Helplessness

Journal #11 from Media Rise's Quarantined Across Borders Collection by Venkata Raju. From India. Quarantined in United States.A poem about the use of social media during the quarantine and how we can find hope in the matter.Media Rise Publications. Quarantined Across Borders Collection. Edited by Dr Srividya "Srivi" Ramasubramanian

Helplessness

Journal #11 from Media Rise's Quarantined Across Borders Collection by Venkata Raju. From India. Quarantined in United States.A poem about the use of social media during the quarantine and how we can find hope in the matter.Media Rise Publications. Quarantined Across Borders Collection. Edited by Dr Srividya "Srivi" Ramasubramanian

A seismic study of the Iceland-Faeroes ridge

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Preliminary Phytochemical and Antimicrobial Properties of Pueraria tuberosa (Willd.) DC: A Potential Medicinal Plant

In vitro antimicrobial and chemical properties of petroleum ether, ethyl acetate and ethanol extracts of Pueraria tuberosa were evaluated. Among the test samples ethyl acetate extract showed pronounced antimicrobial activity, while ethanol extract exhibited the least activity and petroleum ether extract failed to inhibit the test pathogens. Preliminary phytochemical analysis of extracts revealed the presence of antimicrobial compounds such as alkaloids, flavonoids, coumarins, volatile oils and glycosides. The phenolic compounds and flavonoids were abundant in ethyl acetate extract when compared to other extracts. The broad spectrum of antimicrobial activity of ethyl acetate extract may be due to the presence of flavonoids. Based on the observations, P. tuberosa appears to be a valuable source for antimicrobial principles

Traditional Medicine Used by the Adivasis of Eastern Ghats, Andhra Pradesh - For Bone

The present survey provides information on the therapeutic properties of 21 crude drugs used for bone fractures by the natives of Eastern Ghats. Of the twenty one species that are presented here, fourteen had not been previously reported. Information on botanical name, vernacular name, family, part used, mode of drug preparation and administration is provided

Preliminary Phytochemical Evaluation of Certain Anticancer Crude Drugs Used by Adivasis of Rayalaseema Region, Andhra Pradesh, India

The present paper deals with preliminary phytochemical evaluation of certain crude drugs used for cancer. Based on the folklore data obtained from adivasis of Rayalaseema region, Andhra Pradesh, 15 species were collected in the forests of Eastern Ghats in the region. Three species were recorded as new formulations, which are hither to not reported earlier. The preliminary phytochemical screening was conducted on the drug samples, and composition of various groups of constituents was discussed

Taxonomic Validation of Crude Drugs used for Poisonous Bites by Adivasis of Rayalaseema Region, Andhra Pradesh

The present report deals with the phytotherapeutic properties of certain potential anti-poisonous crude drugs used by the Adivasis, inhabited in the forests of Rayalaseema region of Andhra Pradesh. The critical taxonomic analysis yielded twenty species belonging to 17 families of angiosperms used for poisonous bites. The majority of drug formulations (14 spp.) were administered as antidotes for snake bites

A comparative pharmacokinetics study of Ashwagandha (Withania somnifera) Root Extract sustained-release capsules: an open-label, randomized, two treatment, two-sequence, two period, single-dose crossover clinical study

Background: In this open-label, randomized, balanced, two-treatment, two-sequence, two-period, crossover, single-dose oral comparative pharmacokinetics study, the pharmacokinetics, safety, and tolerability of test product ‘ashwagandha (Withania somnifera)’ root extract sustained release capsule 300 mg (Prolanza™), each containing 15 mg withanolides (administered dose: 2×15 mg) was compared with that of a reference product (organic KSM-66 ashwagandha extract [vegan] capsule, each containing 15 mg withanolides [administered dose: 2×15 mg]).Methods: Total 14 healthy men were randomized to receive either the test or the reference product as a single dose of 2 capsules in sequence, administered under fasting conditions. Plasma concentrations of total withanolides, withanolide A and 12-deoxywithastramonolide were measured using validated liquid chromatography–mass spectroscopy/mass spectroscopy.Results: The test product had higher relative absorption, better relative bioavailability, and longer elimination half-life indicating a sustained-release profile compared to reference. Specifically, the relative bioavailability of the test formulation was 12, 44, and 11 times higher for total withanolides, withanolide A and 12-deoxywithastramonolide, respectively. No adverse events were reported during the study.Conclusions: The sustained-release profile of the test product, compared to reference product, will provide more long-lasting therapeutic effects from a single daily dose (Retrospectively applied on Clinical Trials Registry - India [CTRI]. Application reference number: REF/2020/03/032408). The study reports the unique sustained release formulation of Withania somnifera (Ashwagandha) root extract. The pharmacokinetic study also reports for first time, the successful plasma estimation of withanolide A and 12-deoxywithastraamonolide, the major phytoactives of ashwagandha

Body Composition and Leptin in Renal Transplantation.

