1-(2-Azido­acet­yl)-3-methyl-2,6-diphenyl­piperidin-4-one

In the title compound, C20H20N4O2, the piperidine ring adopts a distorted boat conformation. The two phenyl rings form dihedral angles of 82.87 (1) and 84.40 (1)° with respect to the piperidine ring. The crystal packing is stabilized by inter­molecular C—H⋯O and C—H⋯N inter­actions

(E)-Ethyl 2-cyano-3-(1H-pyrrol-2-yl)acrylate

All the non-H atoms of the title compound, C10H10N2O2, are nearly in the same plane with a maximum deviation of 0.093 (1) Å. In the crystal, adjacent mol­ecules are linked by pairs of inter­molecular N—H⋯O hydrogen bonds, generating inversion dimers with R 2 2(14) ring motifs

8-[(Hydrazinyl­idene)meth­yl]-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl­benzene­sulfonate

In the title compound, C18H16N2O5S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.078 (1) Å (r.m.s. deviation = 0.046 Å). The dihedral angle between the coumarin ring system and the toluene ring (r.m.s. deviation = 0.004 Å) is 2.77 (1)°. The crystal packing is stabilized by C—H⋯O and N—H⋯O inter­molecular hydrogen bonds generating C(8), C(9) and C(11) chains and R 2 2(14), R 2 2(23) and R 4 3(13) ring graph sets

(Z)-2-[2-(4-Methyl­benzyl­idene)hydrazin­yl]pyridine

Mol­ecules of the title compound, C13H13N3, are essentially planar (r.m.s. deviation for all non-H atoms = 0.054 Å). The dihedral angle between the two aromatic rings is 6.33 (5)°. In the crystal, pairs of centrosymmetrically related mol­ecules are linked through N—H⋯N hydrogen bonds, forming N—H⋯N dimers with graph-set motif R22(8)

Ethyl 4-(3-bromo­phen­yl)-6-methyl-2-oxo-1,2,3,4-tetra­hydro­pyrimidine-5-carboxyl­ate

In the title compound, C14H15BrN2O3, the dihydro­pyrimidin­one ring adopts a boat conformation. In the crystal, adjacent mol­ecules are linked through N—H⋯O hydrogen bonds forming an R22(8) ring motif and generating a zigzag chain extending in [010]

(E)-Ethyl 2-cyano-3-(furan-2-yl)acrylate

There are two independent mol­ecules in the asymmetric unit of the title compound, C10H9NO3, in both of which, all non-H atoms except for the methyl C atom lie nearly in the same plane [maximum deviations = 0.094 (3) and 0.043 (2) Å]. In the crystal, each independent mol­ecules is linked by pairs of C—H⋯O inter­actions, generating inversion dimers with R 2 2(10) ring motifs

1-(3,5-Dichloro­phen­yl)-1H-1,2,3,4-tetra­zole

In the title compound, C7H4Cl2N4, the dihedral angle between the tetra­zole and benzene rings is 17.2 (2)°. In the crystal, C—H⋯N inter­actions link the mol­ecules into a flattened helical chain along the b axis

Pd(OAc) 2 catalyzed synthesis of 2-aryl- and 2-heteroaryl- benzoxazoles and benzothiazoles in imidazolium ionic liquids (ILs) without additives and with recycling/reuse of the IL

A facile, high yielding, method for the synthesis of a library of 2-aryl- and 2-heteroaryl-benzoxazoles and benzothiazoles from readily available Schiff bases is reported employing catalytic amounts of Pd(OAc) 2 in imidazolium ionic liquids (bmim)BF 4 and (bmim)PF 6 without ligands and/or additives. Simple product isolation and recycling/re-use of the IL are additional advantages of this method. © 2012 Elsevier Ltd. All rights reserved

Triflic Anhydride: A Mild Reagent for Highly Efficient Synthesis of 1,2-Benzisoxazoles, Isoxazolo, and Isothiazolo Quinolines Without Additive or Base

<div><p></p><p>The synthetic utility of trifluoromethanesulphonic anhydride (triflic anhydride, TA) without additive or base for the high-yielding synthesis of a wide variety of 1,2-benzisoxazoles from 2-hydroxyaryl aldoximes and ketoximes under mild conditions has been carried out for the first time. As a continuation of our study, syntheses of isoxazolo and isothiazolo quinolones have also been demonstrated using triflic anhydride under similar conditions. This method is simple and has benefits from the easy way to isolate the products in excellent yields.</p> <p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Synthetic Communications</i>® for the following free supplemental resource(s): Full experimental and spectral details.]</p> </div

Highly Efficient Synthesis of 1,3-Dioxanes via Prins Reaction in Brønsted-Acidic Imidazolium Ionic Liquid

<div><p></p><p>The high-yielding synthesis of a wide variety of 1,3-dioxanes via the Prins reaction under mild conditions has been demonstrated using Brønsted-acidic imidazolium ionic liquid [bmim(SO₃H)][OTf] or bmimOTf. The use of ionic liquid makes this synthesis simple, convenient, cost-effective, and environmentally friendly. Furthermore, bmimOTf was conveniently separated from the products and can be easily recycled for the Prins reaction with excellent yields. This method works well with a variety of aliphatic aldehydes including formaldehyde, acetaldehyde, propionaldehyde, and cyclohexanecarboxaldehyde.</p> <p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Synthetic Communications®</i> for the following free supplemental resource(s): Full experimental and spectral details.]</p> </div