UNIVERSITY STUDENTS’ KNOWLEDGE AND MISCONCEPTIONS ABOUT CELL STRUCTURE AND FUNCTIONS

This study aims to assess the level of understanding of biology students and to identify their misconceptions about cell concepts. Participants of the study (n=160) were students enrolled in biology undergraduate level. Data analysis showed that the students had cell-related misconceptions. The misconceptions were found in four basic competencies of the cell concepts. The most common misconceptions (55.68%) among students are those related to the relationship between the structure and function of the nucleus and endoplasmic reticulum. We denote that most of the students have assimilated the concepts related to the chemical constituents of the cell. There are several potential factors that cause the occurrence of misconceptions among the participants in this study, including low retention of knowledge obtained in previous school levels, lack of learning resources, incomprehensible terms, and low interest of biology students in cell concepts.  Article visualizations

Assessment of Knowledge and Learning Difficulties in Metamorphism Among Future Teachers

The present research focuses on evaluating the knowledge and learning difficulties in metamorphism among future teachers. To address our issue, we selected a sample from students at the Ecole Normale Supérieure de Marrakech and employed a questionnaire as our investigative tool. The obtained results indicate that students face learning problems in metamorphism. These difficulties arise in understanding certain key concepts of metamorphism, such as metamorphic facies and migmatite. We also observed that students struggle to establish connections between metamorphism and other geological phenomena. These learning difficulties can be attributed to language barriers, didactic transposition, the persistence of certain misconceptions, and the discipline itself, such as problems in comprehending geological space and time. This research could aid university professors in understanding these difficulties and in designing teaching scenarios that would help students better grasp geological concepts

Views of Moroccan University Teachers on Plant Taxonomy and Its Teaching and Learning Challenges

Plant taxonomy includes the identification, description, and classification of plants at the level of species or other taxa. This study aims to analyze the views of university teachers on plant taxonomy and its teaching, the causes of the shortage of plant taxonomists, and the challenges encountered by students in learning plant taxonomy. University teachers in Morocco (n = 24) responded to a survey consisting of fixed and open-ended questions. The data was analyzed by inductive and deductive content analysis. The results showed that all university teachers considered a taxonomist as a scientist and plant taxonomy as a dynamic and highly scientific, and descriptive discipline. They stated that the taxonomist community is in crisis because of the shortage of plant taxonomists and the decrease in the quality of training provided at the university. The biggest challenges in learning plant taxonomy were the prevalence of traditional teacher-centered methods, the inadequacy of time and didactic resources spent on teaching, and the Latin nomenclature. The difficulties associated with the concept of evolution and the diversity of classifications were also mentioned. The angiosperm group was the most difficult for students to understand. Furthermore, this research shows that the financial, human, institutional, pedagogical, and didactic resources for the teaching of plant taxonomy are insufficient and do not allow for the use of teaching methods supporting learning. How to plant taxonomy is taught is important, and when it is considered difficult, it can lead to a reluctance to study plant species and be one of the reasons for the decline in plant taxonomists in Morocco. Consequently, this issue can negatively affect the preservation and conservation of local flora

The immunogenic profile and immunomodulatory function of mesenchymal stromal / stem cells in the presence of Ptychotis verticillata

Mesenchymal stromal/stem cells (MSCs) are considered to be a promising immunotherapeutic tool due to their easy accessibility, culture expansion possibilities, safety profile, and immunomodulatory properties. Although several studies have demonstrated the therapeutic effects of MSCs, their efficacy needs to be improved while also preserving their safety. It has been suggested that cell homeostasis may be particularly sensitive to plant extracts. The impact of natural compounds on immunity is thus a fascinating and growing field. Ptychotis verticillata and its bioactive molecules, carvacrol and thymol, are potential candidates for improving MSC therapeutic effects. They can be used as immunotherapeutic agents to regulate MSC functions and behavior during immunomodulation. Depending on their concentrations and incubation time, these compounds strengthened the immunomodulatory functions of MSCs while maintaining their immune-evasive profile. Incubating MSCs with carvacrol and thymol does not alter their hypoimmunogenicity, as no induction of the allogeneic immune response was observed. MSCs also showed enhanced abilities to reduce the proliferation of activated T cells. Thus, MSCs are immunologically responsive to bioactive molecules derived from PV. The bioactivity may depend on the whole phyto-complex of the oil. These findings may contribute to the development of safe and efficient immunotherapeutic MSCs by using medicinal plant-derived active molecules

