Mock-Gaussian Behaviour for Linear Statistics of Classical Compact Groups

We consider the scaling limit of linear statistics for eigenphases of a matrix taken from one of the classical compact groups. We compute their moments and find that the first few moments are Gaussian, whereas the limiting distribution is not. The precise number of Gaussian moments depends upon the particular statistic considered

Study of factors which modify the development of norepinephrine-induced acute renal failure in the dog

Study of factors which modify the development of norepinephrine-induced acute renal failure in the dog. Previous studies have demonstrated that the fall in inulin clearance which occurs 3 hours after the intrarenal administration of norepinephrine can be markedly attenuated by the prior administration of intrarenal prostaglandin E2 (PGE). Since in the previous studies PGE led to a marked increase in both renal blood flow and solute excretion, we designed the present series of experiments to investigate whether an increase in renal blood flow, solute excretion, or other factors were responsible for the protective effect in the norepinephrine model. Two renal vasodilators, bradykinin and secretin, were evaluated initially. Bradykinin administration prior to norepinephrine administration had a protective effect similar to that previously found with PGE, whereas secretin did not. Both of these vasodilators increased renal blood flow to the same degree, but only bradykinin increased urine flow and solute excretion. The fall in inulin clearance 3 hours after the administration of norepinephrine was also attenuated by two diuretics (mannitol and furosemide) which tended to increase renal blood flow. In contrast, two natriuretic agents, which are also renal vasoconstrictors (chlorothiazide and benzolamide), had no protective effect. Further, chlorothiazide and benzolamide obvicited the protective effect of bradykinin. These studies demonstrate that there are several types of pharmacologic agents which can modify the magnitude of renal functional impairment resulting from extreme renal ischemia. Although the mechanism of the protective effects remain unclear, the findings are compatible with the view that the protective effect noted with PGE, bradykinin, mannitol, and furosemide may be related to an increase in osmolar excretion which occurred with administration of each of these agents. This potentially salutory effect (increased osmolar excretion), however, could be overcome by an agent (e.g., chlorothictzide or benzolamide) which also increased renal resistance prior to the administration of norepinephrine.Etude des facteurs qui modifient l'évolution de l'insuffisance rénale aiguë par la norépinéphrine chez le chien. Des travaux antérieurs ont démontré que la chute de la clearance de l'inuline qui survient 3 heures après l'administration intra-rénale de norépinéphrine peut être atténuée de façon importante par l'injection intrarénale préalable de prostaglandine E2 (PGE). Puisque dans les travaux antérieurs, la PGE a déterminé une augmentation importante à la fois du débit sanguin rénal et de l'excrétion de substances dissoutes, cette série d'expériences a pour but de savoir si une augmentation du débit sanguin rénal ou de l'excrétion de substances dissoutes ou bien d'autres facteurs sont responsables de l'effet protecteur dans le modèle de la norépinéphrine. Deux vasodilatateurs rénaux, la bradykinine et la secrétine ont été initialement étudiés. L'administration de bradykinine préalable à celle de norépinéphrine a un effet protecteur semblable à celui antérieurement observé avec la PGE alors que la secrétine n'a pas cet effet. Ces deux vasodilatateurs augmentent le débit sanguin rénal de la même façon, mais seule la bradykinine augmente le débit urinaire et l'excrétion de substances dissoutes. La chute de la clearance de l'inuline 3 heures après la norépinéphrine est aussi atténuée par deux diurétiques qui tendent à augmenter le débit sanguin rénal (mannitol et furosémide). Au contraire, deux agents natriurétiques qui sont aussi des vasoconstricteurs rénaux (chlorothiazide et benzolamide) n'ont pas d'effet protecteur. De plus, ces deux corps empêchent l'effet protecteur de la bradykinine. Ces études démontrent qu'il y a plusieurs catégories d'agents pharmacologiques qui peuvent modifier l'importance de l'altération fonctionnelle qui résulte d'une ischémie rénale extrême. Quoique le mécanisme de l'effet protecteur reste obscur, ces constatations sont compatibles avec l'idée que l'effet observé avec la PGE, la bradykinine, le mannitol et le furosémide puisse être lié à une augmentation de l'excrétion osmolaire qui est observée au cours de l'administration de chacun de ces corps. Cet effet bénéfique potentiel (l'augmentation de l'excrétion osmolaire) peut, cependant, être annulé par un agent (comme le chlorothiazide ou la benzolamide) qui augmente aussi la résistance rénale préalablement à l'administration de norépinéphrine

Climatic suitability of the eastern paralysis tick, Ixodes holocyclus, and its likely geographic distribution in the year 2050

