Parry Romberg Syndrome with localized scleroderma: a case report

Parry Romberg syndrome(PRS) is a rare acquired poorly understood neurocutaneous syndrome of unknown etiology characterized by slow progressive atrophic changes commonly affecting one half of the face. The exact incidence and etiology towards the syndrome remains unclear. Apart from the multifactorial etiology proposed, the possible primary cause is mainly attributed to the cerebral disturbance of the fat metabolism. The syndrome over - laps with "en coup de sabre" morphea, with an ill defined relationship existing between the two. Parry Romberg Syndrome is an invalidating lesion that may be associated with different neurological, cutaneous, ocular, dental and autoimmune abnormalities. This report presents one rare case of 22 years old female patient with Parry Romberg syndrome associated with localized scleroderma, accompanied by a brief review of literature with classical clinical, radiographic, histological findings and the treatment of progressive hemifacial atrophy

An Adaptive Design Methodology for Reduction of Product Development Risk

Embedded systems interaction with environment inherently complicates understanding of requirements and their correct implementation. However, product uncertainty is highest during early stages of development. Design verification is an essential step in the development of any system, especially for Embedded System. This paper introduces a novel adaptive design methodology, which incorporates step-wise prototyping and verification. With each adaptive step product-realization level is enhanced while decreasing the level of product uncertainty, thereby reducing the overall costs. The back-bone of this frame-work is the development of Domain Specific Operational (DOP) Model and the associated Verification Instrumentation for Test and Evaluation, developed based on the DOP model. Together they generate functionally valid test-sequence for carrying out prototype evaluation. With the help of a case study 'Multimode Detection Subsystem' the application of this method is sketched. The design methodologies can be compared by defining and computing a generic performance criterion like Average design-cycle Risk. For the case study, by computing Average design-cycle Risk, it is shown that the adaptive method reduces the product development risk for a small increase in the total design cycle time.Comment: 21 pages, 9 figure

Supported TritonX-100 Polyaniline Nano-Porous Electrically Active Film onto Indium-Tin-Oxide Probe for Sensors Application

Supported tritonX100 polyaniline nano-porous electrically active film has been fabricated successfully onto indium-tin-oxide conducting probe using electrochemical polymerization process. The doping of TX-100 in the polymeric network of PANI was suggested using cyclic voltammeter, UV-vis spectroscopy, and Fourier Transform Infrared spectroscopy. The change in the surface morphology of PANI thin film due to incorporation of tritonX-100 was investigated using Atomic Forced Microscopy and porosity has been confirmed scanning electron microscopy, respectively. The surface morphology, uniformly disperse hexagonal close packing of TX-100 in PANI matrices due to the incorporation of TX-100 in polymeric network of PANI was confirmed by Atomic Force Microscopy. The electrical conductivity of PANI-TX-100 increases from 1.06 × 10�–2 S/cm�–1 to 4.95 × 10�–2 S/cm�–1 as the amount of TX-100 increases during the polymerization. The change in the morphology and electrical conductivity of PANI due to incorporation of TX-100 prove as a promising material for the sensing application

A FlexiWork App – An Innovative Way to Measure and Monitor Productivity while WFH for Academicians

Academics need better workplace flexibility as their brains can never wholly switch off from work. Therefore, flexible working arrangements (FWA) are linked with enhanced productivity. This research proposes a self-monitoring tool using a mobile application. FlexiWork App is a self-monitoring application designed for an academic to self-measure the impact of workplace flexibility on productivity; and secondly, for the institution to monitor the academic's key performance indicator (KPI) achievement. Hence, this application will benefit both the academics and the university in monitoring the KPI of the staff. Keywords: Flexible Working, Productivity, Academic, Mobile Apps eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under the responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i21.371

Chitosan/polyaniline hybrid conducting biopolymer base impedimetric immunosensor to detect Ochratoxin-A

Chitosan (CS)–polyaniline (PANI) hybrid conducting biopolymer film was obtained on indium–tin-oxide (ITO) electrode using electrochemical polymerization process. Fourier transform infrared (FT-IR) spectra of PANI–CS had showed covalent and hydrogen binding between PANI and CS molecules. Electrochemical impedance spectroscopy (EIS) measurements had showed lowcharge transfer resistance (RCT) of PANI–CS and PANI. Successive rabbit antibody (IgGs) immobilizationonPANI–CS, CS and PANI matrixes surfacewere confirmed with FT-IR and EIS measurements. Ochratoxin-A (OTA) interaction with IgGs had increased RCT values and showed linear response up to 10 ng/mL OTA concentration in electrolyte. Relative change in RCT was higher in PANI–CS due to higher proportion of carboxylic and hydroxyl functionalities at PANI–CS matrix surfaces. The absolute sensitivity of PANI, CS, and PANI–CSwere 16±6, 22±9 and 53±8�mL/ng, respectively derived fromslope of linear response up to 10 ng/mL with 1 ng/mL minimum detection limit

