Las condiciones profesionales del traductor especializado: propuesta basada en las TIC.

Uso de herramientas TIC tales como memoria de traducción y gestor terminológico a la traducción especializada. Propuesta didáctica para la formación de traductores, que simula una agencia de traducción y se basa en conocimientos lingüísticos que los alumnos deben adquirir: género, funciones discursivas y metadiscurso interpersonal, que deben utilizar a través de las mencionadas herramientas TIC para crear un patrón metadiscursivo válido y aplicable.Use of ICT tools such as translation memory and terminological administrator to specialized translation. This is a didactic proposal to train translators, that simulates a translation agency. It is based on the linguistic knowledge that students must have, like genre, discursive functions and interpersonal metadiscourse. Translation students must use them through the above mentioned ICT tools in order to create a liable metadiscursive pattern that can be applied to translations

How to blend language and ICT in the didactics of scientific translation

Este capítulo presenta una fusión de la lingüistica aplicada a la traducción científica (análisis del discurso y metadiscurso) y la utilización de las nuevas tecnologías (memorias de traducción, bancos terminológicos). A través del análisis metadiscursivo y la identificación de marcadores en español e inglés, los alumnos crean su propia memoria de traducción y su banco terminológico.This chaper proposes a blend of applied linguistics to scientific translation (discourse and metadiscourse analysis) and some of the new technologies for translation (translation memory and lexical data bank). Through the analysis of metadiscourse in given scientific texts, translators-to-be create their own translation memories and lexical data banks

Impact of Functional Polymorphisms on Drug Survival of Biological Therapies in Patients with Moderate-to-Severe Psoriasis

Biological therapies (BTs) indicated for psoriasis are highly effective; however, not all patients obtain good results, and loss of effectiveness is the main reason for switching. Genetic factors may be involved. The objective of this study was to evaluate the influence of single-nucleotide polymorphisms (SNPs) on the drug survival of tumor necrosis factor inhibitors (anti-TNF) medications and ustekinumab (UTK) in patients diagnosed with moderate-to-severe psoriasis. We conducted an ambispective observational cohort study that included 379 lines of treatment with anti-TNF (n = 247) and UTK (132) in 206 white patients from southern Spain and Italy. The genotyping of the 29 functional SNPs was carried out using real-time polymerase chain reaction (PCR) with TaqMan probes. Drug survival was evaluated with Cox regression and Kaplan-Meier curves. The multivariate analysis showed that the HLA-C rs12191877-T (hazard ratio [HR] = 0.560; 95% CI = 0.40-0.78; p = 0.0006) and TNF-1031 (rs1799964-C) (HR = 0.707; 95% CI = 0.50-0.99; p = 0.048) polymorphisms are associated with anti-TNF drug survival, while TLR5 rs5744174-G (HR = 0.589; 95% CI = 0.37-0.92; p = 0.02), CD84 rs6427528-GG (HR = 0.557; 95% CI = 0.35-0.88; p = 0.013) and PDE3A rs11045392-T together with SLCO1C1 rs3794271-T (HR = 0.508; 95% CI = 0.32-0.79; p = 0.002) are related to UTK survival. The limitations are the sample size and the clustering of anti-TNF drugs; we used a homogeneous cohort of patients from 2 hospitals only. In conclusion, SNPs in the HLA-C, TNF, TLR5, CD84, PDE3A, and SLCO1C1 genes may be useful as biomarkers of drug survival of BTs indicated for psoriasis, making it possible to implement personalized medicine that will reduce financial healthcare costs, facilitate medical decision-making and improve patient quality of life. However, further pharmacogenetic studies need to be conducted to confirm these associations.University of Granada and the Fundación de Investigación Biosanitaria de Andalucía Oriental (FIBAO)Virgen de las Nieves University Hospital Biobank was supported by grants co-funded by ERDF funds (EU) from the Instituto de Salud Carlos III (PT13/0010/0039)

