101 research outputs found
Prospective longitudinal evaluation of treatment-related toxicity and health-related quality of life during the first year of treatment for pediatric acute lymphoblastic leukemia
Background Pediatric acute lymphoblastic leukemia (ALL) therapy is accompanied by treatment-related toxicities (TRTs) and impaired quality of life. In Australia and New Zealand, children with ALL are treated with either Children's Oncology Group (COG) or international Berlin-Frankfurt-Munster (iBFM) Study Group-based therapy. We conducted a prospective registry study to document symptomatic TRTs (venous thrombosis, neurotoxicity, pancreatitis and bone toxicity), compare TRT outcomes to retrospective TRT data, and measure the impact of TRTs on children's general and cancer-related health-related quality of life (HRQoL) and parents' emotional well-being. Methods Parents of children with newly diagnosed ALL were invited to participate in the ASSET (Acute Lymphoblastic Leukaemia Subtypes and Side Effects from Treatment) study and a prospective, longitudinal HRQoL study. TRTs were reported prospectively and families completed questionnaires for general (Healthy Utility Index Mark 3) and cancer specific (Pediatric Quality of Life Inventory (PedsQL)-Cancer Module) health related quality of life as well the Emotion Thermometer to assess emotional well-being. Results Beginning in 2016, 260 pediatric patients with ALL were enrolled on the TRT registry with a median age at diagnosis of 59âmonths (range 1-213âmonths), 144 males (55.4%), majority with Pre-B cell immunophenotype, nâ=â226 (86.9%), 173 patients (66.5%) treated according to COG platform with relatively equal distribution across risk classification sub-groups. From 2018, 79 families participated in the HRQoL study through the first year of treatment. There were 74 TRT recorded, reflecting a 28.5% risk of developing a TRT. Individual TRT incidence was consistent with previous studies, being 7.7% for symptomatic VTE, 11.9% neurotoxicity, 5.4% bone toxicity and 5.0% pancreatitis. Children's HRQoL was significantly lower than population norms throughout the first year of treatment. An improvement in general HRQoL, measured by the HUI3, contrasted with the lack of improvement in cancer-related HRQoL measured by the PedsQL Cancer Module over the first 12âmonths. There were no persisting differences in the HRQoL impact of COG compared to iBFM therapy. Conclusions It is feasible to prospectively monitor TRT incidence and longitudinal HRQoL impacts during ALL therapy. Early phases of ALL therapy, regardless of treatment platform, result in prolonged reductions in cancer-related HRQoL.Clarissa E. Schilstra, Karen McCleary, Joanna E. Fardell, Mark W. Donoghoe, Emma McCormack, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla, Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Marion K. Mateos, and Toby N. Trahai
Effect of event selection on jetlike correlation measurement in d+Au collisions at sNN=200Â GeV
AbstractDihadron correlations are analyzed in sNN=200Â GeV d+Au collisions classified by forward charged particle multiplicity and zero-degree neutral energy in the Au-beam direction. It is found that the jetlike correlated yield increases with the event multiplicity. After taking into account this dependence, the non-jet contribution on the away side is minimal, leaving little room for a back-to-back ridge in these collisions
J/Ï polarization in p+p collisions at s=200 GeV in STAR
AbstractWe report on a polarization measurement of inclusive J/Ï mesons in the di-electron decay channel at mid-rapidity at 2<pT<6 GeV/c in p+p collisions at s=200 GeV. Data were taken with the STAR detector at RHIC. The J/Ï polarization measurement should help to distinguish between different models of the J/Ï production mechanism since they predict different pT dependences of the J/Ï polarization. In this analysis, J/Ï polarization is studied in the helicity frame. The polarization parameter λΞ measured at RHIC becomes smaller towards high pT, indicating more longitudinal J/Ï polarization as pT increases. The result is compared with predictions of presently available models
