Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

Alzheimer’s disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we reviewed the utility of plant polyphenols in regulating proliferation and differentiation of stem cells for inducing brain self-repair in AD and multiple sclerosis. Firstly, we discussed the genetic, physiological, and environmental factors involved in the pathophysiology of both the disorders. Next, we reviewed various stem cell therapies available and how they have proved useful in animal models of AD and multiple sclerosis. Lastly, we discussed how polyphenols utilize the potential of stem cells, either complementing their therapeutic effects or stimulating endogenous and exogenous neurogenesis, against these diseases. We suggest that polyphenols could be a potential candidate for stem cell therapy against neurodegenerative disorders

Primary tuberculosis of epiglottis-A case report

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Effect of base paper characteristics on coated paper quality

309-316The quality of coated paper is mainly governed by the characteristics of base paper. The three main base paper properties which contribute to the variations on coat weight and print non-uniformity in coated paper are roughness, absorbency and sheet matrix formation. Increase in roughness of base paper gives coated paper of lower smoothness and gloss at a particular coat weight. Along with roughness the compressibility of base paper also plays important role. Porosity and sizing degree which affect absorbency of base paper also affect the coated paper quality. Porosity of base paper has minor effect on coated paper roughness. The gloss of coated paper is improved with sizing and sheet densification. Sheet matrix non-uniform formation has little effect on coated paper gloss, however, it adversely affects the smoothness and print uniformity. Loading of base paper with PCC gives better effect on brightness, picking velocity and print saturation density than GCC and Talc