ANÁLISIS DEL PROGRAMA VIVIENDAS ECONÓMICAS DE SENAVITAT PARA LAS FAMILIAS DE LA COMUNIDAD DE SANTA ELENA

En el Paraguay el déficit habitacional de acuerdo con el último censo realizado por la Dirección de Estadísticas y Censos en el años 2012, es de 1.000.000 viviendas en todo el territorio nacional; esta investigación pretende analizar el grado de satisfacción de las familias beneficiadas y si existen dificultades a la hora de postularse para adquirir una vivienda, del programa FONAVIS, el cual otorga subsidios para la construcción de viviendas sociales, destinado a los sectores más vulnerables, que viven en casas de condiciones precarias o en situación de hacinamiento, con el objetivo de reducir la pobreza o pobreza extrema; específicamente en la Ciudad de Santa Elena, Cordillera. La investigación es descriptiva, no experimental, cuali-cuantitativa. La población y la muestra son las personas del barrio Santa Elena de Cordillera. Los programas habitacionales elevan la calidad de vida de las personas, creando nuevos centros urbanos, que garanticen el acceso a los servicios básicos, caminos, salud, educación y seguridad, facilitando la adquisición de una vivienda digna a un costo acorde al nivel socioeconómico de la población, gracias a los subsidios de hasta el 95% el valor total de la construcción, buscando responder a la demanda habitacional a nivel país. La vivienda es un factor de inclusión en la sociedad, contar con una vivienda propia genera mayor confianza y sentido de pertenencia a la comunidad, mitigando en nuestro caso la migración rural-urbana, que generan cinturones de pobrezas en las principales ciudades del país. Las soluciones habitacionales presentadas por la SENAVITAT pretenden ir más allá de la construcción de las casas, dando prioridad a las madres solteras en condiciones de vulnerabilidad y así elevar la calidad de vida de los niños, mejorando el tipo de viviendas a ser entregadas en las zonas rurales

Implementación de círculos de lectura para promover prácticas de literacidad colaborativas como parte de las clases de plan lector de inglés del Colegio del Rosario de Santo Domingo

A lo largo de los años, el aprendizaje colaborativo como un enfoque de enseñanza ha sido de gran preferencia para los modelos pedagógicos de las instituciones educativas del país. No obstante, aunque el Colegio del Rosario de Santo Domingo adoptó este enfoque en las clases de inglés, más específicamente en las prácticas lecto-escriturales, se evidenció que estas se abordaban no sólo de manera individual, sino que además se caracterizaban por ser prescriptivas e instrumentales. Por esta razón, se consideró pertinente la implementación de la estrategia metodológica de “Círculos de lectura”, en las clases de plan lector de inglés, con las estudiantes del grado 1001 entre 15 y 16 años con un nivel de inglés intermedio (B1), por su naturaleza colaborativa. Cabe resaltar que la base teórica y conceptual de esta investigación se centra en algunas de las perspectivas del constructivismo social de Vygotsky, del aprendizaje colaborativo, de los Círculos de lectura y de la literacidad y prácticas de literacidad colaborativas. Es así como esta investigación se propuso tanto identificar los aspectos colaborativos que emergen de la implementación de los Círculos de lectura, como analizar la forma en que estos aspectos podrían promover prácticas colaborativas de literacidad. Esta investigación es de corte cualitativo y adopta algunos aspectos metodológicos de la teoría fundamentada. Los instrumentos para la recolección de datos utilizados consistieron en diarios de campo, los productos de clase de las estudiantes, cuestionarios y una entrevista semiestructurada a la profesora titular. Finalmente, los resultados sugieren que los aspectos didácticos de los círculos de lectura tales como la dinámica de roles y la flexibilidad dieron paso a formas de colaboración por parte de las estudiantes que informaron sus prácticas de literacidad colaborativas.Through the time, Collaborative Learning, as a teaching approach, has been of great preference for pedagogical models in intuitions all over the country. Nonetheless, although Rosario Santo Domingo School adopted this approach in EFL classes, specifically in reading and writing lessons, it was observed that those were addressed not only individually, but also, they were characterized by their prescriptive and instrumental orientation. Therefore, it was considered appropriate to implement the methodological strategy of “Reading Circles”, in reading and writing EFL classes, with 10th grade students at intermediate level (B1), because of its collaborative nature. It is important to highlight that the theoretical and conceptual framework of this research is based on some of the Vygotskyan social constructivist perspectives, collaborative learning groundings, as well as literacy and collaborative literacy practices. Thus, this research was aimed to identify the collaborative traces that emerge from the reading circles implementation, and to analyze the way those features could inform collaborative literacy practices. This qualitative research follows aspects of the grounded theory methodological path. The instruments used for the data collection consisted in journals, students’ products, questionnaires and a semi structured interview. Final outcomes suggest that the reading circles didactic features, such as the dynamic of roles and its flexibility, led to ways of collaboration that subsequently informed students’ collaborative literacy practices.Licenciado (a) en Lenguas ModernasPregrad

Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review

The objective of this systematic review was to provide a compilation of all the literature available on the association between single-nucleotide polymorphisms (SNPs) in the genes involved in the metabolic pathway of vitamin D and overall survival (OS) and progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC). This systematic review was conducted in accordance with the PRISMA guidelines. It included all the literature published up to 1 November 2022 and was carried out in four databases (Medline [PubMed], Scopus,Web of Science, and Embase), using the PICO strategy, with relevant keywords related to the objective. The quality of the studies included was evaluated with an assessment tool derived from the Strengthening the Reporting of Genetic Association Studies (STREGA) statement. Six studies were included in this systematic review. Our findings showed that the BsmI (rs1544410), Cdx-2 (rs11568820), FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236), rs4646536, rs6068816, rs7041, and rs10741657 SNPs in the genes that play a part in vitamin D synthesis (CYP2R1, CYP27B1), transport (GC), and metabolism (CYP24A1), as well as in the vitamin D receptor (VDR), are associated with OS and/or PFS in patients with NSCLC. The SNPs in VDR have been the most extensively analyzed. This systematic review summed up the available evidence concerning the association between 13 SNPs in the main genes involved in the vitamin D metabolic pathway and prognosis in NSCLC. It revealed that SNPs in the VDR, CYP27B1, CYP24A1, GC, and CYP2R1 genes could have an impact on survival in this disease. These findings suggest the identification of prognostic biomarkers in NSCLC patients. However, evidence remains sparse for each of the polymorphisms examined, so these findings should be treated with caution.The Virgen de las Nieves University Hospital Biobank was supported by grants co-funded by ERDF funds (EU) from the Instituto de Salud Carlos III (PT13/0010/0039)

Single Nucleotide Polymorphisms in the Vitamin D Metabolic Pathway and Their Relationship with High Blood Pressure Risk

High blood pressure (HBP) is the leading risk factor for cardiovascular disease (CVD) and all-cause mortality worldwide. The progression of the disease leads to structural and/or functional alterations in various organs and increases cardiovascular risk. Currently, there are significant deficiencies in its diagnosis, treatment, and control. Vitamin D is characterized by its functional versatility and its involvement in countless physiological processes. This has led to the association of vitamin D with many chronic diseases, including HBP and CVD, due to its involvement in the regulation of the renin–angiotensin–aldosterone system. The aim of this study was to evaluate the effect of 13 single nucleotide polymorphisms (SNPs) related to the vitamin D metabolic pathway on the risk of developing HBP. An observational case-control study was performed, including 250 patients diagnosed with HBP and 500 controls from the south of Spain (Caucasians). Genetic polymorphisms in CYP27B1 (rs4646536, rs3782130, rs703842, and rs10877012), CYP2R1 rs10741657, GC rs7041, CYP24A1 (rs6068816, and rs4809957), and VDR (BsmI, Cdx2, FokI, ApaI, and TaqI) were analyzed by real-time PCR using TaqMan probes. Logistic regression analysis, adjusted for body mass index (BMI), dyslipidemia, and diabetes, showed that in the genotypic model, carriers of the GC rs7041 TT genotype were associated with a lower risk of developing HBP than the GG genotype (odds ratio (OR) = 0.44, 95% confidence interval (CI): 0.41–0.77, p = 0.005, TT vs. GG). In the dominant model, this association was maintained; carriers of the T allele showed a lower risk of developing HBP than carriers of the GG genotype (OR = 0.69, 95% CI: 0.47–1.03; TT + TG vs. GG, p = 0.010). Finally, in the additive model, consistent with previous models, the T allele was associated with a lower risk of developing HBP than the G allele (OR = 0.65, 95% CI: 0.40–0.87, p = 0.003, T vs. G). Haplotype analysis revealed that GACATG haplotypes for SNPs rs1544410, rs7975232, rs731236, rs4646536, rs703842, and rs10877012 were associated with a marginally significant lower risk of developing HBP (OR = 0.35, 95% CI: 0.12–1.02, p = 0.054). Several studies suggest that GC 7041 is associated with a lower active isoform of the vitamin D binding protein. In conclusion, the rs7041 polymorphism located in the GC gene was significantly associated with a lower risk of developing HBP. This polymorphism could therefore act as a substantial predictive biomarker of the disease.ERDF funds (EU) from the Instituto de Salud Carlos III (PT13/0010/0039) supported by co-funding grants from the Biobank of the Hospital Universitario Virgen de las Nieves