INTRODUCTION : Weight gain is common after renal transplantation, influenced by improved appetite and a reversal of the uremic state. Renal transplant patients are at risk for increased weight, centripetal obesity and muscle atrophy because of their long-term glucocorticoid requirements. Such changes in body composition are associated with an increased risk of cardiovascular complications, which is a major cause of morbidity and mortality in renal transplantation since infective complications have decreased with newer immunosuppressive medication and therapeutic drug level monitoring. Body composition data might provide insight in to the relation with outcome, survival and post transplant complications and it might affect approaches to nutritional therapy and to therapy in the field of physical activity.1 AIM : To assess the changes in body composition and leptin in the early post transplant period and to validate anthropometry in renal allograft recipients. PATIENTS AND METHODS : Consecutive renal allograft recipients were assessed prospectively at baseline, 3 & 6 months post-transplant by anthropometry, DEXA and serum leptin levels. RESULTS : 62 recipients (M:F=3:1, mean age 33.4±11.2 years), had a mean weight of 52±10.1, 56.8±9.3 and 57.7±9.6 kg at baseline, 3 & 6 months, respectively (p<0.01). The mean body fat at baseline, 3 & 6 months were 11.1±5.7, 13.9±5.7 and 14.5±6.2 kg respectively (p<0.001). The fat increment in arms, legs and trunk were 37.4%, 31.6% and 36.6% respectively. Skin fold thickness correlated well with fat (measured by DEXA) at all times (ICC=0.9, p<0.001). There was a 3.8% increase in lean body mass by 6 months (p<0.01) predominantly in legs. Anthropometry underestimated lean body mass. Total bone mineral content decreased from 1.92±0.34 to 1.85±0.31 kg (p=0.001) by 6 months, with significant reductions in spine (6.7%). The mean leptin levels at baseline, 3 and 6 months were 5.3±7.9, 6.0±8.4 and 15.4±17.4ng/ml respectively (p<0.05). At all times, leptin levels positively correlated with total body and regional fat content (p<0.01). CONCLUSIONS : Post renal transplant, patients gain significant amount of weight, mostly due to accumulation of the fat, especially around arms & trunk .There is overall decrease in bone mineral content, predominantly in the spine. Anthropometric measurements for fat assessment are a reasonable substitute for DXA. Leptin levels correlate with body fat content

A VALIDATED RP-HPLC METHOD FOR IMPURITY PROFILING OF SODIUM NITROPRUSSIDE IN INJECTION DOSAGE FORM

Objective: The main objective of this research work is to develop and validate a single reverse-phase high-performance liquid chromatography (RP-HPLC) method. This method should becapable of quantifying all the known, as well as other possible degradation impurities of sodium nitroprusside (SNP) in its injection formulation. Methods: Of allmethod development trails, we have observed better separations between known and degradation impuritiesin Inert sustain C18, (250 x 4.6) mm, 5 µm column at 30 °C temperature. Isocratic elution was carried out by using pH 8.6 phosphate buffer and acetonitrile in the ratio of 65:35 %v/v with a flow rate of 0.8 ml/min. The detection was carried out at 220 nm, with an injection volume of 10 µl. Results: In the proposed method, SNP was eluted at 22.5 min. Nitrite, nitrate, and ferrocyanide were linear from 0.25 to 37 μg/ml, ferricyanide was linear from 1.0 to 37 μg/ml, and SNP was linear from 0.75 to 37 μg/ml. The % RSD for six spiked samples (precision)was found to be less than 0.5 %. Accuracy was performed for known impurities from LOQ to 150 % for a 0.5 % specification level. The resultswere found to be in the acceptance range of 90-110 %. The LOQ concentration of nitrite, nitrate, and ferrocyanide was 0.25 μg/ml each,LOQ offerricyanide and SNP was found to be 1.0 μg/ml and 0.75 μg/ml, respectively. The SNP injection samples were exposed to different degradation conditions, and the results were found specific in the proposed methodology. Conclusion: The proposed RP-HPLC method is specific, precise, accurate, linear, stable, and robust for quantification of known and other possible degradation impurities in SNP injection formulation