Beam-energy Dependence Of Charge Balance Functions From Au + Au Collisions At Energies Available At The Bnl Relativistic Heavy Ion Collider
Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)Balance functions have been measured in terms of relative pseudorapidity (Îη) for charged particle pairs at the BNL Relativistic Heavy Ion Collider from Au + Au collisions at sNN=7.7GeV to 200 GeV using the STAR detector. These results are compared with balance functions measured at the CERN Large Hadron Collider from Pb + Pb collisions at sNN=2.76TeV by the ALICE Collaboration. The width of the balance function decreases as the collisions become more central and as the beam energy is increased. In contrast, the widths of the balance functions calculated using shuffled events show little dependence on centrality or beam energy and are larger than the observed widths. Balance function widths calculated using events generated by UrQMD are wider than the measured widths in central collisions and show little centrality dependence. The measured widths of the balance functions in central collisions are consistent with the delayed hadronization of a deconfined quark gluon plasma (QGP). The narrowing of the balance function in central collisions at sNN=7.7 GeV implies that a QGP is still being created at this relatively low energy. © 2016 American Physical Society.942CNPq, Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgicoMinistry of Education and Science of the Russian FederationMOE, Ministry of Education of the People's Republic of ChinaMOST, Ministry of Science and Technology of the People's Republic of ChinaNRF-2012004024, National Research FoundationNSF, National Stroke FoundationConselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq
Prediction of adsorption equilibria of waterâmethanol mixtures in zeolite NaA by molecular simulation
J/Ï Production At Low Pt In Au+au And Cu+cu Collisions At Snn =200 Gev With The Star Detector
The J/Ï pT spectrum and nuclear modification factor (RAA) are reported for pT<5GeV/c and |y|<1 from 0% to 60% central Au+Au and Cu+Cu collisions at sNN=200GeV at STAR. A significant suppression of pT-integrated J/Ï production is observed in central Au+Au events. The Cu+Cu data are consistent with no suppression, although the precision is limited by the available statistics. RAA in Au+Au collisions exhibits a strong suppression at low transverse momentum and gradually increases with pT. The data are compared to high-pT STAR results and previously published BNL Relativistic Heavy Ion Collider results. 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Dielectron Azimuthal Anisotropy At Mid-rapidity In Au+au Collisions At Snn =200 Gev
We report on the first measurement of the azimuthal anisotropy (v2) of dielectrons (e+e- pairs) at mid-rapidity from sNN=200 GeV Au+Au collisions with the STAR detector at the Relativistic Heavy Ion Collider (RHIC), presented as a function of transverse momentum (pT) for different invariant-mass regions. In the mass region Mee<1.1 GeV/c2 the dielectron v2 measurements are found to be consistent with expectations from Ï0,η,Ï, and Ï decay contributions. In the mass region 1.1<Mee<2.9GeV/c2, the measured dielectron v2 is consistent, within experimental uncertainties, with that from the ccÂŻ contributions.906Adams, J., (2005) Nucl. Phys. A, 757, p. 102. , NUPABL 0375-9474Arsene, I., (2005) Nucl. Phys. A, 757, p. 1. , NUPABL 0375-9474Adcox, K., (2005) Nucl. Phys. A, 757, p. 184. , NUPABL 0375-9474Back, B.B., (2005) Nucl. Phys. A, 757, p. 28. , NUPABL 0375-9474Rapp, R., Wambach, J., (2002) Adv. Nucl. Phys., 25, p. 1. , 0065-2970David, G., Rapp, R., Xu, Z., (2008) Phys. 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Beam-energy Dependence Of Charge Separation Along The Magnetic Field In Au+au Collisions At Rhic
