6 research outputs found

    The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

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    Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer
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