Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis.

Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can be induced by repeated neuronal firing and/or under conditions of sustained membrane depolarisation, as is expected for hyperexcitable neurones in pathological conditions such as epilepsy and neuropathy, and probably osteoarthritis (OA). In this study, therefore, we examined the antinociceptive effect of LCM on spinal neuronal and behavioural measures of pain, in vivo, in a rat OA model

Comparison of performance and emission characteristics between ceramic and metallic catalytic converter

Catalytic converters have been widely used on vehicles and have already been proved for many years to be the most effective technical solution to reduce exhaust emissions from gasoline engines where ceramic and metallic catalytic converters are the most common types of catalytic converter used. This study focuses to examine the performance of ceramic and metallic catalytic converters through simulation and experimental in terms of flow distribution and pollutant gases conversion. ANSYS Fluent 16.2 has been used for the simulation process and Mitsubishi 4G93 1800cc gasoline engine with difference speed and 25% constant load were used for the emission measurement using Kane Auto 5-1 series exhaust gas analyser. Simulation process has been conducted to measure pressure, velocity and temperature distribution through the ceramic and metallic catalytic converter and for the experimental process, the performances and pollutant gases conversion were recorded to compare both type of catalytic converters. Based on the simulation results, ceramic honeycomb catalytic converter shows higher pressure distribution 181.1 Pa on the inlet region compares to metallic sinusoidal. On the other hands, metallic sinusoidal catalytic converter has better velocity distribution of 14.3 ms- 1and temperature distribution of 1100 Kat the inlet region. Through the experimental results, metallic sinusoidal catalytic converter performs a better reduction of CO compares to ceramic honeycomb catalytic convetier while ceramic honeycomb performs better reduction than metallic sinusoidal catalytic converter for HC and NOx conversion. It can be concluded that metallic corrugated catalytic converter has performs better flow distribution through the substrates while ceramic converters reduce a higher percentage of CO and NOx pollutant gases

Design of Power-Splitter With Selectable Splitting-Ratio Using Angled and Cascaded MMI-Coupler

A concept of power splitter with selectable splitting-ratios is proposed based on two multimode interference (MMI) sections connected by a phase-shifting region, in which phase-matching conditions can be fulfilled by using a simple angled section or alternatively using matched phase-shifters. The design example of an asymmetrical splitter (10 : 90) is optimized by using the transfer matrix method and three-dimensional full-vectorial beam propagation method. The numerical results reveal that a simple 1.2° angled section can yield a 10 : 90 splitter with an insertion loss of 0.74 dB and a total length of 192 μm. It is also shown that, for the cascaded MMI couplers based splitter, a more compact length of 58 μm with a lower insertion loss of 0.41 dB can be achieved. The fabrication tolerances are also investigated for the proposed asymmetrical power splitter

SUBDIVISION SPECIFIC AMENITIES AND RESIDENTIAL PROPERTY VALUES

A hedonic property value model, derived from a dynamic game theoretic framework, is estimated using data obtained for 211 subdivisions including 4628 building lots in five Maryland counties. Linear Box-Cox estimation results show that variables measuring subdivision specific amenities significantly affect residential property values, and omission of such variables produces biased coefficient estimates.Land Economics/Use,

Computing Covers Using Prefix Tables

An \emph{indeterminate string} $x = x[1..n]$ on an alphabet $\Sigma$ is a sequence of nonempty subsets of $\Sigma$; $x$ is said to be \emph{regular} if every subset is of size one. A proper substring $u$ of regular $x$ is said to be a \emph{cover} of $x$ iff for every $i \in 1..n$, an occurrence of $u$ in $x$ includes $x[i]$. The \emph{cover array} $\gamma = \gamma[1..n]$ of $x$ is an integer array such that $\gamma[i]$ is the longest cover of $x[1..i]$. Fifteen years ago a complex, though nevertheless linear-time, algorithm was proposed to compute the cover array of regular $x$ based on prior computation of the border array of $x$. In this paper we first describe a linear-time algorithm to compute the cover array of regular string $x$ based on the prefix table of $x$. We then extend this result to indeterminate strings.Comment: 14 pages, 1 figur

Inferring an Indeterminate String from a Prefix Graph

An \itbf{indeterminate string} (or, more simply, just a \itbf{string}) \s{x} = \s{x}[1..n] on an alphabet $\Sigma$ is a sequence of nonempty subsets of $\Sigma$. We say that \s{x}[i_1] and \s{x}[i_2] \itbf{match} (written \s{x}[i_1] \match \s{x}[i_2]) if and only if \s{x}[i_1] \cap \s{x}[i_2] \ne \emptyset. A \itbf{feasible array} is an array \s{y} = \s{y}[1..n] of integers such that \s{y}[1] = n and for every $i \in 2..n$, \s{y}[i] \in 0..n\- i\+ 1. A \itbf{prefix table} of a string \s{x} is an array \s{\pi} = \s{\pi}[1..n] of integers such that, for every $i \in 1..n$, \s{\pi}[i] = j if and only if \s{x}[i..i\+ j\- 1] is the longest substring at position $i$ of \s{x} that matches a prefix of \s{x}. It is known from \cite{CRSW13} that every feasible array is a prefix table of some indetermintate string. A \itbf{prefix graph} \mathcal{P} = \mathcal{P}_{\s{y}} is a labelled simple graph whose structure is determined by a feasible array \s{y}. In this paper we show, given a feasible array \s{y}, how to use \mathcal{P}_{\s{y}} to construct a lexicographically least indeterminate string on a minimum alphabet whose prefix table \s{\pi} = \s{y}.Comment: 13 pages, 1 figur

String Comparison in VV-Order: New Lexicographic Properties & On-line Applications

$V$-order is a global order on strings related to Unique Maximal Factorization Families (UMFFs), which are themselves generalizations of Lyndon words. $V$-order has recently been proposed as an alternative to lexicographical order in the computation of suffix arrays and in the suffix-sorting induced by the Burrows-Wheeler transform. Efficient $V$-ordering of strings thus becomes a matter of considerable interest. In this paper we present new and surprising results on $V$-order in strings, then go on to explore the algorithmic consequences

Subdivision Specific Amenities and Residential Property Values

A hedonic property value model, derived from a dynamic game theoretic framework, is estimated using data obtained for 211 subdivisions including 4628 building lots in five Maryland counties. Linear Box-Cox estimation results show that variables measuring subdivision specific amenities significantly affect residential property values, and omission of such variables produces biased coefficient estimates.Land Economics/Use, Public Economics,