DEVELOPMENT, OPTIMIZATION AND EVALUATION OF DIFFERENT HERBAL FORMULATIONS FOR WOUND HEALING

Objective: This study was done for comparative evaluation of different herbal formulations used for topical delivery of therapeutic agents at the time of injury to accelerate skin repair in the shortest time possible, with minimal pain, discomfort and scarring to the patient during the wound healing process.Methods: Topical application of ointments and gels prepared from the methanolic extract of Aegle marmelos leaves and Mucuna pruriens seeds were formulated and evaluated for its efficacy and safety. General formulation approaches towards achieving optimum physical properties and topical delivery characteristics for an active wound healing dosage form were considered for different herbal formulations.Results: All formulation showed good stability during storage and no major changes observed after carrying out other physiochemical evaluations and during an entire storage period. Differences in wound healing were observed between the various treatments and compared to the herbal formulation which has promising effect on the wound healing process.Conclusions: The results obtained were encouraging and gel-based formulations produced better wound healing than emulsifying ointment formulations. The results demonstrated that the tested hydrogel had promising healing effect in skin injuries and it will aid in identifying and targeting the many aspects of the complex wound healing process

DEVELOPMENT OF FLOATING GASTRORETENTIVE DRUG DELIVERY SYSTEM BASED ON A NOVEL EXCIPIENT FOR METFORMIN HYDROCHLORIDE USING MIXTURE DESIGN

Objective: The present study aimed to develop a new SR metformin hydrochloride (MH) gastroretentive formulation with novel excipient (NE), which has better floatation and can be prepared with more simple pharmaceutical techniques for the treatment of diabetes Mellitus. Methods: A gastro-retentive floating matrix tablet (GFT) formulation of MH was prepared using various concentrations of PEO (Polyox WSR-303) and hydroxypropyl methylcellulose K100M (HPMC K100 M) and Floating agent (novel excipient) to achieve desirable TFT, FLT and drug release. The wet granulation method was selected using isopropyl alcohol as a binder for the preparation of tablets. D-optimal non-simplex mixture design was used for the selection of suitable polymer concentrations and floating agents. Release kinetics was used to determine the mechanism of drug release. Results: It was observed that GFT with optimum quantities of PEO, HPMC K100M, and the floating agent showed 100 % of drug release in 24h with FT up to 24h and minimum FLT of less than 2 min. Formulation with an in vitro release profile slower to the marketed sample was prepared. Conclusion: A sustained-release (GFT) of MH tablets using PEO, HPMC K100M, and an effervescent system was successfully prepared. A GFT formulation with an in vitro release profile slower to the marketed sample that releases MH for 24h may suitable for once-daily dosing can be prepared

Quantitatively evaluating greenhouse gas leakage from CO2 enhanced oil recovery fields

Greenhouse gas (mainly CO2 and CH4) leakage from abandoned wells in CO2 enhanced oil recovery sites is a long-standing environmental concern and health hazard. Although multiple CO2 capture, utilization, and storage programs, e.g., CarbonSAFE and Regional Carbon Storage Partnerships, have been developed in the U.S. to reach the net-zero emission target by 2050, one cannot neglect the significant amount of CO2 and CH4 leakage from abandoned wells. This study will investigate the potential of CO2 and oil components leakages from the abandoned wellbore and develop the first-ever quantitative approach to evaluating CO2 and oil component leakage from a CO2 enhanced oil recovery field. Results show that in addition to a large amount of CO2 leakage, a significant amount of light and intermediate oil components leaked through the wellbore. In contrast, a minimal amount of heavy oil component leaked. Oil components’ leakage is mainly through the gas phase rather than the liquid phase. CO2 leakage is positively correlated to reservoir depth, wellbore pressure, and permeability through sensitivity analysis. In contrast, it is negatively related to net-to-gross ratio, residual oil saturation, and mole fraction of CH4. On the other hand, oil component leakages are positively correlated to all uncertain parameters, except the net-to-gross ratio. Lastly, the reduced-order models generated using the machine learning technique have a relatively high fidelity.Cited as: Chen, B., Mehana, M. Z., Pawar, R. J. Quantitatively evaluating greenhouse gas leakage from CO2 enhanced oil recovery fields. Advances in Geo-Energy Research, 2023, 7(1): 20-27. https://doi.org/10.46690/ager.2023.01.0

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Azimuthal asymmetries in DD-meson and jet production at the EIC

We study the azimuthal asymmetries in back-to-back leptoproduction of $D$-meson and jet to probe the gluon TMDs in an unpolarized and transversely polarized electron-proton collision at the kinematics of EIC. We give predictions for unpolarized cross-sections within the TMD factorization framework. In $D$-meson and jet formation, the only leading order contribution comes from the photon gluon fusion process. We give numerical estimates of the upper bound on the azimuthal asymmetries with the saturation of positivity bounds; also, we present the asymmetries using a Gaussian parameterization of TMDs. We obtain sizable asymmetries in the kinematics that will be accessible at EIC.Comment: 19 pages, 13 figures, the version to be published in PR

