694-701Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed
significant change, however, isoproterenol (ISP) administration resulted in
hemodynamic and left ventricular dysfunction, oxidative stress, and lipid
peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment.
Pre-treatment significantly attenuated the ISP-induced oxidative stress by
restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase
enzymes except reduced glutathione content. P.
kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid
peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and
lactate dehydrogenase enzymes. The results suggest that <i style="mso-bidi-font-style:
normal">P. kurroa root extract possesses significant cardioprotective
effect, which may be attributed to its antioxidant, anti-peroxidative, and
myocardial preservative properties