Gadolinium Toxicity and Treatment

Gadolinium based contrast agents (GBCAs) play an important role in the diagnostic evaluation of many patients. The safety of these agents has been once again questioned after gadolinium deposits were observed and measured in brain and bone of patients with normal renal function. This retention of gadolinium in the human body has been termed "gadolinium storage condition". The long-term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. Recently, patients who report that they suffer from chronic symptoms secondary to gadolinium exposure and retention created gadolinium-toxicity on-line support groups. Their self-reported symptoms have recently been published. Bone and joint complaints, and skin changes were two of the most common complaints. This condition has been termed "gadolinium deposition disease". In this review we will address gadolinium toxicity disorders, from acute adverse reactions to GBCAs to gadolinium deposition disease, with special emphasis on the latter, as it is the most recently described and least known.info:eu-repo/semantics/publishedVersio

Aptidão agrícola das terras do Brasil: potencial de terras e análise dos principais métodos de avaliação.

O conhecimento da aptidão de terras e fator de grande importância para propiciar o uso adequado da oferta ambiental e, sobretudo, evitar possível sobreutilização dos recursos naturais. Fundamentalmente, este estudo foi realizado com o objetivo de oferecer uma visão sinóptica sobre o potencial agrícola e disponibilidade das terras do Brasil, bem como apresentar uma analise critica sobre os principais métodos e sistemas de avaliação da aptidão das terras. Este documento e o resultado da consolidação dos estudos básicos para o planejamento agrícola das terras de cada Estado da Federação, realizadas pelo Ministério da Agricultura, através da Secretaria Nacional de Planejamento - SUPLAN - entre 1977 e 1980. Não obstante o nível generalizado dos dados utilizados, foram interpretados os mais atualizados levantamentos de solos realizados no pais. O estudo fornece subsidio para projetar e dimensionar a oferta potencial de terras para atender a uma demanda, também projetada, de produtos agrícolas. O método utilizado foi o "sistema de avaliação da aptidão agrícola das terras", preconizado pela EMBRAPA Solos, no qual são adotados três níveis de manejo (níveis de tecnologia), visando diagnosticar o comportamento das terras em níveis operacionais distintos.bitstream/item/36134/1/Aptidao-agricula.pd

A parameter for quantitative analysis of plasticity induced crack closure

Numerical models have been successfully developed to predict plasticity induced crack closure (PICC). However, despite the large research effort a full understanding of the links between physical parameters, residual plastic wake and PICC has not been achieved yet. The plastic extension of material behind crack tip, Δyp, obtained by the integration of vertical plastic deformation perpendicularly to crack flank, is proposed here to quantify the residual plastic field. The values of Δyp and PICC were obtained numerically in a M(T) specimen using the finite element method. An excellent correlation was found between PICC and Δyp which indicates that this parameter controls the phenomenon, and can be used to quantify the effect of physical parameters. An empirical model was developed to predict PICC assuming that the residual plastic field is a set of vertical plastic wedges, that the linear superposition principle applies and that the influence of a particular wedge exponentially decreases with distance to crack tip. The model was applied successfully to predict PICC for different residual plastic fields which provided an additional validation of Δyp as the parameter controlling PICC

Plasticity induced crack closure: a sensitivity analysis

Plasticity induced crack closure (PICC) is closely linked to the monotonic and reversed plastic deformation occurring at the crack tip. The objective of the paper is to identify the different physical and numerical parameters affecting PICC, and develop a sensitivity analysis to quantify their relative importance. The main parameters affecting PICC are the load parameters, the yield stress, the size of finite elements and the numerical parameter considered to quantify PICC. The numerical predictions should be independent of numerical parameters, therefore further work is required to optimize the numerical modelsFCT e FEDE

A parameter for quantitative analysis of plasticity induced crack closure

Numerical models have been successfully developed to predict plasticity induced crack closure (PICC). However, despite the large research effort a full understanding of the links between physical parameters, residual plastic wake and PICC has not been achieved yet. The plastic extension of material behind crack tip, Dyp, obtained by the integration of vertical plastic deformation perpendicularly to crack flank, is proposed here to quantify the residual plastic field. The values of Dyp and PICC were obtained numerically in a M(T) specimen using the finite element method. An excellent correlation was found between PICC and Dyp which indicates that this parameter controls the phenomenon, and can be used to quantify the effect of physical parameters. An empirical model was developed to predict PICC assuming that the residual plastic field is a set of vertical plastic wedges, that the linear superposition principle applies and that the influence of a particular wedge exponentially decreases with distance to crack tip. The model was applied successfully to predict PICC for different residual plastic fields which provided an additional validation of Dyp as the parameter controlling PICC.info:eu-repo/semantics/publishedVersio