The immunogenic profile and immunomodulatory function of mesenchymal stromal / stem cells in the presence of Ptychotis verticillata

Mesenchymal stromal/stem cells (MSCs) are considered to be a promising immunotherapeutic tool due to their easy accessibility, culture expansion possibilities, safety profile, and immunomodulatory properties. Although several studies have demonstrated the therapeutic effects of MSCs, their efficacy needs to be improved while also preserving their safety. It has been suggested that cell homeostasis may be particularly sensitive to plant extracts. The impact of natural compounds on immunity is thus a fascinating and growing field. Ptychotis verticillata and its bioactive molecules, carvacrol and thymol, are potential candidates for improving MSC therapeutic effects. They can be used as immunotherapeutic agents to regulate MSC functions and behavior during immunomodulation. Depending on their concentrations and incubation time, these compounds strengthened the immunomodulatory functions of MSCs while maintaining their immune-evasive profile. Incubating MSCs with carvacrol and thymol does not alter their hypoimmunogenicity, as no induction of the allogeneic immune response was observed. MSCs also showed enhanced abilities to reduce the proliferation of activated T cells. Thus, MSCs are immunologically responsive to bioactive molecules derived from PV. The bioactivity may depend on the whole phyto-complex of the oil. These findings may contribute to the development of safe and efficient immunotherapeutic MSCs by using medicinal plant-derived active molecules.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Analysis of drawings on representations of COVID-19 among senior high school students:case of the Dakhla-Oued Eddahab region, Morocco

Abstract Since the coronavirus COVID-19 was identified as an international public health emergency in 2020, many studies on the perceptions of students in higher education have been published concerning it. Although young students’ perceptions also influence decision making and actions, their perceptions of COVID-19 have, so far, been little studied. Therefore, to increase knowledge about their understanding of COVID-19, a cross-sectional and descriptive study was conducted as a drawing survey in two schools in the Dakhla-Oued Eddahab region, Morocco. The participants were 94 high school students (aged 14–19). The drawings were analyzed by inductive and deductive content analysis. The findings show that the majority of the students knew the archetypal representation of COVID-19. They had a good grasp of the COVID-19, how it spreads, and how to stop it from spreading. Some students were aware of the potential dangers associated with COVID-19. Admittedly, misrepresentations related to fear and unfamiliarity with COVID-19 lead to mental health issues that undermine the key factors in students’ academic success. Younger children’s representations were dominated by magical thinking that reduces COVID-19 to preventive measures. Overall, the results made it possible to deduce that COVID-19 is strongly associated with terms that are both characteristic and socially valued (disease, prevention, barrier measures, etc.) and, conversely, with rather negative terms (fear of dying, anxiety, sadness, helplessness, etc.). The identification of these representations is very useful because they make it possible to apprehend and understand the attitudes and behaviors of these students, which, therefore, implies the need to define the appropriate teaching methods to try to align these behaviors with the behaviors desired

Views of Moroccan university teachers on plant taxonomy and its teaching and learning challenges

Abstract Plant taxonomy includes the identification, description, and classification of plants at the level of species or other taxa. This study aims to analyze the views of university teachers on plant taxonomy and its teaching, the causes of the shortage of plant taxonomists, and the challenges encountered by students in learning plant taxonomy. University teachers in Morocco (n = 24) responded to a survey consisting of fixed and open-ended questions. The data was analyzed by inductive and deductive content analysis. The results showed that all university teachers considered a taxonomist as a scientist and plant taxonomy as a dynamic and highly scientific, and descriptive discipline. They stated that the taxonomist community is in crisis because of the shortage of plant taxonomists and the decrease in the quality of training provided at the university. The biggest challenges in learning plant taxonomy were the prevalence of traditional teacher-centered methods, the inadequacy of time and didactic resources spent on teaching, and the Latin nomenclature. The difficulties associated with the concept of evolution and the diversity of classifications were also mentioned. The angiosperm group was the most difficult for students to understand. Furthermore, this research shows that the financial, human, institutional, pedagogical, and didactic resources for the teaching of plant taxonomy are insufficient and do not allow for the use of teaching methods supporting learning. How to plant taxonomy is taught is important, and when it is considered difficult, it can lead to a reluctance to study plant species and be one of the reasons for the decline in plant taxonomists in Morocco. Consequently, this issue can negatively affect the preservation and conservation of local flora

Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries

Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially