Synthesis, characterization, molecular docking and antibacterial activities of Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)- 3-oxopropanamideZinc (II) complex

50-58The title Zn (II) complex was synthesized by reacting the compound Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)-3-oxo propanamide with Zn (II) chloride dihydrate in alkaline dimethylsulphoxide and ethanol solution under reflexing condition for 8 h. The resultant compound was filtered and recrystallized from ethanol. The hydrazone Schiff base ligand and its Zn (II) complex were characterized by using UV-Vis spectroscopy and XRD, TEM and SEM analysis. The antibacterial activities of ligand and its Zn complex were examined using disc diffusion method. The spectra results showed that the hydrazone ligand undergoes keto-enoltautomerism forming a bidentated ligand (N,N) towards Zn+2 (II) ion. It is very interesting that on sides of the two hydrazone ligands which coordinate to the Zn+2 ions, an additional two thiosemicarbazine moiety were also coordinated with Zn+2 ions in the crystalline powder, resulting in a hexa coordinated octahedral Zn (II) complex. Both hydrazone Schiff base ligand and its Zn (II) complex were found to exhibit good antibacterial activity even when the concentrations were high. Molecular docking analysis also deciphered that Zinc complex and carbohydrazone ligand both were found to be fitted into the active sites of molecular targets and Zn complex showed better binding affinities towards macromolecules compared to ligand

Molecular docking and Antibacterial activities of Cobalt (II) complexes derived from precursors of Hydrazones

The Schiff base ligands in their deprotonated forms have been utilized to synthesize thermodynamically and kinetically stabilized Cobalt(II) complexes. In the complexes, cobalt ion present is in distorted octahedral arrangement and is coordinated by four tridentate ligands in complexes. The synthesized Schiff base ligands coordinate with Cobalt (II) ion through four azomethine nitrogen atoms and two sulfur atoms developing a 6- membered chelate ring. Synthesized Cobalt(II) complexes via hexadentate ligands have been characterized thoroughly through various spectroscopic techniques like FT-IR, UV-Vis, 1HNMR, TGA, TEM, SEM, Particle size, Elemental analysis (C, H, N, Co, S) and conductivity measurements. All Cobalt(II) complexes have been evaluated for in vitro antimicrobial activity against isolated bacterial strains of E. coli (MTCC-1687), E. faecalis (MTCC-439), S. aureus (MTCC-737) and MR S. aureus (Indigenous). All Cobalt complexes show mild to moderate antibacterial activity. The MIC ranged from 50 µg/ mL to 3.125 µg/ mL. All Cobalt(II) complexes displayed in-vitro antibacterial activity against both gram-positive and gram-negative bacterial strains. It may be proved that the antibacterial activity of the complexes is related to the cell wall structure of the tested bacteria. In-vitro toxicity tests explained the Cobalt complexes were less cytotoxic than the Vancomycin drug on A431 cancer cell lines and the results explain that synthesized Cobalt complexes can act as potent antimicrobial agents and can be considered as a good drug candidate for medicinal chemistry researchers

Molecular docking and Antibacterial activities of Cobalt (II) complexes derived from precursors of Hydrazones

640-652The Schiff base ligands in their deprotonated forms have been utilized to synthesize thermodynamically and kinetically stabilized Cobalt(II) complexes. In the complexes, cobalt ion present is in distorted octahedral arrangement and is coordinated by four tridentate ligands in complexes. The synthesized Schiff base ligands coordinate with Cobalt (II) ion through four azomethine nitrogen atoms and two sulfur atoms developing a 6- membered chelate ring. Synthesized Cobalt(II) complexes via hexadentate ligands have been characterized thoroughly through various spectroscopic techniques like FT-IR, UV-Vis, 1HNMR, TGA, TEM, SEM, Particle size, Elemental analysis (C, H, N, Co, S) and conductivity measurements. All Cobalt(II) complexes have been evaluated for in vitro antimicrobial activity against isolated bacterial strains of E. coli (MTCC-1687), E. faecalis (MTCC-439), S. aureus (MTCC-737) and MR S. aureus (Indigenous). All Cobalt complexes show mild to moderate antibacterial activity. The MIC ranged from 50 μg/ mL to 3.125 μg/ mL. All Cobalt(II) complexes displayed in-vitro antibacterial activity against both gram-positive and gram-negative bacterial strains. It may be proved that the antibacterial activity of the complexes is related to the cell wall structure of the tested bacteria. In-vitro toxicity tests explained the Cobalt complexes were less cytotoxic than the Vancomycin drug on A431 cancer cell lines and the results explain that synthesized Cobalt complexes can act as potent antimicrobial agents and can be considered as a good drug candidate for medicinal chemistry researchers

Synthesis, characterization, molecular docking and antibacterial activities of Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)-3-oxopropanamideZinc (II) complex

The title Zn (II) complex was synthesized by reacting the compound Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)-3-oxo propanamide with Zn (II) chloride dihydrate in alkaline dimethylsulphoxide and ethanol solution under reflexing condition for 8 h. The resultant compound was filtered and recrystallized from ethanol. The hydrazone Schiff base ligand and its Zn (II) complex were characterized by using UV-Vis spectroscopy and XRD, TEM and SEM analysis. The antibacterial activities of ligand and its Zn complex were examined using disc diffusion method. The spectra results showed that the hydrazone ligand undergoes keto-enoltautomerism forming a bidentated ligand (N,N) towards Zn+2 (II) ion. It is very interesting that on sides of the two hydrazone ligands which coordinate to the Zn+2 ions, an additional two thiosemicarbazine moiety were also coordinated with Zn+2 ions in the crystalline powder, resulting in a hexa coordinated octahedral Zn (II) complex. Both hydrazone Schiff base ligand and its Zn (II) complex were found to exhibit good antibacterial activity even when the concentrations were high. Molecular docking analysis also deciphered that Zinc complex and carbohydrazone ligand both were found to be fitted into the active sites of molecular targets and Zn complex showed better binding affinities towards macromolecules compared to ligand

Evaluation of the mechanical properties of conventional glass ionomer cement after the addition of casein phosphopeptide amorphous calcium phosphate: An in vitro study

Background: Casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) products have gained much importance in restorative dentistry and minimally invasive dentistry. Addition of CPP into glass ionomer cement (GIC) has been shown to interact with fluoride ions to produce an additive anticariogenic effect through the formation of stabilized amorphous calcium fluoride phosphate phase. Aim: The aim of this study was to determine the additive effect of CPP-ACP on the mechanical properties of conventional GIC. Materials and Methods: The control GIC was prepared with self-curing GIC. The GIC containing CPP-ACP was prepared from the same batch, with 1.56% w/w CPP-ACP incorporated. Compressive strength and microtensile bond strength tests were done. Energy dispersive X-ray (EDX) analysis was used to determine the composition of various structural phases. Results: Incorporation of 1.56% w/w CPP-ACP into the GIC resulted in an increase in compressive strength and microtensile bond strength. The representative EDX spectra taken showed enhanced release of calcium, phosphate, and fluoride ions