Polymorphous low grade adenocarcinoma-an unusual presentation

Polymorphous low-grade adenocarcinoma (PLGA) is a neoplasm that occurs frequently in the mucosa of the soft and hard palates, in the buccal mucosa and in the upper lip and is very rare within the nasopharynx. We present a case of PLGA, which presented as a nasal polyp

Rare Coinfection of Scrub Typhus and Malaria in Immunocompetent Person

Scrub Typhus, or tsutsugamushi disease is a febrile illness caused by bacteria of the family Rickettsiaceae and named Orientia tsutsugamushi. Recently it has been found to endemic in Subhimalayan region of India.Malaria is highly endemic in rest of India but its prevalence is low in Subhimalayan region because of the altitude. We report a rare case of a patient having coinfection with scrub typhus and malaria

Primary Amoebic (Naegleria fowleri) Meningoencephalitis Presenting as Status Epilepticus

Primary amebic meningoencephalitis (PAM) is a rare entity. Usual presenting features are fever, headache and seizures with meningeal signs and this disease carries high mortality rate. We present a case report of PAM presenting as status epilepticus

A Typology of Antipassives, With Special Reference to Mayan.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia.

Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD). This model incorporates two characteristic features of human irritable bowel syndrome (IBS), VH and a prominent role of stress in the onset and exacerbation of IBS symptoms. Little is known regarding central mechanisms underlying the stress-induced VH. Here, we applied an autoradiographic perfusion method to map regional and network-level neural correlates of VH. Adult male rats were exposed to WAS or sham treatment for 1 hour/day for 10 days. The visceromotor response was measured before and after the treatment. Cerebral blood flow (CBF) mapping was performed by intravenous injection of radiotracer ([(14)C]-iodoantipyrine) while the rat was receiving a 60-mmHg CRD or no distension. Regional CBF-related tissue radioactivity was quantified in autoradiographic images of brain slices and analyzed in 3-dimensionally reconstructed brains with statistical parametric mapping. Compared to sham rats, stressed rats showed VH in association with greater CRD-evoked activation in the insular cortex, amygdala, and hypothalamus, but reduced activation in the prelimbic area (PrL) of prefrontal cortex. We constrained results of seed correlation analysis by known structural connectivity of the PrL to generate structurally linked functional connectivity (SLFC) of the PrL. Dramatic differences in the SLFC of PrL were noted between stressed and sham rats under distension. In particular, sham rats showed negative correlation between the PrL and amygdala, which was absent in stressed rats. The altered pattern of functional brain activation is in general agreement with that observed in IBS patients in human brain imaging studies, providing further support for the face and construct validity of the WAS model for IBS. The absence of prefrontal cortex-amygdala anticorrelation in stressed rats is consistent with the notion that impaired corticolimbic modulation acts as a central mechanism underlying stress-induced VH

Analysis of thermal desorption of hydrogen in metallic alloys

The degree of embrittlement of metallic alloys is sensitive to the concentration of absorbed hydrogen, with hydrogen traps (particularly at grain boundaries) playing an important role. Thermal desorption spectrometry (TDS) is widely used to measure the detrapping and diffusion behaviour of hydrogen in metallic alloys. However, it is problematic to obtain a consistent interpretation of TDS data from the literature, due to the large number of material parameters that influence the measurement, and this results in a wide range of quoted values for trapping parameters such as the number of trap types, trap binding energies and trap densities. In this paper, the governing partial differential equation for hydrogen diffusion with sink and source terms for a single trap is formulated in non-dimensional form, assuming local equilibrium between the hydrogen atoms at the lattice sites and the trap sites. An asymptotic analysis reveals two distinct regimes of diffusion behaviour in TDS tests. Kissinger-type behaviour is expected in a TDS test for low heating rates on an alloy with a low lattice activation energy. Contour maps of maximum hydrogen flux and the corresponding temperature are plotted using axes of trap density and trap binding energy by making use of the full numerical solution (and asymptotic solutions). These maps serve as a useful tool for an accurate and simple determination of the trap binding energy as well as the trap density.ERC H2020 GA66976