The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT1–7), each with several subpopulations, have been identified for serotonin, which are different in terms of localization and downstream signaling. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, γ-aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory. In addition,there has been an alteration in the density of serotonergic receptors in aging and Alzheimer’s disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. Here, we discuss the serotonin-induced modulation of various systems involved in mnesic function including cholinergic, dopaminergic, GABAergic, glutamatergic transmissions as well as amyloidogenesis and intracellular pathways

Sanyar Video Laryngoscope Improved Time and First Pass Success of Tracheal Intubation in Intensive Care Unit in Compared to Direct Laryngoscopy

Background: Airway management and tracheal intubation in the ICU is a difficult procedure that may be concomitant with major complications. The purpose of this study was to evaluate the effect of the SANYAR ® video laryngoscope(S-VL) on laryngeal view and first Pass Success of tracheal Intubation compared with direct laryngoscopy. Methods: This comparative, prospective clinical study was conducted on 120 adult patients in a single-center, in a surgical ICU under the supervision of an anesthesiologist in a university hospital. Difficult airway predictors, glottic view, first Pass Success of tracheal Intubation and time of intubation were evaluated with Macintosh laryngoscopy (ML) or the SANYAR® Video Laryngoscope(S-VL). Results: Tracheal intubation was performed in 58 critically ill patients using ML and 62 patients using S-VL. According to Cormack and Lehane (C&L) grading glottic visualization was more difficult using ML (41%, C&L grade 3 and 4) compared with S-VL (13%, C&L grade 3 and 4) p<0.001. Intubation of trachea was more successful in the first attempt, in patients with at least one difficult airway predictor with a S-VL compared to ML (87% vs. 38%; P = 0.001), time of intubation was also shorter by using S-VL. Conclusion: Among critically ill patients in the intensive care unit, who require intubation, the SANYAR video laryngoscopy improved glottis view compared to the Macintosh direct laryngoscopy and first-pass orotracheal intubation rate especially in patients with potentially difficult airways

Effect of Genistein and L-Carnitine and Their Combination on Gene Expression of Hepatocyte HMG-COA Reductase and LDL Receptor in Experimental Nephrotic Syndrome

Background: Nephrotic syndrome is a disorder that leads to hyperlipidemia. L-carnitine and genistein can effect on lipid metabolism and the syndrome. In the present study, we have delved into the separate and the twin-effects of L-carnitine and genistein on the gene expressions of HMG-COA reductase and LDL receptor in experimental nephrotic syndrome. Methods: In this controlled experimental study, 50 male Sprague–Dawley rats were randomly divided into five groups: NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), LCG (L-carnitine-genistein). Adri-amycin was used for inducing nephrotic syndrome and the spot urine samples and urine protein-to-creatinine ratio were measured. Hepatocytic RNA was extracted and real-time PCR was used for HMG-COA Reductase and LDL receptor gene Expression measurement. Results: The final weight of the patients groups were lower than the NC group (P=0.001), and weight gain of the NC group was higher than the other groups (P<0.001). The proteinuria and urine protein-to-creatinine ratio showed sig-nificant differences between PC group and LC, G and LCG groups at week 7 (P<0.001). The expression of HMG-COA Reductase mRNA down regulated in LC, G and LCG groups in comparison with PC group (P<0.001). ΔCT of LDLr mRNA showed significant differences between the PC group and the other patient groups (P<0.001). Conclusion: This study shows a significant decreasing (P<0.001) and non-significant increasing trend in HMG-COA Reductase and LDLr gene expression, respectively, and synergistic effect of L-carnitine and genistein on these genes in experimental nephrotic syndrome

Evaluation of leishmanicidal effect of Euphorbia petiolata extract by in vivo anti-leishmanial assay using promastigotes of Leishmania major

Objective: The extract of different species of Euphorbia has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the in vitro leishmanicidal effect of Euphorbia petiolata (E. petiolata) extract. Materials and Methods: Ethanolic percolated and methanolic Soxhlet extract of E. petiolata on promastigotes of L. major at different concentrations of extracts, one positive control group and one negative control group as well as 1 solvent control were prepared and placed in 24-well plates that contained 40,000 parasites/well. Afterwards, plates were incubated at 25 ˚C for six days and number of parasites in each well were determined on days 2, 4 and 6 of the experiment. Results: Both percolated and Soxhlet extracts in methanol and DMSO solvents had significant effects (equal to that of amphotericin B) on promastigote form of parasite at the concentration of 1 mg/ml. At lower concentrations, the extracts of E. petiolata had favorable leishmanicidal activity and killed L. major promastigotes dose-dependently. Conclusion: Our results support the possibility of E. petiolata extracts application as an anti-leishmanial agent with similar effects to amphotericin B

