A new species in the major malaria vector complex sheds light on reticulated species evolution

Complexes of closely related species provide key insights into the rapid and independent evolution of adaptive traits. Here, we described and studied Anopheles fontenillei sp.n., a new species in the Anopheles gambiae complex that we recently discovered in the forested areas of Gabon, Central Africa. Our analysis placed the new taxon in the phylogenetic tree of the An. gambiae complex, revealing important introgression events with other members of the complex. Particularly, we detected recent introgression, with Anopheles gambiae and Anopheles coluzzii, of genes directly involved in vectorial capacity. Moreover, genome analysis of the new species allowed us to clarify the evolutionary history of the 3La inversion. Overall, An. fontenillei sp.n. analysis improved our understanding of the relationship between species within the An. gambiae complex, and provided insight into the evolution of vectorial capacity traits that are relevant for the successful control of malaria in Africa

Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial

BACKGROUND: The effects of ezetimibe on cholesterol metabolism in HIV-infected patients receiving boosted protease inhibitors have not been thoroughly assessed. The aim of this study was to assess cholesterol homeostasis in patients with PI associated dyslipidemia and its relationship with the response to treatment with the cholesterol-absorption inhibitor ezetimibe. METHODS: Fifteen patients with ritonavir-boosted PI-containig therapy and LDL-cholesterol > 3.36 mmol/L (>130 mg/dL) were assessed at baseline and after an 8-week course of ezetimibe 10 mg/d. Serum non-cholesterol sterols were measured at each visit as markers of cholesterol synthesis and absorption. Total-, LDL-, and HDL-cholesterol triglycerides, apolipoproteins A1 and B, high sensitivity C-reactive protein, CD4 cells and HIV-1 RNA were also measured. RESULTS: Ezetimibe treatment was well tolerated in all patients and resulted in significant reductions in total cholesterol (-11.4%, p = .002), LDL-cholesterol (-20.4%, p = .003), non-HDL-cholesterol (-13.4%, p = .002) and apolipoprotein B (-9.1%, p = .021). Treatment with ezetimibe was associated with decreased cholesterol absorption markers (campesterol-to-cholesterol ratio -43.0%, p = .001; sitosterol-to-cholesterol ratio -41.9%, p = .001) and increased synthesis markers (lathosterol-to-cholesterol ratio 53.2%, p = .005). Baseline absorption or synthesis markers were unrelated to the response to treatment. CD4 cell count and plasma HIV-1 RNA remained unchanged. CONCLUSIONS: The level of cholesterol absorption or synthesis does not appear to be a major determinant of the responsiveness to ezetimibe in patients on ritonavir-boosted PI-containing therapy

Urban informality and confinement: toward a relational framework

In the 21st century, a growing number of people live ‘informal’ lives within fissures between legality and informality. Concomitantly, power relations are increasingly expressed through devices of confinement. While urban informality and confinement are on the rise often occurring simultaneously, scholars have so far studied them separately. By contrast, this article proposes a new framework for analysing urban informality and confinement relationally. It generates new insights into the role of informality in the (re)production of confinement and, vice versa, the role of confinement in shaping informal practices. While these insights are valuable for urban studies in general, the article charts new lines of research on urban marginality. It also discusses how the six articles included in this special issue signal the heuristic potential of this relational framework by empirically examining distinct urban configurations of ‘confined informalities’ and ‘informal confinements’ across the Global North and the Global South

New features of the phase transition to superconducting state in thin films

The Halperin-Lubensky-Ma (HLM) effect of a fluctuation-induced change of the order of phase transition in thin films of type I superconductors with relatively small Ginzburg-Landau number $\kappa$ is considered. Numerical data for the free energy, the order parameter jump, the latent heat, and the specific heat of W, Al and In are presented to reveal the influence of film thickness and material parameters on the properties of the phase transition. We demonstrate for the first time that in contrast to the usual notion the HLM effect occurs in the most distinct way in superconducting films with high critical magnetic field $H_{c0}$ rather than in materials with small $\kappa$. The possibility for an experimental observation of the fluctuation change of the order of superconducting phase transition in superconducting films is discussed.Comment: 11 pages, MikTexTeX, 3 fig, 2 Tables, corrected some typos, Submitted J.Phys:Cond Ma

Acció de l'hormona alliberadora de la Tirotropina (TRH) damunt mecanismes andrenèrgics

Des de fa uns quants anys hom sospitava l'existencia de substàncies d'origen hipotalàmic amb acció reguladora de les secrecions anterohipo­fisàries; convencionalment eren denominades «factor d'alliberació» (re­leasing factors). Generalment hom substituïa el terme «factor» pel d'«hormona» tan aviat com aconseguia de determinar-ne l'estructura química. Aquest és el cas de l'hormona alliberadora de la tirotropina hipofisària (TRH: thyrotropin-releasing hormone), coneguda abans com a factor alliberador de la tirotropina (TRF: thyrorropin-releasing factor)