Conversion of Food Processing Waste to Bioenergy: Bangladesh Perspective

Microbial fuel cell (MFC) is an attractive renewable and sustainable technology to meet up the drastic energy crisis of the world through waste water treatment. This Bioelectrochemical system (BES) converts biomass spontaneously into electricity by the metabolic activity of microorganisms. Food processing industry generally discharges large volume of wastewater, which creates adverse financial and ecological impacts to the industry and environment. In this present contribution, electricity production from food processing industry wastewater that serves as substrates in MFCs was investigated. Dual chambered mediator-less MFC was designed and fabricated using locally available materials. Performance of the MFC was evaluated by measuring potential parameters, such as current generation, current density, change in pH, and change in chemical oxygen demand at different operating conditions. Polarization experiments were conducted to find the maximum power density. Current generation increased with increasing sludge loading, and maximum results were recorded as 90 µA with 9 g of sludge and optimum pH value 8 in the anode chamber. This study documented a maximum power density of 7.42 mW/m2 with the corresponding current density of 25 mA/m2. Citation: Amin, M. S. A., Talukder, M. J., Raju, R. R., and Khan, M. M. R. (2019). Conversion of Food Processing Waste to Bioenergy: Bangladesh Perspective. Trends in Renewable Energy, 5(1), 1-11. DOI: 10.17737/tre.2019.5.1.008

Nanomolar Detection of Glutamate at a Biosensor Based on Screen-Printed Electrodes Modified with Carbon Nanotubes

The flow injection analysis (FIA) of monosodiuml-glutamate (MSG) was performed electrochemically using a biosensor based on screen-printed electrodes containing carbon nanotubes (CNT). The sensor was fabricated by simply adsorbing glutamate oxidase (GlutOx) on the electrode surface. The resulting device displayed excellent electroanalytical properties toward the determination ofl-glutamate in a wide linear range (0.01–10mM) with low detection limit (10 nM, S/N !3), fast response time ( 5 s), and good operational and long-term stability. The CNT-modified screen-printed electrodes have a potential to be of general interest for easy preparation of electrochemical sensors and biosensors relevant for biomedical applications

Understanding Pharmaceutical Quality by Design

This review further clarifies the concept of pharmaceutical quality by design (QbD) and describes its objectives. QbD elements include the following: (1) a quality target product profile (QTPP) that identifies the critical quality attributes (CQAs) of the drug product; (2) product design and understanding including identification of critical material attributes (CMAs); (3) process design and understanding including identification of critical process parameters (CPPs), linking CMAs and CPPs to CQAs; (4) a control strategy that includes specifications for the drug substance(s), excipient(s), and drug product as well as controls for each step of the manufacturing process; and (5) process capability and continual improvement. QbD tools and studies include prior knowledge, risk assessment, mechanistic models, design of experiments (DoE) and data analysis, and process analytical technology (PAT). As the pharmaceutical industry moves toward the implementation of pharmaceutical QbD, a common terminology, understanding of concepts and expectations are necessary. This understanding will facilitate better communication between those involved in risk-based drug development and drug application review

:e313-6. Parry Romberg Syndrome: A rare entity Journal section: Oral Medicine and Pathology Publication Types: Case Report Parry Romberg Syndrome with localized scleroderma: a case report

Abstract Parry Romberg syndrome(PRS) is a rare acquired poorly understood neurocutaneous syndrome of unknown etiology characterized by slow progressive atrophic changes commonly affecting one half of the face. The exact incidence and etiology towards the syndrome remains unclear. Apart from the multifactorial etiology proposed, the possible primary cause is mainly attributed to the cerebral disturbance of the fat metabolism. The syndrome overlaps with "en coup de sabre" morphea, with an ill defined relationship existing between the two. Parry Romberg Syndrome is an invalidating lesion that may be associated with different neurological, cutaneous, ocular, dental and autoimmune abnormalities. This report presents one rare case of 22 years old female patient with Parry Romberg syndrome associated with localized scleroderma, accompanied by a brief review of literature with classical clinical, radiographic, histological findings and the treatment of progressive hemifacial atrophy