Hand-based multimodal identification system with secure biometric template storage

WOS:000304107200001This study proposes a biometric system for personal identification based on three biometric characteristics from the hand, namely: the palmprint, finger surfaces and hand geometry. A protection scheme is applied to the biometric template data to guarantee its revocability, security and diversity among different biometric systems. An error-correcting code (ECC), a cryptographic hash function (CHF) and a binarisation module are the core of the template protection scheme. Since the ECC and CHF operate on binary data, an additional feature binarisation step is required. This study proposes: (i) a novel identification architecture that uses hand geometry as a soft biometric to accelerate the identification process and ensure the system's scalability; and (ii) a new feature binarisation technique that guarantees that the Hamming distance between transformed binary features is proportional to the difference between their real values. The proposed system achieves promising recognition and speed performances on two publicly available hand image databases.info:eu-repo/semantics/acceptedVersio

Simulation of crack growth in residual stress fields of pre-fatigued T-welded joints repaired by tungsten inert gas: a 3D approach

In this article, a three-dimensional finite element model (FEM) is used to predict the crack growth at the weld toe of a pre-fatigued T-joint that was repaired with a remelting technique. The numerical models were developed using the MSC.Marc software. Fatigue life is estimated by integrating the Paris-Erdogan law. The stress intensity factors are obtained by the virtual crack closure technique (VCCT). The T-welded joints, made of S355 steel, are obtained by covered electrode process and pre-cracked by fatigue. These welded joints were repaired by TIG dressing. The stress field generated by this dressing technique was estimated using a FEM model, presented in authors’ previous works. For the crack growth was used the VCCT three-dimensional model recently presented by the authors to predict the effect of overloads. The pre-existence of an elliptical crack at the weld toe, with a depth of 0.5 mm was considered. It is also studied the growth of pre-existing cracks which have been poorly repaired. It was observed that the TIG dressing produce residual compression stress fields on the weld toe that causes a delay in crack growth. The obtained results are compared with experimental ones. The fatigue’s lives obtained by simulations with the numerical model presented in this paper allows to evaluate the application conditions of TIG remelting technique in the repair of pre-cracked welded joints.info:eu-repo/semantics/publishedVersio

Structure and Phase Transformations of DPPC Lipid Bilayers in the Presence of Nanoparticles: Insights from Coarse-Grained Molecular Dynamics Simulations

In this article, we investigate fluid-gel transformations of a DPPC lipid bilayer in the presence of nanoparticles, using coarse grained molecular dynamics. Two types of nanoparticles are considered, specifically a 3 nm hydrophobic nanoparticle located in the core of the bilayer and a 6 nm charged nanoparticle located at the interface between the bilayer and water phase. Both negatively and positively charged nanoparticles at the bilayer interface are investigated. We demonstrate that the presence of all types of nanoparticles induces disorder effects in the structure of the lipid bilayer. These effects are characterized using computer visualization of the gel phase in the presence of nanoparticles, radial distribution functions, and order parameters. The 3 nm hydrophobic nanoparticle immersed in the bilayer core and the positively charged nanoparticle at the bilayer surface have no effect on the temperature of the fluid-gel transformation, compared to the bulk case. Interestingly, a negatively charged hydrophobic nanoparticle located at the surface of the bilayer causes slight shift of the fluid-gel transformation to a lower temperature, compared to the bulk bilayer case

Mechanical and tribological characterization of four commercial braking formulation materials

Organic friction materials for brake linings, namely brake pads are polymer matrix composites usually containing numerous macroscopic as well as microscopic constituents such as filamentary reinforcements, solid lubricants, abrasives and fillers. Their main objective of the these composite system are that a constant and stable coefficient of friction (COF) is provided irrespective of environmental conditions such as pressure, sliding velocity, temperature, humidity etc. Brake pads performance should be maintained over a wide range of stress conditions. Although the wear of the brake pad is inevitable, it should be minimized as far as possible. While cast iron has been the dominant material for brake discs, brake pad materials are constantly evolving into more complex composites. The main objectives of the present work is to characterize the physical and the tribological behavior of four commercial braking pads material formulations. For all compositions the studied factors are normal pressure and sliding speed, considering one braking-test protocol designed with temperature and friction load data acquisition. A double pad-on-disc tribological test configuration was used to determine tribological properties of brake pad for heavy vehicles commercial. Three wear tests via increased severity of rubbing conditions for a constant braking distance.The authors acknowledge Auto Travões Viseu-recondicionamento de Travões e embraiagens Lda the support through the provision of the frictrion linning materials presented in the study