The eastern paralysis tick, Ixodes holocyclus is one of two ticks that cause potentially fatal tick paralysis in Australia, and yet information on the full extent of its present or potential future spatial distribution is not known. Occurrence data for this tick species collected over the past two decades, and gridded environmental variables at 1 km2 resolution representing climate conditions, were used to derive correlative ecological niche models to predict the current and future potential distribution. Several hundreds of candidate models were constructed with varying combinations of model parameters, and the best-fitting model was chosen based on statistical significance, omission rate, and Akaike Information Criterion (AICc). The best-fitting model matches the currently known distribution but also extends through most of the coastal areas in the south, and up to the Kimbolton peninsula in Western Australia in the north. Highly suitable areas are present around south of Perth, extending towards Albany, Western Australia. Most areas in Tasmania, where the species is not currently present, are also highly suitable. Future spatial distribution of this tick in the year 2050 indicates moderate increase in climatic suitability from the present-day prediction but noticeably also moderate to low loss of climatically suitable areas elsewhere

Molecular mode-coupling theory applied to a liquid of diatomic molecules

We study the molecular mode coupling theory for a liquid of diatomic molecules. The equations for the critical tensorial nonergodicity parameters ${\bf F}_{ll'}^m(q)$ and the critical amplitudes of the $\beta$ - relaxation ${\bf H}_{ll'}^m(q)$ are solved up to a cut off $l_{co}$ = 2 without any further approximations. Here $l,m$ are indices of spherical harmonics. Contrary to previous studies, where additional approximations were applied, we find in agreement with simulations, that all molecular degrees of freedom vitrify at a single temperature $T_c$. The theoretical results for the non ergodicity parameters and the critical amplitudes are compared with those from simulations. The qualitative agreement is good for all molecular degrees of freedom. To study the influence of the cut off on the non ergodicity parameter, we also calculate the non ergodicity parameters for an upper cut off $l_{co}=4$. In addition we also propose a new method for the calculation of the critical nonergodicity parameterComment: 27 pages, 17 figure

Optimization of lipase production by Staphylococcus sp. Lp12

A bacterial strain isolated from an oil contaminated soil, identified as Staphylococcus sp. Lp12 was screened for lipase activity on tributyrin agar and spirit blue agar medium. Maximum lipase production was observed at 48 h of growth (3.5 Eu/ml). Peptone was found to be as an ideal nitrogen source for production at a concentration of 1.0% (4.25 Eu/ml). Addition of any nitrogen source other than peptone to the medium resulted in a significant reduction of enzyme production. Lower lipase production was noted when an inorganic nitrogen source was used as the sole nitrogen source. Starch was used as a major carbon source for optimum production of lipase (4.25 Eu/ml) at a concentration of 1.5%. Of the natural oils, olive oil was able to induce more lipase (4.25 Eu/ml) rather than the oils like groundnut, coconut, castor oils. Basal medium containing tween 80 enhanced lipase production to a significant level. The pH 8 and temperature 45°C were found to be ideal pH and temperature for optimum production of lipase by this strain

El libro de los intentos: ensayo de la pr?ctica docente

203 p. Recurso Electr?nicoEsta investigaci?n titulada ?El libro de los intentos: ensayo de la pr?ctica docente?, narra la b?squeda de la experiencia de la lectura literaria durante algunas clases de Lengua Castellana de la tercera pr?ctica docente, realizada en el a?o 2014 con un grupo de estudiantes del grado octavo de un colegio oficial de Ibagu?. Es una reflexi?n que parti? de las preguntas ?qu? es la literatura?, ?por qu? llevar la literatura al aula? y adem?s ?qu? implica su ense?anza?, ante la ausencia por lo general, de experiencias de lecturas literarias debido a que la literatura se ense?a solo como disciplina. Con una metodolog?a adaptable y fortuita, se logr? intervenir de manera consciente en las din?micas del aula, mediante la estrategia de la lectura en voz alta de distintos cuentos con el objetivo de transformar la pr?ctica durante su camino y la reflexi?n en el proceso. A partir de las respuestas de los estudiantes a dichas preguntas, se lleg? a la conclusi?n de que el concepto de literatura puede y necesita ser reinventado, en la medida que se construye un v?nculo entre: docente, estudiante y obra literaria, representado m?s como un compartir que como un proceso de ense?anza y aprendizaje. As?, una de las conclusiones m?s relevantes, es la necesaria participaci?n del docente en la gestaci?n de espacios que posibiliten la experiencia literaria en los estudiantes; lo que permiti? mirar a la vivencia de la literatura desde otro ?ngulo. Palabras claves: Experiencia de la lectura, Experiencia literaria, Ense?anza, Ensayo, Estudiante, Did?ctica de la Literatura.This research entitled "The book of attempts: essay of the teaching practice", narrates the search of the literary reading experience during some classes of Spanish Language of the third teaching practice carried out in 2014, with a group of students of degree eighth of an official school in Ibagu?. It is a reflection that started with the questions: What is literature? Why bring literature to the classroom? and What does his teaching imply?, in the absence, in general, of literary reading experiences, because literature is taught only as a discipline. Thus, with an adaptive and fortuitous methodology, it was possible to intervene consciously in classroom dynamics, through the strategy of reading aloud different stories with the aim of transforming the practice during their journey and reflection in the process. From the answers of the students to these questions, it was concluded that the concept of literature can and must be reinvented as a link is built between: teacher, student and literary work, represented more as a shared than as a teaching and learning process. Thus, one of the most relevant conclusions is the necessary participation of the teacher in the gestation of spaces that allow the literary experience in the students; what allowed to look at the experience of literature from another angle. Keywords: Reading Experience, Literary experience, Teaching, Essay, Student, Literature Didactics

