CLINICO-CYTOLOGICAL AND HISTOPATHOLOGICAL CORRELATION OF LYMPHADENOPATHY IN PEDIATRIC PATIENTS

Objective: The aim of the present study was to evaluate the cytomorphological and histopathological (wherever possible) patterns of lymph node (LN) lesions along with clinical correlation in the pediatric population. Methods: This was a prospective study conducted on 100 pediatric patients (aged <12 years) who presented with lymphadenopathy (LAP). Fine-needle aspiration cytology (FNAC) was performed on all cases out of which only 22 underwent surgical excision and histopathological examination. Aspirated material was stained with May-Grunwald Giemsa, Papanicolaou, Z-N stain (wherever required) and for histopathology, Hematoxylin and eosin stain was used. Results: Majority number of patients was in the age group of 5–8 years (44%). Cervical LN s were most commonly involved (71%). Out of the total 100 cases, 91% were benign, 3% were malignant and 6% were inadequate. Most common cytologically diagnosed entity was non-specific reactive lymphadenitis (68%). There was one case of reactive lymphadenitis on cytology that proved to be Hodgkin lymphoma on histopathology. Two cases of generalized LAP given as atypical lymphoproliferative lesion on cytopathology proved to be acute lymphoblastic leukemia/lymphoma on further investigation. The cytomorphological findings were found to be concordant with histopathology in 21 cases out of 22 with a diagnostic accuracy rate of 95.45%. Conclusion: FNAC is especially helpful as LN biopsy is a difficult and invasive procedure in children. Although excision biopsy is the gold standard, FNAC is preferred as first-line investigation. Along with cell block analysis and ancillary techniques, it provides an excellent diagnostic accuracy

ASCARIASIS AS A CAUSE OF ACALCULUS EOSINOPHILIC CHOLECYSTITIS - A RARE CASE REPORT

Acalculus eosinophilic cholecystitis is a variant of chronic cholecystitis which is an inflammation of gall bladder. Here we presents a case of female child of 10 years age with features of abdominal pain for 6 months which after investigations found to be of an eosinophilic cholecystitis cuased by Ascaris lumricoides- a rare entity

ASCARIASIS AS A CAUSE OF ACALCULUS EOSINOPHILIC CHOLECYSTITIS - A RARE CASE REPORT

Acalculus eosinophilic cholecystitis is a variant of chronic cholecystitis which is an inflammation of gall bladder. Here we presents a case of female child of 10 years age with features of abdominal pain for 6 months which after investigations found to be of an eosinophilic cholecystitis cuased by Ascaris lumricoides- a rare entity

ASCARIASIS AS A CAUSE OF ACALCULUS EOSINOPHILIC CHOLECYSTITIS - A RARE CASE REPORT

Acalculus eosinophilic cholecystitis is a variant of chronic cholecystitis which is an inflammation of gall bladder. Here we presents a case of female child of 10 years age with features of abdominal pain for 6 months which after investigations found to be of an eosinophilic cholecystitis cuased by Ascaris lumricoides- a rare entit

EOSINOPHILIC GASTRITIS- A RARE CAUSE OF GASTRIC WALL THICKNESS: A RARE CASE REPORT

Idiopathic eosinophilic gastroenteritis is a rare inflammatory disease of unknown origin, characterized by diffuse eosinophilic infiltration of the gastrointestinal tract, accompanied by varying abdominal symptoms related to the location, severity and depth of invasion. A 63-year old male was admitted to our hospital with complaints of abdominal pain and constipation. Physical examination revealed a distended abdomen with diffuse tenderness. Ultrasound showed free fluid in peritoneal cavity. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Pylorus of stomach showed thickening of wall. A Gastric perforation with indurated and rolled margins was identified, gastrojejunostomy was performed and provisional diagnosis of malignant growth with complication of perforation was made but histologically, thickened wall of the stomach revealed dense infiltration of eosinophils and eosiniphilic gastroenteritis was diagnosed. KEYWORDS: Eosinophils, Gastroenteritis; Eosinophilic gastroenteritis; Coticosteroid

CYTOLOGICAL, HPV GENOME, AND HISTOPATHOLOGICAL CORRELATION OF CERVICAL SMEARS IN FEMALES 30 YEARS AND ABOVE

Objectives: The objectives of the study were to evaluate the patterns of cervical smear cytology in relation to human papillomavirus (HPV) and to correlate with histopathological diagnosis in females of 30 years and above. Methods: The 2-year prospective study was done in the Department of Pathology in 100 patients who attended the Gynaecology OPD of Govt. Medical College, Patiala. The cervical brushings obtained were subjected to cytological examination by liquid-based cytology through SurePath method and for HPV evaluation by BD Onclarity HPV assay. The cytological findings were further correlated with histopathological examination. Results: Majority of the females were in the age group of 30−45 years (62%). There was high incidence of dysplasia and malignancy in those who were of parity 3, 4, and above. The most common presenting symptom was discharge per vaginum (DPV) seen in 28% of cases. Maximum cases on cytology were diagnosed as NILM (including inflammatory pathology, 49%) followed by LSIL as 14% and malignant as 13%. Overall HPV genome was detected in 54% of the samples, the cases diagnosed as dysplasia and malignancy showed 68.42% and 100% presence of HPV, respectively. This was found to be statistically significant (p<0.05). Conclusion: Pap smear along with HPV evaluation is an effective screening method for the detection of pre-invasive lesions and cancers of cervix that are potentially curable

EOSINOPHILIC GASTRITIS- A RARE CAUSE OF GASTRIC WALL THICKNESS: A RARE CASE REPORT

Idiopathic eosinophilic gastroenteritis is a rare inflammatory disease of unknown origin, characterized by diffuse eosinophilic infiltration of the gastrointestinal tract, accompanied by varying abdominal symptoms related to the location, severity and depth of invasion. A 63-year old male was admitted to our hospital with complaints of abdominal pain and constipation. Physical examination revealed a distended abdomen with diffuse tenderness. Ultrasound showed free fluid in peritoneal cavity. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Pylorus of stomach showed thickening of wall. A Gastric perforation with indurated and rolled margins was identified, gastrojejunostomy was performed and provisional diagnosis of malignant growth with complication of perforation was made but histologically, thickened wall of the stomach revealed dense infiltration of eosinophils and eosiniphilic gastroenteritis was diagnosed. KEYWORDS: Eosinophils, Gastroenteritis; Eosinophilic gastroenteritis; Coticosteroid

Original Article Section: Pathology Histopathological Pattern of Soft Tissue Tumours in 200 Cases

were the second commonest (18%) followed by peripheral nerve sheath tumors (10.5%). The benign tumors were seen in younger age as compared to malignant tumors. Conclusion: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma (14.0%) and schwannoma (5.5%).There is wide range of their distribution according to age, sex and site. The benign tumors were seen in younger age as compared to malignant tumors