -4.2 <= eta <= 4.2$. The results, from the BRAHMS experiment at RHIC, are shown for minimum-bias events and 0-30%, 30-60%, and 60-80% centrality classes. Models incorporating both soft physics and hard, perturbative QCD-based scattering physics agree well with the experimental results. The data do not support predictions based on strong-coupling, semi-classical QCD. In the deuteron-fragmentation region the central 200 GeV data show behavior similar to full-overlap d+Au results at sqrt{s_{NN}}=19.4 GeV.Comment: 4 pages, 3figures; expanded discussion of uncertainties; added 60-80% centrality range; added additional discussion on centrality selection bia

Scanning the phases of QCD with BRAHMS

BRAHMS has the ability to study relativistic heavy ion collisions from the final freeze-out of hadrons all the way back to the initial wave-function of the gold nuclei. This is accomplished by studying hadrons with a very wide range of momenta and angles. In doing so we can scan various phases of QCD, from a hadron gas, to a quark gluon plasma and perhaps to a color glass condensate.Comment: 8 pages, 6 figures, proceedings of plenary talk at Quark Matter 2004 conferenc

High Pt Hadron Spectra at High Rapidity

We report the measurement of charged hadron production at different pseudo-rapidity values in deuteron+gold as well as proton+proton collisions at $sqrt{s_{NN}}$ = 200GeV at RHIC. The nuclear modification factors $R_{dAu}$ and $R_{cp}$ are used to investigate new behaviors in the deuteron+gold system as function of rapidity and the centrality of the collisions respectively.Comment: Nine pages 4 figures to be published in the QM2004 Proceedings, typos corrected and one reference adde