Local parity-odd domains are theorized to form inside a quark-gluon plasma which has been produced in high-energy heavy-ion collisions. The local parity-odd domains manifest themselves as charge separation along the magnetic field axis via the chiral magnetic effect. The experimental observation of charge separation has previously been reported for heavy-ion collisions at the top RHIC energies. In this Letter, we present the results of the beam-energy dependence of the charge correlations in Au+Au collisions at midrapidity for center-of-mass energies of 7.7, 11.5, 19.6, 27, 39, and 62.4 GeV from the STAR experiment. After background subtraction, the signal gradually reduces with decreased beam energy and tends to vanish by 7.7 GeV. This implies the dominance of hadronic interactions over partonic ones at lower collision energies. © 2014 American Physical Society.1135DOE; National Research Foundation; CNRS/IN2P3; NSF; National Research Foundation; NRF-2012004024; National Research FoundationVafa, C., Witten, E., (1984) Phys. Rev. Lett., 53, p. 535. , PRLTAO 0031-9007 10.1103/PhysRevLett.53.535Lee, D.T., (1973) Phys. Rev. D, 8, p. 1226. , PRVDAQ 0556-2821 10.1103/PhysRevD.8.1226Lee, T.D., Wick, G.C., (1974) Phys. Rev. D, 9, p. 2291. , PRVDAQ 0556-2821 10.1103/PhysRevD.9.2291Kharzeev, D.E., McLerran, L.D., Warringa, H.J., (2008) Nucl. Phys., A803, p. 227. , NUPBBO 0375-9474 10.1016/j.nuclphysa.2008.02.298Kharzeev, D., (2006) Phys. Lett. B, 633, p. 260. , PYLBAJ 0370-2693 10.1016/j.physletb.2005.11.075Kharzeev, D., Zhitnitsky, A., (2007) Nucl. Phys., A797, p. 67. , NUPBBO 0375-9474 10.1016/j.nuclphysa.2007.10.001Fukushima, K., Kharzeev, D.E., Warringa, H.J., (2008) Phys. Rev. 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Fluctuations Of Charge Separation Perpendicular To The Event Plane And Local Parity Violation In S Nn = 200 Gev Au + Au Collisions At The Bnl Relativistic Heavy Ion Collider
Previous experimental results based on data (âŒ15Ă106 events) collected by the STAR detector at the BNL Relativistic Heavy Ion Collider suggest event-by-event charge-separation fluctuations perpendicular to the event plane in noncentral heavy-ion collisions. Here we present the correlator previously used split into its two component parts to reveal correlations parallel and perpendicular to the event plane. The results are from a high-statistics 200-GeV Au + Au collisions data set (57Ă106 events) collected by the STAR experiment. We explicitly count units of charge separation from which we find clear evidence for more charge-separation fluctuations perpendicular than parallel to the event plane. We also employ a modified correlator to study the possible P-even background in same- and opposite-charge correlations, and find that the P-even background may largely be explained by momentum conservation and collective motion. © 2013 American Physical Society.886NRF-2012004024; National Research FoundationLee, T.D., Yang, C.N., (1956) Phys. Rev., 104. , 1, 254. 0031-899X PHRVAO 10.1103/PhysRev.104.254Vafa, C., Witten, E., (1984) Phys. Rev. Lett., 53. , 2, 535. 0031-9007 PRLTAO 10.1103/PhysRevLett.53.535Lee, T.D., (1973) Phys. Rev. D, 8. , 3, 1226. 0556-2821 10.1103/PhysRevD.8.1226Lee, T.D., Wick, G.C., (1974) Phys. Rev. D, 9. , 4, 2291. 0556-2821 10.1103/PhysRevD.9.2291Kharzeev, D., Parity violation in hot QCD: Why it can happen, and how to look for it (2006) Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics, 633 (2-3), pp. 260-264. , DOI 10.1016/j.physletb.2005.11.075, PII S0370269305017430Kharzeev, D., Zhitnitsky, A., (2007) Nucl. Phys. A, 797. , 6, 67. 0375-9474 NUPABL 10.1016/j.nuclphysa.2007.10.001Kharzeev, D., McLerran, L.D., Warringa, H.J., (2008) Nucl. Phys. A, 803. , 7, 227. 0375-9474 NUPABL 10.1016/j.nuclphysa.2008.02.298Fukushima, K., Kharzeev, D.E., Warringa, H.J., (2008) Phys. Rev. D, 78. , 8, 074033. 1550-7998 PRVDAQ 10.1103/PhysRevD.78.074033Abelev, B.I., (2009) Phys. Rev. Lett., 103. , 9 (STAR Collaboration), 251601. 0031-9007 PRLTAO 10.1103/PhysRevLett.103. 251601Abelev, B.I., (2010) Phys. Rev. C, 81. , 10 (STAR Collaboration), 054908. 0556-2813 PRVCAN 10.1103/PhysRevC.81. 054908Abelev, B.I., (2013) Phys. Rev. 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International nosocomial infection control consortium (INICC) report, data summary of 36 countries, for 2004-2009
The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia). Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved
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