CEO scanning behaviors, self-efficacy, and SME innovation and performance: An examination within a declining industry

Studying the CEOs of small and medium enterprises (SMEs) in the US metalcasting industry—an industry that has been steadily declining for several years—we develop a theoretical model to examine how CEO scanning behaviors in the form of scanning intensity and proactiveness influence self-efficacy, which in turn influences firm innovation and performance. We extend theory and research by (a) demonstrating of the role and influence of SME CEOs over firm innovation and performance in declining industries, (b) illustrating how scanning provides social learning opportunities for CEOs that enhance their levels of self-efficacy, and (c) showing that self-efficacy mediates the effects of scanning on firm innovation and performance

Climate change awareness among the livestock rearers of east coast of India

The phenomenon of global climate change is directly affecting the livestock production system world overall. Therefore, understanding the changing climatic scenario by the millions of resource poor livestock rearers across the east coast of India found to be imperative to get information for strategic planning to improve the livelihoods of rural people. But, systematic methodology to assess climatic change awareness among the livestock rearers is currently not available. Therefore, a psychometric scale entitled “Climate Change Awareness Scale” was developed and applied among the randomly selected 480 livestock rearers of eastern coastal region of India. Results reflected majority of the population exhibit their strong level of awareness towards changing climatic scenario in general and particularly towards broad spectrum of climate change like causes, features, effects and impacts. It was also found that 37.188% of livestock rearers of coastal region were having higher level of awareness followed by 31.973% and 30.839% were having lower and medium level of awareness. Comparisons of state of awareness with the factual climatic data validated farmers’ claim and established the authenticity of the psychometric tool. Hence, this study will provide a significant tool for researchers and policy makers to assess state of climate change awareness among the end users and to develop appropriate adaptation strategies to minimize the risk of livestock sector to climate change

Febuxostat Modulates MAPK/NF- κ

Xanthine oxidase and xanthine dehydrogenase have been implicated in producing myocardial damage following reperfusion of an occluded coronary artery. We investigated and compared the effect of febuxostat and allopurinol in an experimental model of ischemia-reperfusion (IR) injury with a focus on the signaling pathways involved. Male Wistar rats were orally administered vehicle (CMC) once daily (sham and IR + control), febuxostat (10 mg/kg/day; FEB10 + IR), or allopurinol (100 mg/kg/day; ALL100 + IR) for 14 days. On the 15th day, the IR-control and treatment groups were subjected to one-stage left anterior descending (LAD) coronary artery ligation for 45 minutes followed by a 60-minute reperfusion. Febuxostat and allopurinol pretreatment significantly improved cardiac function and maintained morphological alterations. They also attenuated oxidative stress and apoptosis by suppressing the expression of proapoptotic proteins (Bax and caspase-3), reducing TUNEL-positive cells, and increasing the level of antiapoptotic proteins (Bcl-2). The MAPK-based molecular mechanism revealed suppression of active JNK and p38 proteins concomitant with the rise in ERK1/ERK2, a prosurvival kinase. Additionally, a reduction in the level of inflammatory markers (TNF-α, IL-6, and NF-κB) was also observed. The changes observed with febuxostat were remarkable in comparison with those observed with allopurinol. Febuxostat protects relatively better against IR injury than allopurinol by suppressing inflammation and apoptosis mediating the MAPK/NF-κBp65/TNF-α pathway

CEO scanning behaviors, self-efficacy, and SME innovation and performance: An examination within a declining industry

Studying the CEOs of small and medium enterprises (SMEs) in the US metalcasting industry—an industry that has been steadily declining for several years—we develop a theoretical model to examine how CEO scanning behaviors in the form of scanning intensity and proactiveness influence self-efficacy, which in turn influences firm innovation and performance. We extend theory and research by (a) demonstrating of the role and influence of SME CEOs over firm innovation and performance in declining industries, (b) illustrating how scanning provides social learning opportunities for CEOs that enhance their levels of self-efficacy, and (c) showing that self-efficacy mediates the effects of scanning on firm innovation and performance

Slit lamp ophthalmodynamometry in internal carotid artery insufficiency

Slit lamp ophthalmodynamometry was done by Dynoptor instrument in 6 cases of internal carotid artery, insufficiency, 18 cases of middle cerebral artery thrombosis and 20 control cases free from neurological disease. The average difference between the ophthalmic artery pressures of the two sides was 7.6% (diastolic) and 4.8% (systolic) in control cases. It was 6.6% (diastolic) and 4.6% (systolic) in cases of middle cerebral artery thrombosis. This difference was much higher in cases of^-sub internal carotid artery insufficiency (41.3% ′diastolic and 25.4% in systolic); thus elucidating the role of ophthalmodynamometry as a non-invasive technique in diagnosis of these cases

Cardioprotective effect of root extract of <i>Picrorhiza kurroa</i> (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats

694-701Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative stress by restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase enzymes except reduced glutathione content. P. kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and lactate dehydrogenase enzymes. The results suggest that <i style="mso-bidi-font-style: normal">P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties

Seabuckthorn Pulp Oil Protects against Myocardial Ischemia–Reperfusion Injury in Rats through Activation of Akt/eNOS

Seabuckthorn (SBT) pulp oil obtained from the fruits of seabuckthorn [Hippophae rhamnoides L. (Elaeagnaceae)] has been used traditionally for its medicinal and nutritional properties. However, its role in ischemia–reperfusion (IR) injury of myocardium in rats has not been elucidated so far. The present study reports the cardioprotective effect of SBT pulp oil in IR-induced model of myocardial infarction in rats and underlying mechanism mediating activation of Akt/eNOS signaling pathway. Male albino Wistar rats were orally administered SBT pulp oil (5, 10, and 20 ml/kg/day) or saline for 30 days. On the day 31, ischemia was induced by one-stage ligation of left anterior descending coronary artery for 45 min followed by reperfusion for 60 min. SBT pulp oil pretreatment at the dose of 20 ml/kg observed to stabilize cardiac function and myocardial antioxidants such as glutathione, superoxide dismutase, catalase, and inhibited lipid peroxidation evidenced by reduced malondialdehyde levels as compared to IR-control group. SBT pulp oil also improved hemodynamic and contractile function and decreased tumor necrosis factor and activities of myocyte injury marker enzymes; lactate dehydrogenase and creatine kinase-MB. Additionally, a remarkable rise in expression of pAkt–eNOS, Bcl-2 and decline in expression of IKKβ/NF-κB and Bax was observed in the myocardium. The histopathological and ultrastructural salvage of cardiomyocytes further supports the cardioprotective effect of SBT pulp oil. Based on findings, it can be concluded that SBT pulp oil protects against myocardial IR injury mediating favorable modulation of Akt-eNOS and IKKβ/NF-κB expression

A folding transition underlies the emergence of membrane affinity in amyloid-β

Small amyloid-β (Aβ) oligomers have much higher membrane affinity compared to the monomers, but the structural origin of this functional change is not understood. We show that as monomers assemble into small n-mers (n &#60; 10), Aβ acquires a tertiary fold that is consistent with the mature fibrils. This is an early and defining transition for the aggregating peptide, and possibly underpins its altered bioactivity