Development and validation of RP-HPLC method for loxapine in capsule dosage form

A reversed phase-high performance liquid chromatography (RP-HPLC) method was developed for the determination of loxapine drug in tablet dosage form. The developed method was validated by measuring linearity, precision, limit of detection (LOD), robustness and ruggedness, drug recovery and for system suitability. Water and acetonitrile in the ratio 55:45 v/v was the mobile phase with C 18 column (250 mm x 4.5 mm x 5 m) as a stationary phase and 265 nm was the detection wavelength. The HPLC system was operated in isocratic mode. The measured retention time of loxapine drug was 6.88 minutes and the limit of detection was 0.035 g/ml, respectively. The linearity measured in the range 10-100 g/ml had a correlation coefficient of 0.999. The results of the parameters precision, robustness, recovery and formulation assay indicate that the developed method is a very good tool for the analysis of loxapine drug in tablet dosage form in bulk

Pharmacological studies of zinc oxide nanoparticles

500-505In this paper, we focused on the synthesis and characterization of zinc oxide nanoparticles by using a chemical method. The characterization of Zinc oxide Nanoparticles are determined by different spectroscopic techniques such as UV-Visible, DRS, FTIR, FESEM, and EDX. Further, the antimicrobial activity and cytotoxic studies also performed towards different bacterial species like Bacillus subtilis, Escherichia coli, fungi like Aspergillus niger and MCF-7 Breast Cancer cell line

Pharmacological studies of Zinc oxide Nanoparticles

In this paper, we focused on the synthesis and characterization of zinc oxide nanoparticles by using chemical method. The characterization of Zinc oxide Nanoparticles are determined by different spectroscopic techniques such as UV-VISIBLE, DRS, FT-IR, FE­SEM, and EDX. Further the antimicrobial activity and cytotoxic studies also performed towards different bacterial species like Bacillus subtilis, Escherichi coli, fungi like Aspergillus niger and MCF-7 Breast Cancer cell line

Pharmacological studies of zinc oxide nanoparticles

In this paper, we focused on the synthesis and characterization of zinc oxide nanoparticles by using a chemical method. The characterization of Zinc oxide Nanoparticles are determined by different spectroscopic techniques such as UV-Visible, DRS, FTIR, FESEM, and EDX. Further, the antimicrobial activity and cytotoxic studies also performed towards different bacterial species like Bacillus subtilis, Escherichia coli, fungi like Aspergillus niger and MCF-7 Breast Cancer cell line

Copper promoted synthesis of tetrazoles and further conversion into diaryl tetrazoles through C-N cross-coupling approach

313-324Efficient tandem three component method has been demonstrated for the synthesis of substituted tetrazoles under mild reaction conditions using copper catalysis. Green solvent DMSO has been utilized and the reaction has been carried out at room temperature which establishes that our method is green synthetic approach. Variety of substrates readily undergo the optimized reaction conditions to provide their respective target products in good to excellent yields. In addition we have observed regioselective compounds depending on the substituents of phenyl ring. All the reactions are rapid, facile and are accomplished at room temperature. The reactions are of general application, clean and efficient. Furthermore we have confirmed that no other by-products could be identified during our experimental reaction process. In addition, C-N cross-coupling have been developed with phenyltetrazoleamines and aryl iodide under moderate reaction conditions

Copper promoted synthesis of tetrazoles and further conversion into diaryl tetrazoles through C-N cross-coupling approach

Efficient tandem three component method has been demonstrated for the synthesis of substituted tetrazoles under mild reaction conditions using copper catalysis. Green solvent DMSO has been utilized and the reaction has been carried out at room temperature which establishes that our method is green synthetic approach. Variety of substrates readily undergo the optimized reaction conditions to provide their respective target products in good to excellent yields. In addition we have observed regioselective compounds depending on the substituents of phenyl ring. All the reactions are rapid, facile and are accomplished at room temperature. The reactions are of general application, clean and efficient. Furthermore we have confirmed that no other by-products could be identified during our experimental reaction process. In addition, C-N cross-coupling have been developed with phenyltetrazoleamines and aryl iodide under moderate reaction conditions

One-pot three-component tandem reaction: Synthesis of aryl/alkyl cyanamides libraries and their further conversion into tetrazole derivatives

<p>We have developed methodology for the synthesis of aryl/alkyl cyanamides from amines in one-pot four steps reaction using cheap, readily available and air stable copper source as catalyst under mild reaction conditions. We have also studied the application of cyanamides. In this connection, we could construct aryl tetrazolamine from cyanamides using click reaction</p