On the balance energy and nuclear dynamics in peripheral heavy-ion collisions

We present here the system size dependence of balance energy for semi-central and peripheral collisions using quantum molecular dynamics model. For this study, the reactions of $Ne^{20}+Ne^{20}$, $Ca^{40}+Ca^{40}$, $Ni^{58}+Ni^{58}$, $Nb^{93}+Nb^{93}$, $Xe^{131}+Xe^{131}$ and $Au^{197}+Au^{197}$ are simulated at different incident energies and impact parameters. A hard equation of state along with nucleon-nucleon cross-sections between 40 - 55 mb explains the data nicely. Interestingly, balance energy follows a power law $\propto{A^{\tau}}$ for the mass dependence at all colliding geometries. The power factor $\tau$ is close to -1/3 in central collisions whereas it is -2/3 for peripheral collisions suggesting stronger system size dependence at peripheral geometries. This also suggests that in the absence of momentum dependent interactions, Coulomb's interaction plays an exceedingly significant role. These results are further analyzed for nuclear dynamics at the balance point.Comment: 13 pages, 9 figures Accepted in IJMPE (in press

Isospin effects on the energy of vanishing flow in heavy-ion collisions

Using the isospin-dependent quantum molecular dynamics model we study the isospin effects on the disappearance of flow for the reactions of $^{58}Ni$ + $^{58}Ni$ and $^{58}Fe$ +$^{58}Fe$ as a function of impact parameter. We found good agreement between our calculations and experimentally measured energy of vanishing flow at all colliding geometries. Our calculations reproduce the experimental data within 5%(10%) at central (peripheral) geometries

Resorption in Endodontics

<p>Root resorption (RR) refers to noninfectious damage related to the loss of hard and soft dental tissue that results from clastic cell activity. It is observed as a pathologic process that is predominantly asymptomatic in the permanent dentition and physiological during the shedding of primary teeth.</p&gt

Canonical Wnt/beta-catenin signaling activation in soft-tissue sarcomas: A comparative study of synovial sarcoma and leiomyosarcoma

Background: Previous studies have shown that aberrant activation of the Wnt/beta-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for novel molecular therapies. Objective: We investigate the level of Wnt/beta-catenin pathway activation present in leiomyosarcomas relative to synovial sarcomas, using expression of LEF1 and beta-catenin as surrogates. Methods: Cancer outlier profile analysis was performed on messenger RNA expression datasets in Oncomine (70 synovial sarcomas, 178 leiomyosarcomas). Results for LEF1 and beta-catenin messenger RNA expression were reported in terms of median-centered intensity. Separate immunohistochemical studies were performed on tissue microarrays created from 77 synovial sarcomas and 89 leiomyosarcomas using antibodies to LEF1 and beta-catenin. Tumors with unequivocal strong nuclear staining involving > 5% of cells were interpreted as positive. Results: Cancer outlier profile analysis demonstrated a higher level of LEF1 messenger RNA expression in synovial sarcomas than in leiomyosarcomas (p < 0.0001), but showed no significant difference in beta-catenin messenger RNA expression (p = 0.868). Immunohistochemistry showed most synovial sarcomas had strong nuclear expression of LEF1 (79%) and beta-catenin (84%), while a small minority of leiomyosarcomas had strong nuclear expression of LEF1 (5%) and beta-catenin (6%). Conclusion: These results provide further evidence that aberrant activation of the Wnt/beta-catenin pathway is present in most synovial sarcomas, but not in most leiomyosarcomas. While targeting the constituents of this pathway might be effective in the treatment of synovial sarcomas, it is not likely to be an effective strategy in the treatment of leiomyosarcomas

SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy

Histone deacetylase inhibitors (HDACi) can reverse chemoresistance, enhance chemotherapy-induced cytotoxicity, and reduce sarcoma proliferation in cell lines and animal models. We sought to determine the safety and toxicity of mocetinostat and its ability to reverse chemoresistance when administered with gemcitabine in patients with metastatic leiomyosarcoma resistant to prior gemcitabine-containing therapy. Participants with metastatic leiomyosarcoma received mocetinostat orally, 70 mg per day, three days per week, increasing to 90 mg after three weeks if well tolerated. Gemcitabine was administered at 1,000 mg/m2 intravenously at 10 mg/m2/minute on days five and 12 of every 21-day cycle. Disease response was evaluated with CT or MRI. Twenty participants with leiomyosarcoma were evaluated for toxicity. Median time to disease progression was 2.0 months (95% CI 1.54–3.12). Eighteen participants were evaluated for radiologic response by RECIST 1.1. Best responses included one PR and 12 SD. Tumor size reduced in 3 patients. Most common toxicities were fatigue, thrombocytopenia, anemia, nausea, and anorexia. One patient experienced a significant pericardial adverse event. No study-related deaths were observed. Rechallenging with gemcitabine by adding mocetinostat was feasible and demonstrated modest activity in patients with leiomyosarcoma. Further studies are needed to better define the role of HDAC inhibitors in patients with metastatic leiomyosarcoma

Pediatric Sepsis Guidelines: Summary for resource-limited countries

Justification: Pediatric sepsis is a commonly encountered global issue. Existing guidelines for sepsis seem to be applicable to the developed countries, and only few articles are published regarding application of these guidelines in the developing countries, especially in resource-limited countries such as India and Africa. Process: An expert representative panel drawn from all over India, under aegis of Intensive Care Chapter of Indian Academy of Pediatrics (IAP) met to discuss and draw guidelines for clinical practice and feasibility of delivery of care in the early hours in pediatric patient with sepsis, keeping in view unique patient population and limited availability of equipment and resources. Discussion included issues such as sepsis definitions, rapid cardiopulmonary assessment, feasibility of early aggressive fluid therapy, inotropic support, corticosteriod therapy, early endotracheal intubation and use of positive end expiratory pressure/mechanical ventilation, initial empirical antibiotic therapy, glycemic control, and role of immunoglobulin, blood, and blood products. Objective: To achieve a reasonable evidence-based consensus on the basis of published literature and expert opinion to formulating clinical practice guidelines applicable to resource-limited countries such as India. Recommendations: Pediatric sepsis guidelines are presented in text and flow chart format keeping resource limitations in mind for countries such as India and Africa. Levels of evidence are indicated wherever applicable. It is anticipated that once the guidelines are used and outcomes data evaluated, further modifications will be necessary. It is planned to periodically review and revise these guidelines every 3-5 years as new body of evidence accumulates