Cessation or Continuation of Aspirin in Patients Undergoing 20-gauge Pars Plana Vitrectomy due to Diabetic Retinopathy

peer reviewe

A Model to Measure the Spread Power of Rumors

Nowadays, a significant portion of daily interacted posts in social media are infected by rumors. This study investigates the problem of rumor analysis in different areas from other researches. It tackles the unaddressed problem related to calculating the Spread Power of Rumor (SPR) for the first time and seeks to examine the spread power as the function of multi-contextual features. For this purpose, the theory of Allport and Postman will be adopted. In which it claims that there are two key factors determinant to the spread power of rumors, namely importance and ambiguity. The proposed Rumor Spread Power Measurement Model (RSPMM) computes SPR by utilizing a textual-based approach, which entails contextual features to compute the spread power of the rumors in two categories: False Rumor (FR) and True Rumor (TR). Totally 51 contextual features are introduced to measure SPR and their impact on classification are investigated, then 42 features in two categories "importance" (28 features) and "ambiguity" (14 features) are selected to compute SPR. The proposed RSPMM is verified on two labelled datasets, which are collected from Twitter and Telegram. The results show that (i) the proposed new features are effective and efficient to discriminate between FRs and TRs. (ii) the proposed RSPMM approach focused only on contextual features while existing techniques are based on Structure and Content features, but RSPMM achieves considerably outstanding results (F-measure=83%). (iii) The result of T-Test shows that SPR criteria can significantly distinguish between FR and TR, besides it can be useful as a new method to verify the trueness of rumors

Effect of Cytomegalovirus Exposure on the Atherosclerotic Events Among Kidney-Transplanted Patients, A Systematic Review and Meta-Analysis

peer reviewe

Automatic Personality Prediction; an Enhanced Method Using Ensemble Modeling

Human personality is significantly represented by those words which he/she uses in his/her speech or writing. As a consequence of spreading the information infrastructures (specifically the Internet and social media), human communications have reformed notably from face to face communication. Generally, Automatic Personality Prediction (or Perception) (APP) is the automated forecasting of the personality on different types of human generated/exchanged contents (like text, speech, image, video, etc.). The major objective of this study is to enhance the accuracy of APP from the text. To this end, we suggest five new APP methods including term frequency vector-based, ontology-based, enriched ontology-based, latent semantic analysis (LSA)-based, and deep learning-based (BiLSTM) methods. These methods as the base ones, contribute to each other to enhance the APP accuracy through ensemble modeling (stacking) based on a hierarchical attention network (HAN) as the meta-model. The results show that ensemble modeling enhances the accuracy of APP

Digital Diplomacy as a Tool for Empowering Governments: Formulating a Strategy for the Islamic Republic of Iran