Implicación de los estudiantes en la definición de salidas profesionales para el Grado de Criminología

Depto. de Sociología AplicadaFac. de Ciencias Políticas y SociologíaFALSEsubmitte

Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease

Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels. In addition to environmental risk factors, genetic predisposition increases the risk; this includes alterations in the vitamin D receptor gene (VDR). These alterations play a key role in modifying vitamin D uptake, being able to modify its function and increasing susceptibility to cardiovascular disorders. The aim of this study was to evaluate the association of polymorphisms in the VDR gene and risk of CVD in a Caucasian population. A retrospective case-control study was conducted comprising 246 CVD patients and 246 controls of Caucasian origin from Southern Spain. The genetic polymorphisms BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232), FokI (rs2228570) and Cdx2 (rs11568820) were determined by means of real-time polymerase chain reaction (PCR) for allelic discrimination using TaqMan® probes. The logistic regression analysis adjusted for body mass index and diabetes revealed that the TT genotype was associated with a higher risk of CVD in both the genotypic model (p = 0.0430; OR = 2.30; 95% CI = 1.06–5.37; TT vs. CC) and the recessive model (p = 0.0099; OR = 2.71; 95% CI = 1.31–6.07; TT vs. C). Haplotype analysis revealed that the haplotype GAC (p = 0.047; OR = 0.34; 95% CI = 0.12–0.98) was associated with increased risk of CVD. The VDR polymorphisms FokI (rs2228570) was significantly associated with the development of CVD. No influence was observed of the VDR polymorphisms BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) on the risk of developing CVD in the patients studied.ERDF funds (EU) from the Instituto de Salud Carlos III PT13/0010/003

A 16-week multicomponent exercise training program improves menopause-related symptoms in middle-aged women. The FLAMENCO project randomized control trial

Abstract Objective: To investigate the influence of a supervised multicomponent exercise training program on menopause-related symptoms, particularly vasomotor symptoms (VMS), in middle-aged women. Methods: A total of 112 middle-aged women (mean age 52 4 y old, age range 45-60 y) from the FLAMENCO project (exercise [n ¼ 59] and counseling [n ¼ 53] groups) participated in this randomized controlled trial (perprotocol basis). The exercise group followed a multicomponent exercise program composed of 60-minute sessions 3 days per week for 16 weeks. The 15-item Cervantes Menopause and Health Subscale was used to assess the frequency of menopause-related symptoms. Results: After adjusting for body mass index and Mediterranean diet adherence, the subscales measuring menopause-related symptoms and VMSs decreased 4.6 more in the exercise group compared to the counseling group (between-group differences [B]: 95% CI: -8.8 to -0.2; P ¼ 0.040). The exercise group also showed significant improvements in the subscales of couple relationships (between-group differences [B]: -1.87: 95% CI: -3.29 to - 0.45; P ¼ 0.010), psychological state (between-group differences [B]: -2.3: 95% CI: -5 to -0.2; P ¼ 0.035), and VMSs (between-group differences [B]: -4.5: 95% CI: -8.8 to -0.2; p ¼ 0.040) in the Cervantes Menopause and Health Subscale compared with the counseling group. Conclusions: A 16-week multicomponent physical exercise program showed a positive effect on menopauserelated symptoms especially in couple relationships, psychological state, and VMS, among 45 to 60 year old women