Clear cell variant of oral squamous cell carcinoma: case report and review

The clear cell variant of Oral Squamous Cell Carcinoma (OSCC) is an uncommon histological variant. Kuo first discovered it in the skin, and Frazier et al. found it in the oral cavity. We know of only nine cases of clear cell variant of OSCC reported in the literature till now. The present case is in a 60-year-old male patient with an ulcer on the left posterolateral border of the tongue. The patient had a history of chewing tobacco for 22 years. Clinical examination showed features of malignant ulcer associated with pain and discomfort. Histopathological examination revealed sheets and islands of atypical epithelial cells with clear cytoplasm, nuclear and cellular pleomorphism, and few keratin pearls in the connective tissue suggesting OSCC. Various special stains were performed to identify clear cells. Periodic Acid Schiff-Diastase (PAS-D) and Mucicarmine stains showed positive and negative reactions in clear cells, respectively. Immunohistochemical (IHC) analysis for cytokeratin (AE1/AE3) showed diffuse positivity in clear cells and other epithelial cells. Based on special stains and IHC markers, we confirmed the diagnosis as a clear cell variant of OSCC. This variant is rare and presents diagnostic challenges. It is said to be aggressive in nature. More such cases should be reported to understand its biological behavior and prognosis

Effect of Chandana Bala Lakshadi Taila Abhyanga with Poshaka Laddu & Nutri Recharge Powder in Bala Shosha (Kuposhana Janya Vyadhi)

Introduction: In Ayurveda Bala Shosha is known as Kuposhan Janya Vyadhi and it is viewed under Malnutritional or PEM disorder. Malnutrition is a common health problem in preschool children of developing countries including in India. As per WHO poor feeding of infant and young children resulting in under nutrition is the single and most important factor for diseases. The malnourished child needs proper Ahara and Aaushadh for normal growth and protecting disease. So, we have made suitable plan to a child.   Aim: To evaluate the effect of Candana Bala Lakshadi Taila Abhyanga, Poshaka Laddu, Nurticharge Powder internally in Bala Shosha (Kuposhana Janya Vyadhi). Material & Method: The clinical study was conducted in 30 Malnourished Children pre and post evaluation without control. The Study setting Department of Koumarbhritya (Bal-Roga), Shubhdeep Ayurved Medical College, Indore M.P. This study is come under the project of Govt. of M.P. in supervision of Indore collector and funded by Govt. of M.P. Result: The effect of Nuticharge powder, Poshak Laddu & Abhyanga on child weight and M.U.A.C is statistically significant (P= 0.01). It showed that the treatment significantly increases the weight and mid under arm circumference of malnourished children. Conclusion: Here in this study a small group was taken for the study which is equated with the PEM & Kuposhana Janya Vyadhi

Charge density studies of energetic material: RDX

Experimental charge density study has been carried out for Cyclotrimethylene-trinitramine (space group Pbca), an explosive material from a low temperature X-ray diffraction experiment. The electron density was modeled using the Hansen-Coppens multipole model and refined to R=0.032 for 6226 unique observed reflections. The electron density, laplacian and electrostatic potential distributions are reported and discussed, especially, the properties of the bond (3,-1) critical points, which are thought to play a key role in the decomposition of the molecule. From the bond topological analysis of all the bonds, it is observed that the N–N bond is the weakest. The dominating nature of the oxygen atoms was clearly well understood from isosurface electrostatic potential of isolated and symmetrically sitting molecules in the crystal

Clear cell variant of oral squamous cell carcinoma: case report and review

The clear cell variant of Oral Squamous Cell Carcinoma (OSCC) is an uncommon histological variant. Kuo first discovered it in the skin, and Frazier et al. found it in the oral cavity. We know of only nine cases of clear cell variant of OSCC reported in the literature till now. The present case is in a 60-year-old male patient with an ulcer on the left posterolateral border of the tongue. The patient had a history of chewing tobacco for 22 years. Clinical examination showed features of malignant ulcer associated with pain and discomfort. Histopathological examination revealed sheets and islands of atypical epithelial cells with clear cytoplasm, nuclear and cellular pleomorphism, and few keratin pearls in the connective tissue suggesting OSCC. Various special stains were performed to identify clear cells. Periodic Acid Schiff-Diastase (PAS-D) and Mucicarmine stains showed positive and negative reactions in clear cells, respectively. Immunohistochemical (IHC) analysis for cytokeratin (AE1/AE3) showed diffuse positivity in clear cells and other epithelial cells. Based on special stains and IHC markers, we confirmed the diagnosis as a clear cell variant of OSCC. This variant is rare and presents diagnostic challenges. It is said to be aggressive in nature. More such cases should be reported to understand its biological behavior and prognosis