Birthing practices of traditional birth attendants in South Asia in the context of training programmes

Traditional Birth Attendants (TBA) training has been an important component of public health policy interventions to improve maternal and child health in developing countries since the 1970s. More recently, since the 1990s, the TBA training strategy has been increasingly seen as irrelevant, ineffective or, on the whole, a failure due to evidence that the maternal mortality rate (MMR) in developing countries had not reduced. Although, worldwide data show that, by choice or out of necessity, 47 percent of births in the developing world are assisted by TBAs and/or family members, funding for TBA training has been reduced and moved to providing skilled birth attendants for all births. Any shift in policy needs to be supported by appropriate evidence on TBA roles in providing maternal and infant health care service and effectiveness of the training programmes. This article reviews literature on the characteristics and role of TBAs in South Asia with an emphasis on India. The aim was to assess the contribution of TBAs in providing maternal and infant health care service at different stages of pregnancy and after-delivery and birthing practices adopted in home births. The review of role revealed that apart from TBAs, there are various other people in the community also involved in making decisions about the welfare and health of the birthing mother and new born baby. However, TBAs have changing, localised but nonetheless significant roles in delivery, postnatal and infant care in India. Certain traditional birthing practices such as bathing babies immediately after birth, not weighing babies after birth and not feeding with colostrum are adopted in home births as well as health institutions in India. There is therefore a thin precarious balance between the application of biomedical and traditional knowledge. Customary rituals and perceptions essentially affect practices in home and institutional births and hence training of TBAs need to be implemented in conjunction with community awareness programmes

Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75447/1/j.1399-5448.2009.00526.x.pd

A global 3-D CTM evaluation of black carbon in the Tibetan Plateau

We systematically evaluate the black carbon (BC) simulations for 2006 over the Tibetan Plateau by a global 3-D chemical transport model (CTM) (GEOS-Chem) driven by GEOS-5 assimilated meteorological fields, using in situ measurements of BC in surface air, BC in snow, and BC absorption aerosol optical depth (AAOD). Using improved anthropogenic BC emission inventories for Asia that account for rapid technology renewal and energy consumption growth (Zhang et al., 2009; Lu et al., 2011) and improved global biomass burning emission inventories that account for small fires (van der Werf et al., 2010; Randerson et al., 2012), we find that model results of both BC in surface air and in snow are statistically in good agreement with observations (biases < 15%) away from urban centers. Model results capture the seasonal variations of the surface BC concentrations at rural sites in the Indo-Gangetic Plain, but the observed elevated values in winter are absent. Modeled surface-BC concentrations are within a factor of 2 of the observations at remote sites. Part of the discrepancy is explained by the deficiencies of the meteorological fields over the complex Tibetan terrain. We find that BC concentrations in snow computed from modeled BC deposition and GEOS-5 precipitation are spatiotemporally consistent with observations (<i>r</i> = 0.85). The computed BC concentrations in snow are a factor of 2–4 higher than the observations at several Himalayan sites because of excessive BC deposition. The BC concentrations in snow are biased low by a factor of 2 in the central plateau, which we attribute to the absence of snow aging in the CTM and strong local emissions unaccounted for in the emission inventories. Modeled BC AAOD is more than a factor of 2 lower than observations at most sites, particularly to the northwest of the plateau and along the southern slopes of the Himalayas in winter and spring, which is attributable in large part to underestimated emissions and the assumption of external mixing of BC aerosols in the model. We find that assuming a 50% increase of BC absorption associated with internal mixing reduces the bias in modeled BC AAOD by 57% in the Indo-Gangetic Plain and the northeastern plateau and to the northeast of the plateau, and by 16% along the southern slopes of the Himalayas and to the northwest of the plateau. Both surface BC concentration and AAOD are strongly sensitive to anthropogenic emissions (from China and India), while BC concentration in snow is especially responsive to the treatment of BC aerosol aging. We find that a finer model resolution (0.5° × 0.667° nested over Asia) reduces the bias in modeled surface-BC concentration from 15 to 2%. The large range and non-homogeneity of discrepancies between model results and observations of BC across the Tibetan Plateau undoubtedly undermine current assessments of the climatic and hydrological impact of BC in the region and thus warrant imperative needs for more extensive measurements of BC, including its concentration in surface air and snow, AAOD, vertical profile and deposition