Introduction                                   The information revolution has significantly altered the nature of power by enhancing the capacity of soft power and reshaping the very foundations of power structures. In the past, leaders and politicians were the primary figures to determine national interests in each nation, but in the digital age, the Internet and social networks have functioned to eliminate the mediatorship, leading to the highlighted role of the individual, the emergence of public opinions, and distribution of power from the government to people and other key actors. Today, power derived from public opinions is considered by political actors as a potent instrument for accomplishing political objectives.Iran’s Twenty-Year Vision Document, looking ahead to 2025, outlines a comprehensive objective of the Islamic Republic of Iran as to attain a preeminent economic and technological position in the region while preserving its Islamic and revolutionary identity, being a source of inspiration in the Islamic world, and engaging in a constructive interaction in international relations. To secure the top economic position in the region and an influential position in the international arena, it is imperative to leverage the capabilities of the country’s diplomatic apparatus. Diplomacy serves as the executive arm of foreign policy within the framework of a country’s foreign policy doctrine. To thrive in the evolving global landscape requires possessing modern tools since the shifting global landscape demands novel tools and approaches. In today’s world, powerful governments employ soft power instruments to influence and sway societies.Diplomacy stands as one of the most critical tools for advancing a country’s national power and achieving its objectives. Leading governments have embraced digital diplomacy as a means to bolster their national brand and effectively manage their public image, thus reaching vast audiences. In the contemporary age of communication, a formidable presence on the global stage necessitates the strategic implementation of digital diplomacy, positioning it at the forefront ofa country’s public diplomacy initiatives. In this respect, the present research aimed to recognize the role of digital diplomacy as a pivotalpower-building instrument, and to incorporate it into Iran’s strategic planning.This research intended to offer a full-brown description of digital diplomacy by delving into the power-building factors of modern media. The objective was to formulate effective strategies that enhance the digital diplomacy initiatives of the Islamic Republic of Iran, thereby strengthening Iran’s influential presence in global politics and increasing Iran’s soft power as an important dimension of power. The research tried to address the pivotal question concerning the role modern media can assume within a country’s diplomatic apparatus. This would involve understanding how media can contribute to advancing national interests and bolstering a country’s influence and authority in the international arena. This research also sought to propose key indicators and strategies for advancing Iran’s digital diplomacy initiatives.Literature ReviewNumerous case studies and comparative analyses have explored digital diplomacy, underscoring the significant impact of social media in international diplomacy. However, despite the close interconnection of technology, diplomacy, and soft power, there is a lack of research that systematically situates these three domains within a theoretical framework and examines international relations theories by considering the role of modern media on the power-building capacity of diplomacy.In the article titled “Shaping Public Diplomacy through Social Media Networks in the 21st Century,” Costa (2017) posits that the Internet and information and communication technology have significantly influenced the definition and performance of public diplomacy. In “Foreign Policy in an Era of Digital Diplomacy,”Adesina (2017) draws the conclusion that digital diplomacy and internet-based activities play a vital role in effectively communicating a government’s foreign policy stances to both domestic and international audiences.  In the article titled “Twitplomacy: Social Media as a New Platform for Development of Public Diplomacy,” Su (2015) argues that the impact of Internet users on the diplomatic agenda can complement political concepts. Considering the role of social media in the public diplomacy of the Islamic Republic of Iran, Ameli (2017) asserts that emerging social media technologies will play a central role in diplomacy by influencing social space.Ganjidoust (2008) focuses on the profound impact of information and communication technology in the field of diplomacy. The author contends that diplomacy has experienced greater influence from technological advancements compared to other domains, primarily because of its heavy reliance on the fundamental components of information and communication. According to Ganjidoust, the developments of the information age have brought about significant transformations in both the form and substance of diplomacy.Materials and MethodsThe Delphi technique was employed for identifying indicators, while the Dimetal technique was utilized for modeling. The study used Partial Least Squares technique to test the exploratory model and analyze the reciprocal influence between variables.ConclusionThe findings revealed that modern media plays a pivotal role as a complete mediator in the transfer of power to diplomacy. Through online communication, new media platforms foster interaction and networking among users. They employ activism, imagery, and psychological operations to craft their desired narrative, thus reinforce user engagement and convergence through orienting and streamlining, Ultimately, by fostering a sense of belonging, they establish identity and create opportunities within the system of diplomacy.To succeed in public diplomacy, particularly in the realm of digital diplomacy, requires a comprehensive strategy encompassing strategic goals, strategic priorities, and executive guidelines to attain the strategic goals. Concerning the Islamic Republic of Iran, the strategic goals are as follows: Making a powerful image of Iran, national branding of Iranian–Islamic identity, informing people about the policies, beliefs, and values of Iranians, and introducing opportunities and strengths. The strategic priorities of the digital diplomacy of the Islamic Republic of Iran include Interacting with citizens and foreign populations to foster and enhance mutual relations, providing transparent information and swift responses to counter misinformation, combating online hooliganism, presenting leadership guidelines, and engaging in social listening and social monitoring. Without a thorough analysis and practical solutions to this question, it is not possible to address the needs of audience satisfactorily. The assessment of attitudes, questions, and challenges is the most critical aspect which guides the subsequent actions. Concerning interaction, it is recommended to interact with influencers, as well as political, religious, cultural, and national figures, to clarify ambiguities and foster constructive dialogues through the dissemination of pre-prepared images, messages, and video clips. Moreover, regular evaluation of the outcomes on the basis of a theory of structures and processes can help ensure the effectiveness of digital diplomacy and coordination

Does resveratrol affect prepared sperm parameters and chromatin quality in normozoospermic and asthenozoospermic patients before and after freezing? A lab trial study

Background: Previous studies have examined the effect of resveratrol as a potent antioxidant for free radicals in semen. While, the prepared spermatozoa are more affected by ROS factors due to centrifugation and incubation. Objective: To evaluate the RSV’s effects on the prepared sperm parameters and chromatin quality in both normozoospermic and asthenozoospermic cases before and after freezing. Materials and Methods: The sample of 10 normozoospermic and asthenozoospermic men was prepared through the swim-up method. The groups were then divided into two samples of control and experimental (exposure to 30 μmol/l of RSV) to evaluate and compare the sperm parameters and chromatin quality before and after freezing. Results: The motility and viability of spermatozoa were seen to be significantly different before and after freezing separately in the control and treatment samples of the groups (p ≤ 0.001 and p = 0.001, respectively). However, the stated difference between the control and treatment samples of normozoospermic and asthenozoospermic patients were not significant (p &gt; 0.05). In addition, the sperm morphology and chromatin quality were not significantly different between the two samples of each group; nonetheless, chromatin quality of the treated sample was better than that of the control before and after freezing. Conclusion: Despite the protective effects of RSV on the semen samples, RSV cannot affect significantly the prepared sperms parameters and chromatin quality in normozoospermic and asthenozoospermic patients. Key words: Resveratrol, Chromatin, Motility, Spermatozoa, Freeze